Preventive Therapy of Postoperative Intra-abdominal Infection Based on Serum Lactate Changes

Launched by PEKING UNION MEDICAL COLLEGE HOSPITAL · Sep 21, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how changes in a substance called serum lactate, measured after surgery, can help predict and prevent infections that may occur after a type of surgery called pancreatic resection. Intra-abdominal infections are serious complications that can arise after this surgery, and the researchers want to find out if giving antibiotics during the surgery can lower the chances of these infections happening. They are looking for participants who have undergone certain types of pancreatic surgeries and who have specific lactate levels after surgery.

To be eligible for this study, patients must be between the ages of 65 and 74, have had a pancreatic resection, and be recovering in an intensive care unit with proper treatment. Participants will need to provide consent to be part of the study and share their medical information. If you join this trial, you can expect careful monitoring of your lactate levels and guidance from the medical team to help reduce the risk of infection after your surgery. Your involvement could contribute to important findings that may improve care for future patients undergoing similar surgeries.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. treatment by pancreatic resection, including pancreaticoduodenectomy, pancreatosplenectomy, total pancreatectomy, and other variant operations;
• • 2. revival in the intensive care unit (ICU) with standard serum lactate elution treatments after surgery instead of the operation room or general ward;
• • 3. availability of complete preoperative, intraoperative, and postoperative data;
• • 4. the peak serum lactate level in 24 hours after surgery \>3.250 mmol/L.
• Exclusion Criteria:
• • 1. a history of surgical treatment of any upper abdominal lesions before the current hospital admission;
• • 2. the minimum mean arterial pressure \<65 mmHg during the operation;
• • 3. without written informed consents for the perioperative situation and related studies.