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Search / Trial NCT05088187

Cognition and QoL After Thyroid Surgery

Launched by KAROLINSKA UNIVERSITY HOSPITAL · Oct 11, 2021

Trial Information

Current as of September 11, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is studying how thyroid surgery might affect thinking skills and quality of life in people who have thyroid nodules or thyroid cancer. Researchers want to understand if there are changes in cognitive function after surgery, how these changes relate to thyroid hormone levels, and how they affect patients' overall well-being. Participants will complete online tests to assess their cognitive abilities and fill out questionnaires about their quality of life, physical activity, and any other health concerns. They will also have blood tests to check hormone levels and inflammation.

To be eligible for the study, participants must be over 18 years old, have a thyroid nodule that needs surgery, and be able to read and understand Swedish. They should also have access to a computer with internet. However, individuals with certain previous health conditions, such as autoimmune hypothyroidism or other types of cancer, cannot participate. Those who join the study can expect to contribute valuable information that may help improve understanding of the long-term effects of thyroid surgery on cognitive health and quality of life.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Age \>18 years old, indication for surgery because of a thyroid nodule Bethesda IV-VI
  • Able to read and understand the Swedish language
  • Access to desktop computer or laptop with internet connection
  • Able and willing to provide written informed consent
  • Exclusion Criteria:
  • A previous diagnosis of (auto-immune) hypothyroidism
  • A previous cancer diagnosis (excluding basal cell cancer of the skin)
  • Indications for surgery other than (solely) a thyroid nodule (i.e., concomitant Graves)
  • A diagnosis of medullary and anaplastic thyroid cancer

About Karolinska University Hospital

Karolinska University Hospital is a leading academic medical center in Sweden, renowned for its commitment to advanced healthcare research and innovative clinical practices. As a key sponsor of clinical trials, the hospital leverages its extensive expertise in medical research and collaboration with Karolinska Institutet, one of the world's foremost medical universities. The institution is dedicated to enhancing patient care through rigorous scientific investigation, focusing on a wide range of therapeutic areas. With a multidisciplinary approach and a strong emphasis on translational medicine, Karolinska University Hospital aims to bridge the gap between laboratory findings and clinical application, ultimately striving to improve health outcomes and advance medical knowledge.

Locations

Stockholm, Sweden

Patients applied

0 patients applied

Trial Officials

Renske Altena, MD PhD

Principal Investigator

Karolinska Institutet

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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