Dietary Potassium Liberalization in Pre-Dialysis Patients

Launched by UNIVERSITY OF MANITOBA · Oct 12, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how the amount of potassium in fruits and vegetables affects the potassium levels in people with Chronic Kidney Disease (CKD). Participants will receive home deliveries of either high-potassium or low-potassium fruits and vegetables at different times. Throughout the study, researchers will check their blood and urine for certain markers, monitor their blood pressure, and assess their physical abilities and overall quality of life. This research has the potential to change dietary advice for those with CKD regarding potassium intake.

To join the study, participants need to be at least 18 years old, have specific kidney function levels, and a potassium level between 4.5 and 5.5 milliequivalents per liter (mEq/L). They also need to be receiving care at a nephrology clinic in Winnipeg and be able to understand and sign consent forms in English. Participants can expect to take part in simple tests to measure their physical functioning and will be closely monitored throughout the study to ensure their safety and well-being.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male or female, aged 18 years or above
• • Participants who have an estimated glomerular filtration rate between 15 and 45 ml/min/1.73m2
• • Serum potassium concentration between 4.5 and 5.5 milliequivalent (mEq)/L
• • Hemoglobin A1c ≤ 11%
• • Systolic and diastolic blood pressure \<160/100 mmHg
• • Are registered in the multidisciplinary nephrology clinic in Winnipeg
• • Able to communicate in English and provide written informed consent
• Exclusion Criteria:
• • Serum potassium concentration \> 5.6 mEq/L, anuria, dialysis, or acute kidney injury failure in the 6 months prior to screening
• • Chronic obstructive pulmonary disease that requires the participant to be on oxygen
• • New York Heart Association Class 3-4 Heart symptoms or heart, liver or renal transplant
• • A myocardial infarction or stroke within the last 6 months
• • Unable to consume study treatments or control, such as swallowing or gastro-intestinal issues
• • Currently on potassium binding therapy
• • In the opinion of the investigator any medical condition, uncontrolled systemic disease or concurrent illness that would decrease the study compliance or jeopardize the safety of the participant
• • Female participant who is pregnant or lactating