Multi-Domain Exercise and Memory in Adults Relative to ApoE Genotype: A fMRI Study

Launched by NATIONAL TAIWAN NORMAL UNIVERSITY · Sep 26, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how a specific exercise program can help improve memory and brain activity in adults aged 45 to 70 years. The researchers want to see if this exercise can have different effects based on a person's genetic makeup, particularly focusing on a gene called ApoE e4, which is linked to memory and aging. The study will last for six months and will involve participants being randomly assigned to either the exercise program or a control group.

To be eligible for this trial, participants must be able to read and speak Chinese, have normal or corrected vision, and achieve a certain score on a memory test. They should not have any significant cognitive issues, major psychiatric illnesses, or serious physical health problems. Those who join can expect to participate in exercise sessions and undergo brain scans to see how their memory and brain function change over time. This study is currently recruiting participants, and it's important for anyone interested to discuss their health history with the research team to ensure they can safely participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Normal or corrected-to-normal vision
• • Able to speak and read Chinese
• • Scores of Mini-Mental Status Examination \>= 25
• • Physical Activity Readiness Questionnaire score \< 0
• • Able to conduct the exercise with moderate intensity
• • Meet the criteria to undergo magnetic resonance imaging
• • Provide informed consent
• Exclusion Criteria:
• • Diagnosed or self-reported cognitive problems (e.g., mild cognitive impairment or dementia)
• • Diagnosed or self-reported physical disease (e.g., untreated hypertension and chronic heart disease, stroke, brain tumor, musculoskeletal disorders, other exercise contradictions)
• • Diagnosed or self-reported major psychiatric illness (e.g., major depression, schizophrenia)
• • Diagnosed or self-reported neurodegenerative disease (e.g., Alzheimer's disease and other dementias, Parkinson's disease (PD) and PD-related disorders, Huntington's disease)
• • History of alcohol or drug abuse
• • History of chemotherapy
• • Traveling consecutively for three weeks or more during the study
• • Unwillingness to be randomized to one of the two groups
• • Currently participating in another study trial
• Exclusion Criteria for functional magnetic resonance images (fMRI):
• • Participants will be excluded if s/he has a contraindication to fMRI scanning, such as aneurysm clip, implanted neural stimulator, cochlear implant, any implanted device, cardiac pacemaker. To ensure volunteers are eligible for the current project, they will be asked to fill out a questionnaire to inform whether they have conditions (e.g. paralyzed hemidiaphragm) or present unnecessary risks (e.g., pregnancy) during the recruitment period.