Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension

Launched by POST GRADUATE INSTITUTE OF MEDICAL EDUCATION AND RESEARCH, CHANDIGARH · Sep 26, 2021

Keywords

ClinConnect Summary

This clinical trial is examining how to best manage fluid therapy in patients with liver disease, specifically those who have cirrhosis and experience low blood pressure due to infections (a condition called sepsis). The goal is to find the most effective methods to assess how much fluid these patients need, as traditional methods may not work well for them due to the unique challenges posed by liver disease. By comparing different strategies for measuring fluid needs, the researchers hope to improve treatment and reduce the risk of complications.

To be eligible for the trial, participants must be between the ages of 18 and 65 and have been diagnosed with cirrhosis, along with low blood pressure. They should not have already received certain treatments, like large amounts of fluid or specific medications, before joining the study. Participants in the trial can expect to undergo various assessments related to their fluid needs and receive appropriate care based on the study findings. This research is important because it aims to enhance how we manage critically ill patients with liver disease, potentially leading to better outcomes for them.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Clinical/Imaging or Biopsy proven liver cirrhosis of any etiology
• • 2. Hypotension (MAP \<65mmHg or SBP \<90mmHg)
• • 3. 18-65 yrs of age
• Exclusion Criteria:
• • 1. Already received colloid or 2 litres of fluid within the first 2 hours of presentation, without echocardiographic assessment.
• • 2. Already on vasopressors/inotropes
• • 3. Severe pre-existing cardiopulmonary disease
• • 4. Acute Respiratory Distress Syndrome (ARDS)
• • 5. Active bleeding like variceal bleed 28
• • 6. Cerebrovascular events
• • 7. Chronic renal disease - End Stage Renal Disease (ESRD)/ patient on renal replacement therapy
• • 8. Admission to ICU following liver transplantation, burns, cardiac surgery
• • 9. Brain death or likely brain death within 24 hours
• • 10. Previous adverse reaction to human albumin solution
• • 11. Pregnant or lactating women
• • 12. Informed consent refused by patient or attendants