UK Imaging Diabetes Study Seeing Diabetes Clearly

Launched by PERSPECTUM · Sep 24, 2021

Keywords

ClinConnect Summary

UK Imaging Diabetes Study Seeing Diabetes Clearly (UKIDS) is a long-term, observational study in adults with type 2 diabetes who have not had cardiovascular disease yet. Researchers will use a special MRI scan to look at the liver and other organs to see if certain MRI measurements can predict future health problems. About 1,000 adults across the UK will join and be followed for up to five years. To participate, people must be 18 or older, have type 2 diabetes, and have no cardiovascular event in the past year, and they must be willing to consent. Some people won’t be eligible, such as those with MRI safety concerns (for example, certain implants, pregnancy, or severe claustrophobia) or with specific liver or kidney conditions, among other safety considerations.

If you join, you’ll start with a screening visit to review your health and give informed consent. Then you’ll have two study visits within 28 days: a baseline visit with standard health measurements and blood/urine tests, and a second visit for a multi-organ MRI scan. The study does not change your usual diabetes care. Researchers will also use your medical records to track hospital stays and mortality over 1, 3, and 5 years. The aim is to see whether the MRI findings can help predict events like heart problems, kidney issues, eye treatments for diabetic retinopathy, liver problems, or death, and to explore how eye disease severity relates to liver MRI metrics. There’s no guaranteed personal benefit, but findings could help doctors understand and monitor diabetes better in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female at least 18 years of age and diagnosed with type 2 diabetes, with or without diabetic retinopathy.
• • Participant willing and able to give informed consent for participation in the study.
• Exclusion Criteria:
• In 12 months prior to consent, evidence of existing cardiovascular event defined as at least one of:
• • myocardial infarction
• • ischaemic stroke
• • hospital admission/discharge for unstable angina
• • heart surgery
• • unstable angina
• • transient ischemic attack
• • The participant may not enter the study if they have any contraindication to magnetic resonance imaging (standard MR exclusion criteria including pregnancy, extensive tattoos, pacemaker, shrapnel injury, severe claustrophobia).
• • Patients with known autoimmune hepatitis, viral hepatitis, Wilson's disease or known significant structural renal tract abnormality.
• • Patients with known alcohol dependency.
• • Any other cause, including a significant disease or disorder which, in the opinion of the investigator, may either put the participant at risk because of participation in the study, or may influence the participant's ability to participate in the study