Is Obstructive Sleep Apnea Important in the Development of Alzheimer's Disease?

Launched by UNIVERSITY OF CALIFORNIA, SAN DIEGO · Oct 22, 2021

Keywords

ClinConnect Summary

This clinical trial is looking into how obstructive sleep apnea (OSA) might affect the development and progression of Alzheimer's disease. OSA is a common sleep disorder where a person's breathing repeatedly stops and starts during sleep, leading to poor sleep quality and memory problems. Researchers want to understand if having OSA increases the risk of developing Alzheimer's disease or makes it worse over time.

To participate in the study, you need to be between 65 and 85 years old, and you should be able to live independently and drive. Both men and women are welcome to join. You will need to have a specific score on a memory test (MOCA score above 26) and either have OSA or not. If you decide to take part, you'll be asked to complete some questionnaires and possibly undergo MRI scans to help with the research. It's important to note that some health conditions, like certain heart or lung diseases, may prevent you from participating. The study is currently recruiting participants, so if you or someone you know fits these criteria and is interested, you might want to consider getting involved!

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age 65-85 years
• • 2. Gender: Men or Women
• • 3. MOCA \> 26
• • 4. Independently living and able to drive
• • 5. OSA (AHI ≥ 15/h) or no OSA
• • 6. Subjects must consent to waiving their right to obtain their PHS score (since the score is not yet actionable and could lead to social stress and ethical dilemmas)
• Exclusion Criteria:
• • 1. Currently smoking
• • 2. History of COPD or asthma
• • 3. Heart Failure Class III or IV, unstable cardiovascular disease, or uncontrolled hypertension
• • 4. Neuromuscular Disease
• • 5. Drowsy Driving (ESS \> 18/24)
• • 6. Inability to complete study procedures, such as questionnaire that are only available/validated in English
• • 7. Lack of decisional capacity to provide informed consent
• • 8. Participants in whom magnetic resonance imaging Magnetic Resonance Imaging \[MRI\] is contraindicated including, but not limited to, those with a pacemaker, presence of metallic fragments near the eyes or spinal cord, or cochlear implant
• • 9. Presence of a brain tumor or lobar stroke
• • 10. Current drug or alcohol abuse/dependence
• • 11. Prisoners