Application of Hyaluronic Acid in the Treatment of Periodontitis
Launched by FEDERICO II UNIVERSITY · Sep 28, 2021
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating how well hyaluronic acid can help heal specific gum defects in patients with periodontitis, a serious gum disease that can lead to tooth loss. The study will compare two groups of patients: one group will receive treatment with hyaluronic acid during their gum surgery, while the other group will have the surgery without this additional treatment. A total of 80 patients will be involved in the study, and they will be chosen based on certain criteria to ensure they are suitable for participation.
To be eligible for this trial, participants must be at least 18 years old and have been diagnosed with periodontitis. They should have certain types of periodontal defects that meet specific measurements after receiving initial non-surgical treatment. However, those with systemic diseases, recent antibiotic use, or who smoke heavily will not qualify. Participants can expect to undergo a surgical procedure, and they will be monitored to see how well their gums heal with or without the use of hyaluronic acid. This study is currently recruiting participants, and it aims to provide valuable information on improving treatments for gum disease.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Patients diagnosed with periodontitis
- • Age ≥ 18 years old
- • Single-rooted and multi-rooted teeth
- • Presence of suprabony periodontal defects at a minimum of two adjacent teeth and a maximum of 7 adjacent teeth in either the maxilla or the mandible with a PD ≥ 5 mm after completion of non-surgical periodontal treatment and re-evaluation
- • Intrabony defect with an intraosseous component \< 2 mm
- Exclusion Criteria:
- • Patients with systemic diseases
- • Prolonged antibiotic or anti-inflammatory treatment within 4 weeks prior to surgery
- • Pregnant or lactating
- • Tobacco smokers (≥ 10 cigarettes per day)
- • Multi-rooted teeth with furcation involvement
- • Increased tooth mobility (grade II and III)
About Federico Ii University
Federico II University, located in Naples, Italy, is a prestigious academic institution with a strong emphasis on advanced research and clinical innovation. As a clinical trial sponsor, the university is committed to fostering the development of novel therapeutic interventions and enhancing patient care through rigorous scientific inquiry. With a multidisciplinary approach, Federico II University collaborates with healthcare professionals, researchers, and industry partners to conduct high-quality clinical trials that adhere to ethical standards and regulatory requirements. Its dedication to improving health outcomes is reflected in its robust research programs and commitment to translating scientific findings into clinical practice.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Naples, , Italy
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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