Bearberry in the Treatment of Cystitis

Launched by UNIVERSITY OF PECS · Sep 21, 2021

Keywords

ClinConnect Summary

This clinical trial is studying the effectiveness of bearberry, a medicinal plant, in treating uncomplicated cystitis, which is an infection of the urinary bladder. Women often experience symptoms like painful urination, a strong need to urinate, and frequent trips to the bathroom when they have this condition. While antibiotics like fosfomycin are commonly used to treat cystitis, not everyone sees a doctor for their symptoms. This study aims to see if bearberry can help ease symptoms just as well as fosfomycin.

To participate in the trial, you must be a premenopausal woman diagnosed with uncomplicated cystitis showing specific symptoms. Participants will be randomly assigned to one of two groups: one group will receive fosfomycin, while the other will receive bearberry tablets, both over a week. Throughout the study, participants will complete questionnaires about their symptoms and provide urine samples to check for bacteria. This trial will help determine whether bearberry is a safe and effective alternative for treating uncomplicated cystitis.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • premenopausal adult women
• • diagnosis of acute uncomplicated cystitis (with the symptoms of dysuria, increased frequency, and urgency of urination and lower abdominal pain (suprapubic pain), that is presumed to be confined to the bladder; with no signs or symptoms that suggest an upper tract or systemic infection)
• • a sum-score of of ≥6 for the typical uncomplicated urinary tract infections symptoms (frequency, urgency, painful urination, incomplete emptying, suprapubic pain, and visible hematuria) reported on the Acute Cystitis Symptom Score (ACSS) typical domain and pyuria (10 white blood cells/mm3 in a mid-stream specimen) at day 0
• Exclusion Criteria:
• • any renal disease
• • upper urinary tract infection
• • malformations of the urinary tract
• • congenital disorders of the urinary tract
• • catheter use
• • pregnancy
• • breastfeeding
• • self-medication with bearberry or antibiotic use in the last 3 months
• • 5 or more bearberry treatments in the previous year
• • concomitant use of other antibiotics and NSAIDs
• • contraindication for study drugs
• • active malignancy
• • immunodeficiency, including immunosuppressive treatment.