Morning Versus Bedtime Dosing of Antihypertensive Medication

Launched by YAN LI · Oct 13, 2021

Keywords

ClinConnect Summary

This clinical trial is looking at whether taking blood pressure medication in the morning or at bedtime makes a difference in lowering blood pressure, especially at night. Researchers believe that controlling nighttime blood pressure is important for heart health, and they want to see if the timing of when people take their medication can help manage this better. The study will involve patients using both home and ambulatory (24-hour) blood pressure monitors to track their blood pressure levels throughout the day and night.

To be eligible for the trial, participants should be adults aged 18 to 70 who have high blood pressure but have not been treated for it before or have stopped their medications for at least two weeks. They should have specific blood pressure readings that fall within certain ranges. Participants can expect regular check-ups and monitoring during the trial to see how their blood pressure responds to the different dosing times. It’s also important to note that some health conditions could prevent someone from participating, so potential volunteers should discuss their medical history with their doctor.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male or female patients aged 18-70 years old;
• • 2. Never treated for hypertension or stopped using antihypertensive drugs for at least 2 weeks;
• • 3. In the two screenings,the clinical systolic BP should be in the range of 140-159 mmHg, the diastolic BP \< 100 mmHg;
• • 4. The average 24-hour systolic BP ≥130mmHg, daytime systolic BP ≥ 135 mmHg, and nighttime systolic BP ≥ 120 mmHg;
• • 5. The average of bilateral brachial-ankle pulse wave velocity ≥14m/s;
• • 6. Be willing to participate in the trial, sign the informed consent form, and be able to visit doctors by himself or herself.
• Exclusion Criteria:
• • 1. Secondary hypertension;
• • 2. Concomitant obstructive sleep apnea (STOP-BANG score ≥ 5), insomnia, Parkinson's syndrome, or nocturnal polyuria and other diseases that affect nighttime BP;
• • 3. Need to work at night;
• • 4. Ambulatory BP monitoring was invalid (\<70% valid readings, or \<20 daytime readings or \<7 nighttime readings);
• • 5. Concomitant diseases that need taking medications influencing BP;
• • 6. Coronary heart disease, myocardial infarction or stroke within recent 6 months;
• • 7. Atrial fibrillation or frequent arrhythmia;
• • 8. Abnormal liver function exemplified as an increased alanine transaminase (ALT), aspartate transaminase (AST), total bilirubin (TBL) over the double of the upper limit of normal range; abnormal renal function exemplified as a serum creatinine ≥176 µmol/L; and plasma potassium ≥5.5 mmol/L or ≤3.5mmol/L;
• • 9. Pregnant or lactating women;
• • 10. Contraindications of angiotensin II receptor blocker or calcium channel blocker;
• • 11. Other concomitant diseases which are considered not suitable to participate in the trial, such as thyroid diseases, acute infectious diseases, chronic mental diseases, tumor, etc.