Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Adult Patients With Uncontrolled Moderate to Severe Asthma
Launched by SANOFI · Oct 15, 2021
Trial Information
Current as of June 27, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is exploring how well a medication called dupilumab can help prevent lung function decline in adults who have moderate to severe asthma that isn't well controlled. The study will compare dupilumab to standard asthma treatments to see which one better helps maintain lung health over time. It will last about three years, with participants undergoing a screening period first and then receiving treatment in a way that keeps both the participants and researchers unaware of which treatment is given (this is called a "double-blind" study).
To be eligible for this trial, participants need to be at least 18 years old and have a doctor’s diagnosis of asthma for at least a year. They should have been using medium to high doses of certain asthma medications and show signs that their asthma is not well managed. Throughout the study, participants can expect regular check-ins and assessments to monitor their lung health and overall response to the treatment. This trial is currently recruiting participants, and it's important to note that people with certain other lung or serious health conditions, or those who have had recent severe asthma attacks, may not qualify.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Participant must be at least 18 (or the legal age of consent in the jurisdiction in which the study is taking place) years of age inclusive, at the time of signing the informed consent.
- • Patients with a physician diagnosis of asthma (according to Global Initiative for Asthma (GINA) 2021) for ≥12 months
- • Treatment with medium to high dose inhaled corticosteroids (ICS) in combination with a second controller (eg, long-acting beta-2 adrenergic receptor agonists (LABA), leukotriene receptor antagonists (LTRA) with a stable dose ≥1 month prior to Visit 1. Patients requiring a third controller for their asthma will be considered eligible for this study, and it should also be on stable dose ≥1 month prior to Visit 1. Patients requiring an additional controller as a fourth controller (Montelukast) for another type 2 comorbid condition such as allergic rhinitis will be considered eligible for this study, and should be on a stable dose for ≥1 month prior to Visit 1.
- • Pre-bronchodilator forced expiratory volume (FEV1) ≤ 80% of predicted normal for adults at Visits 1 and 2, prior to randomization
- • Asthma Control Questionnaire 5-question version (ACQ-5) score ≥1.5 at Visits 1 and 2, prior to randomization.
- * Variable airflow obstruction as documented by one or more of the following (at least 1 needs to be met):
- • i) Positive reversibility test: ≥12% and 200 mL improvement in FEV1 after SABA administration prior to randomization, or documented in the 24 months prior to Visit 1. OR, ii) Positive bronchial challenge test: fall in FEV1 of ≥20% with standard doses of methacholine, or ≥15% with standardized hyperventilation, hypertonic saline or mannitol challenge prior to randomization or documented in the 24 months prior to Visit 1 OR, iii) Average daily diurnal Peak flow variability of \>10% over a 2-week period, documented in the past 24 months prior to Screening Visit 1. OR, iv) Airflow variability in clinic FEV1 \>12% and 200 mL between visits outside of respiratory infections, documented in the past 24 months prior to Screening Visit 1. OR v) FEV1 increases by more than 12% and 200mL from baseline after 4 weeks of anti-inflammatory treatment.
- • Reversibility test: Three attempts may be made during the Screening Period until the Baseline visit to meet the qualifying criteria for reversibility. This is only required if reversibility or other evidence of expiratory airflow limitation eligibility criteria was not performed within 24 months prior to Visit 1.
- • FeNO ≥35 ppb at Visit 2, prior to randomization.
- * History of ≥1 severe exacerbation(s) in the previous year before Visit1 defined as a deterioration of asthma requiring:
- • i) Use of systemic corticosteroids for ≥3 days; or ii) Hospitalization or emergency room visit because of asthma, requiring systemic corticosteroids.
- Exclusion Criteria:
- Participants are excluded from the study if any of the following criteria apply:
- • History or clinical evidence of chronic obstructive pulmonary disease (COPD) including Asthma-COPD Overlap Syndrome (ACOS) or any other significant lung disease (eg, emphysema, lung fibrosis, sarcoidosis, interstitial lung disease, pulmonary hypertension, bronchiectasis, Churg-Strauss Syndrome).
- • Severe asthma exacerbation requiring treatment with systemic corticosteroid (SCS) in the past month before visit 1 or during the screening period.
- • Current acute bronchospasm or status asthmaticus.
- • Diagnosed pulmonary (other than asthma) or systemic disease associated with elevated peripheral eosinophil counts.
- • Severe concomitant illness(es) that, in the Investigator's judgment, would adversely affect the participant's participation in the study. Examples include, but are not limited to, participants with short life expectancy, uncontrolled diabetes, cardiovascular conditions, severe renal conditions (eg, participants on dialysis), or other severe endocrinological, gastrointestinal, metabolic, pulmonary, psychiatric, or lymphatic diseases. The specific justification for participants excluded under this criterion will be noted in the study documents (chart notes, case report forms \[CRFs\], etc).
- • Patients with active tuberculosis (TB) or non-tuberculous mycobacterial infection, or a history of incompletely treated TB will be excluded from the study unless it is well documented by a specialist that the participant has been adequately treated and can now start treatment with a biologic agent, in the medical judgment of the Investigator and/or infectious disease specialist. Tuberculosis testing will be performed on a country by country basis, according to local guidelines if required by regulatory authorities or ethics boards, or if TB is suspected by the investigator
- • Known or suspected immunodeficiency, including history of invasive opportunistic infections (eg, histoplasmosis, listeriosis, coccidioidomycosis, pneumocystosis, and aspergillosis) despite infection resolution, or otherwise recurrent infections of abnormal frequency or prolonged duration suggesting an immune-compromised status, as judged by the Investigator.
- • Active malignancy or history of malignancy within 5 years before Visit 1 (screening visit), except completely treated in situ carcinoma of the cervix and completely treated and resolved non metastatic squamous or basal cell carcinoma of the skin.
- • Active chronic or acute infection requiring treatment with systemic antibiotics, antivirals, antifungals or receiving only symptomatic treatment (e.g. influenza or COVID-19) within 2 weeks before the screening visit (Visit 1) or during the screening period.
- • History of human immunodeficiency virus (HIV) infection or positive HIV 1/2 serology at Visit 1 (screening visit).
- • Diagnosed with, suspected of, or at high risk of endoparasitic infection, and/or use of antiparasitic drugs within 2 weeks before Visit 1 (screening visit) or during the screening and run-in period
- • Current smoker (cigarette or e-cigarette) or cessation of smoking within 6 months prior to Visit 1.
- • Previous smoker with a smoking history \>10 pack-years.
- • History of systemic hypersensitivity or anaphylaxis to dupilumab or any other biologic therapy, including any excipient.
- • Any biologic therapy (including experimental treatments and dupilumab) or any other biologic therapy/immunosuppressant/immunomodulators within 4 weeks prior to V1 or 5 half-lives, whichever is longer.
- • Treatment with a live (attenuated) vaccine within 4 weeks before Visit 1 (screening visit) or during the screening period.
- • The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
About Sanofi
Sanofi is a global healthcare leader dedicated to empowering life through innovation in pharmaceuticals and vaccines. With a strong commitment to research and development, Sanofi focuses on addressing complex health challenges across various therapeutic areas, including diabetes, oncology, immunology, and rare diseases. The company leverages advanced science and technology to develop transformative therapies that improve patient outcomes. Through collaborative partnerships and a patient-centric approach, Sanofi strives to enhance global health and deliver sustainable solutions that meet the evolving needs of healthcare systems and communities worldwide.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Leuven, , Belgium
Bruxelles, , Belgium
Cape Town, , South Africa
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Guadalajara, Jalisco, Mexico
Levice, , Slovakia
Poprad, , Slovakia
Spisska Nova Ves, , Slovakia
Istanbul, , Turkey
Liège, , Belgium
Veracruz, , Mexico
Sofia, , Bulgaria
Athens, , Greece
Százhalombatta, , Hungary
Izmir, , Turkey
Edelény, , Hungary
Hajdúnánás, , Hungary
Püspökladány, , Hungary
Mersin, , Turkey
Durango, , Mexico
Quebec, , Canada
Newcastle Upon Tyne, , United Kingdom
Cullman, Alabama, United States
Sheffield, Alabama, United States
Tucson, Arizona, United States
Bakersfield, California, United States
Fullerton, California, United States
Newport Beach, California, United States
Westminster, California, United States
Altamonte Springs, Florida, United States
Aventura, Florida, United States
Brandon, Florida, United States
Debary, Florida, United States
Kissimmee, Florida, United States
Miami Lakes, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Orlando, Florida, United States
Atlanta, Georgia, United States
Owensboro, Kentucky, United States
Crowley, Louisiana, United States
Annapolis, Maryland, United States
White Marsh, Maryland, United States
Fall River, Massachusetts, United States
Ann Arbor, Michigan, United States
Dearborn, Michigan, United States
Lathrup Village, Michigan, United States
Rochester, Michigan, United States
Southfield, Michigan, United States
Ypsilanti, Michigan, United States
Bellevue, Nebraska, United States
New Windsor, New York, United States
Westfield, New York, United States
Charlotte, North Carolina, United States
Gastonia, North Carolina, United States
Huntersville, North Carolina, United States
Mooresville, North Carolina, United States
Toledo, Ohio, United States
Tulsa, Oklahoma, United States
Philadelphia, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Charleston, South Carolina, United States
Columbia, South Carolina, United States
Greenville, South Carolina, United States
Rapid City, South Dakota, United States
Boerne, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Mckinney, Texas, United States
Mckinney, Texas, United States
Tomball, Texas, United States
Norfolk, Virginia, United States
Moncton, New Brunswick, Canada
Niagara Falls, Ontario, Canada
Toronto, Ontario, Canada
Toronto, Ontario, Canada
Toronto, Ontario, Canada
Montreal, Quebec, Canada
Windsor, , Canada
Palaio Faliro, Athens, , Greece
Mosonmagyaróvár, , Hungary
Busan, Busan Gwangyeoksi, Korea, Republic Of
Daegu, Daegu Gwangyeoksi, Korea, Republic Of
Wonju, Gangwon Do, Korea, Republic Of
Incheon, , Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Monterrey, , Mexico
Benoni, , South Africa
Pretoria, , South Africa
Ankara, , Turkey
Ankara, , Turkey
Balcali Adana, , Turkey
Kirikkale, , Turkey
Bradford, , United Kingdom
Athens, , Greece
Little River, South Carolina, United States
Dallas, Texas, United States
Houston, Texas, United States
Kingston, Ontario, Canada
Greece, , Greece
Debrecen, , Hungary
Hajdunánás, , Hungary
Monterrey, Nuevo León, Mexico
San Juan, , Puerto Rico
Rimavska Sobota, , Slovakia
Topolcany, , Slovakia
Cape Town, , South Africa
Durban, , South Africa
Gatesville, , South Africa
Johannesburg, , South Africa
Pretoria, , South Africa
Vereeniging, , South Africa
Woodstock, Georgia, United States
Ajax, Ontario, Canada
Mississauga, Ontario, Canada
Thessaloniki, , Greece
Chihuahua, Ciudad De Mexico, Mexico
Oxaca, Ciudad De Mexico, Mexico
Monterrey, Nuevo León, Mexico
Porto Alegre, Rio Grande Do Sul, Brazil
Monterrey, Nuevo León, Mexico
Tempe, Arizona, United States
Rancho Cucamonga, California, United States
Dunwoody, Georgia, United States
Southfield, Michigan, United States
Bethlehem, Pennsylvania, United States
Beaumont, Texas, United States
Charlottesville, Virginia, United States
Kelowna, British Columbia, Canada
Athens, , Greece
Athens, , Greece
Ioannina, , Greece
N. Efkarpia, , Greece
Budapest, , Hungary
Ahmedabad, , India
Coimbatore, , India
Faridabad, , India
Jaipur, , India
Kozhikode, , India
Lucknow, , India
Mangalore, , India
Nagpur, , India
Nagpur, , India
San Juan Del Rio, Querétaro, Mexico
Mexico, , Mexico
Guaynabo, , Puerto Rico
Parow, , South Africa
Kaohsiung, , Taiwan
Taipei, , Taiwan
Yunlin, , Taiwan
Cape Town, , South Africa
Chandler, Arizona, United States
Cutler Bay, Florida, United States
Houston, Texas, United States
San Antonio, Texas, United States
Sao Paulo, São Paulo, Brazil
Dupnitsa, , Bulgaria
Ruse, , Bulgaria
Athens, , Greece
Athens, , Greece
New Delhi, , India
Vadodara, , India
New Taipei City, , Taiwan
Taichung, , Taiwan
Liverpool, , United Kingdom
Sao Paulo, São Paulo, Brazil
Puspokladany, , Hungary
Szombathely, , Hungary
Savannah, Georgia, United States
Skokie, Illinois, United States
Blumenau, Santa Catarina, Brazil
Montana, , Bulgaria
Chandigarh, , India
Mysore, , India
Durban, , South Africa
Cambridge, Cambridgeshire, United Kingdom
Beverly Hills, California, United States
Tampa, Florida, United States
Adairsville, Georgia, United States
Bronx, New York, United States
Hickory, North Carolina, United States
Winston Salem, North Carolina, United States
Belo Horizonte, Minas Gerais, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Vancouver, British Columbia, Canada
Athens, , Greece
Athens, , Greece
Budapest, , Hungary
Szekszard, , Hungary
Mumbai, , India
Mysore, , India
Wilton, Cork, Ireland
San Juan, , Puerto Rico
Gauteng, , South Africa
Abu Dhabi, , United Arab Emirates
Wakefield, Leeds, United Kingdom
Leuven, , Belgium
Liège, , Belgium
Sint Lambrechts Woluwe, , Belgium
Porto Alegre, Rio Grande Do Sul, Brazil
Brasov, , Romania
Newcastle Upon Tyne, , United Kingdom
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Bragadiru, , Romania
Levice, , Slovakia
Edelény, , Hungary
Hajdunánás, , Hungary
Puspokladany, , Hungary
Százhalombatta, , Hungary
Monterrey, Nuevo León, Mexico
Cape Town, , South Africa
Ankara, , Turkey
Mersin, , Turkey
Szombathely, , Hungary
Bradford, , United Kingdom
Sao Paulo, São Paulo, Brazil
Thessaloniki, , Greece
Kayseri, , Turkey
Athens, , Greece
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Cullman, Alabama, United States
Sheffield, Alabama, United States
Chandler, Arizona, United States
Phoenix, Arizona, United States
Tempe, Arizona, United States
Tucson, Arizona, United States
Bakersfield, California, United States
Beverly Hills, California, United States
Fullerton, California, United States
Newport Beach, California, United States
Orange, California, United States
Rancho Cucamonga, California, United States
Westminster, California, United States
Altamonte Springs, Florida, United States
Aventura, Florida, United States
Cutler Bay, Florida, United States
Debary, Florida, United States
Kissimmee, Florida, United States
Miami Lakes, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Orlando, Florida, United States
Tampa, Florida, United States
Adairsville, Georgia, United States
Dunwoody, Georgia, United States
Savannah, Georgia, United States
Chicago, Illinois, United States
Skokie, Illinois, United States
Louisville, Kentucky, United States
Owensboro, Kentucky, United States
Crowley, Louisiana, United States
Annapolis, Maryland, United States
White Marsh, Maryland, United States
Fall River, Massachusetts, United States
Ann Arbor, Michigan, United States
Dearborn, Michigan, United States
Lathrup Village, Michigan, United States
Rochester, Michigan, United States
Southfield, Michigan, United States
Ypsilanti, Michigan, United States
Bellevue, Nebraska, United States
Jersey City, New Jersey, United States
Bronx, New York, United States
Gastonia, North Carolina, United States
Hickory, North Carolina, United States
Huntersville, North Carolina, United States
Mooresville, North Carolina, United States
Winston Salem, North Carolina, United States
Toledo, Ohio, United States
Tulsa, Oklahoma, United States
Bethlehem, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Charleston, South Carolina, United States
Columbia, South Carolina, United States
Greenville, South Carolina, United States
Little River, South Carolina, United States
Rapid City, South Dakota, United States
Beaumont, Texas, United States
Boerne, Texas, United States
Dallas, Texas, United States
Denton, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Mckinney, Texas, United States
Mckinney, Texas, United States
San Antonio, Texas, United States
Tomball, Texas, United States
Charlottesville, Virginia, United States
Belo Horizonte, Minas Gerais, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Blumenau, Santa Catarina, Brazil
Sao Paulo, São Paulo, Brazil
Sorocaba, São Paulo, Brazil
Dupnitsa, , Bulgaria
Montana, , Bulgaria
Plovdiv, , Bulgaria
Ruse, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Vratsa, , Bulgaria
Kelowna, British Columbia, Canada
Vancouver, British Columbia, Canada
Moncton, New Brunswick, Canada
Ajax, Ontario, Canada
Kingston, Ontario, Canada
Mississauga, Ontario, Canada
Niagara Falls, Ontario, Canada
Toronto, Ontario, Canada
Toronto, Ontario, Canada
Toronto, Ontario, Canada
Montreal, Quebec, Canada
Montreal, Quebec, Canada
Quebec, , Canada
Windsor, , Canada
Athens, , Greece
Athens, , Greece
Athens, , Greece
Athens, , Greece
Athens, , Greece
Ioannina, , Greece
N. Efkarpia, , Greece
Palaio Faliro, Athens, , Greece
Budapest, , Hungary
Budapest, , Hungary
Debrecen, , Hungary
Mosonmagyaróvár, , Hungary
Szekszard, , Hungary
Ahmedabad, , India
Chandigarh, , India
Coimbatore, , India
Faridabad, , India
Jaipur, , India
Kozhikode, , India
Lucknow, , India
Mangalore, , India
Mumbai, , India
Mysore, , India
Mysore, , India
Nagpur, , India
Nagpur, , India
New Delhi, , India
Vadodara, , India
Wilton, Cork, Ireland
Dublin 4, Dublin, Ireland
Busan, Busan Gwangyeoksi, Korea, Republic Of
Daegu, Daegu Gwangyeoksi, Korea, Republic Of
Wonju, Gangwon Do, Korea, Republic Of
Incheon, , Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Chihuahua, Ciudad De Mexico, Mexico
Oxaca, Ciudad De Mexico, Mexico
Guadalajara, Jalisco, Mexico
Monterrey, Nuevo León, Mexico
San Juan Del Rio, Querétaro, Mexico
Durango, , Mexico
Mexico, , Mexico
Veracruz, , Mexico
Muscat, , Oman
Muscat, , Oman
Guaynabo, , Puerto Rico
San Juan, , Puerto Rico
San Juan, , Puerto Rico
Brasov, , Romania
Codlea, , Romania
Deva, , Romania
Pitesti, , Romania
Riyadh, , Saudi Arabia
Poprad, , Slovakia
Spisska Nova Ves, , Slovakia
Topolcany, , Slovakia
Benoni, , South Africa
Cape Town, , South Africa
Chatsworth, , South Africa
Durban, , South Africa
Durban, , South Africa
Gatesville, , South Africa
Gauteng, , South Africa
Johannesburg, , South Africa
Pretoria, , South Africa
Kaohsiung, , Taiwan
New Taipei City, , Taiwan
Taichung, , Taiwan
Taipei, , Taiwan
Yunlin, , Taiwan
Ankara, , Turkey
Balcali Adana, , Turkey
Istanbul, , Turkey
Izmir, , Turkey
Kirikkale, , Turkey
Abu Dhabi, , United Arab Emirates
Cambridge, Cambridgeshire, United Kingdom
Wakefield, Leeds, United Kingdom
Oxford, Oxfordshire, United Kingdom
Bradford, , United Kingdom
Liverpool, , United Kingdom
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Huntington Beach, California, United States
Upland, California, United States
Indianapolis, Indiana, United States
Metairie, Louisiana, United States
Columbia, Maryland, United States
Burke, Virginia, United States
Montana, , Bulgaria
Vancouver, British Columbia, Canada
Sherbrooke, Quebec, Canada
Timisoara, , Romania
Brussels, , Belgium
Sacramento, California, United States
Woodland, California, United States
Southfield, Michigan, United States
Beaumont, Texas, United States
Jodhpur, , India
Busan, Busan Gwangyeoksi, Korea, Republic Of
Ioannina, , Greece
Somerset West, , South Africa
Mooresville, North Carolina, United States
Montreal, Quebec, Canada
Montreal, Quebec, Canada
Villahermosa, Tabasco, Mexico
Makkah, , Saudi Arabia
Saskatoon, Saskatchewan, Canada
Monterrey, , Mexico
Nagpur, , India
Lima, , Peru
Presov, , Slovakia
Cape Town, , South Africa
Kempton Park, , South Africa
Abu Dhabi, , United Arab Emirates
Mckinney, Texas, United States
Cullman, Alabama, United States
Sheffield, Alabama, United States
Chandler, Arizona, United States
Phoenix, Arizona, United States
Tempe, Arizona, United States
Tucson, Arizona, United States
Bakersfield, California, United States
Beverly Hills, California, United States
Fullerton, California, United States
Huntington Beach, California, United States
Newport Beach, California, United States
Orange, California, United States
Rancho Cucamonga, California, United States
Sacramento, California, United States
Upland, California, United States
Westminster, California, United States
Woodland, California, United States
Altamonte Springs, Florida, United States
Aventura, Florida, United States
Cutler Bay, Florida, United States
Debary, Florida, United States
Doral, Florida, United States
Kissimmee, Florida, United States
Miami Lakes, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Miami, Florida, United States
Orlando, Florida, United States
Tampa, Florida, United States
Calhoun, Georgia, United States
Dunwoody, Georgia, United States
Savannah, Georgia, United States
Chicago, Illinois, United States
Skokie, Illinois, United States
Indianapolis, Indiana, United States
Louisville, Kentucky, United States
Owensboro, Kentucky, United States
Crowley, Louisiana, United States
Metairie, Louisiana, United States
Annapolis, Maryland, United States
Columbia, Maryland, United States
White Marsh, Maryland, United States
Fall River, Massachusetts, United States
Ann Arbor, Michigan, United States
Lathrup Village, Michigan, United States
Rochester, Michigan, United States
Southfield, Michigan, United States
Ypsilanti, Michigan, United States
Bellevue, Nebraska, United States
Jersey City, New Jersey, United States
Bronx, New York, United States
Gastonia, North Carolina, United States
Hickory, North Carolina, United States
Huntersville, North Carolina, United States
Mooresville, North Carolina, United States
Winston Salem, North Carolina, United States
Toledo, Ohio, United States
Tulsa, Oklahoma, United States
Bethlehem, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Columbia, South Carolina, United States
Greenville, South Carolina, United States
Little River, South Carolina, United States
North Charleston, South Carolina, United States
Rapid City, South Dakota, United States
Beaumont, Texas, United States
Boerne, Texas, United States
Dallas, Texas, United States
Denton, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Mckinney, Texas, United States
San Antonio, Texas, United States
Tomball, Texas, United States
Burke, Virginia, United States
Charlottesville, Virginia, United States
Belo Horizonte, Minas Gerais, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Porto Alegre, Rio Grande Do Sul, Brazil
Blumenau, Santa Catarina, Brazil
Sorocaba, São Paulo, Brazil
São Paulo, , Brazil
São Paulo, , Brazil
Vratsa, , Bulgaria
Mississauga, Ontario, Canada
Quebec City, Quebec, Canada
Saskatoon, Saskatchewan, Canada
Athens, , Greece
Athens, , Greece
Athens, , Greece
Athens, , Greece
Athens, , Greece
Palaio Faliro, , Greece
Thessaloniki, , Greece
Thessaloniki, , Greece
Budapest, , Hungary
Hajdúnánás, , Hungary
Püspökladány, , Hungary
Ahmedabad, , India
Mangaluru, , India
Mysuru, , India
Pune, , India
Cork, , Ireland
Dublin, , Ireland
Daegu, Daegu Gwangyeoksi, Korea, Republic Of
Wonju Si, Gangwon Do, Korea, Republic Of
Bupyeong Gu, , Korea, Republic Of
Seoul, Seoul Teukbyeolsi, Korea, Republic Of
Chihuahua, Ciudad De Mexico, Mexico
Mexico City, Ciudad De Mexico, Mexico
Oaxaca, Ciudad De Mexico, Mexico
Monterrey, Nuevo León, Mexico
San Juan Del Río, Querétaro, Mexico
Chihuahua, , Mexico
Muscat, , Oman
Lima, , Peru
Guaynabo, , Puerto Rico
San Juan, , Puerto Rico
San Juan, , Puerto Rico
Baia Mare, , Romania
Brașov, , Romania
Craiova, , Romania
Levice, , Slovakia
Prešov, , Slovakia
Spišská Nová Ves, , Slovakia
Topoľčany, , Slovakia
Cape Town, , South Africa
Cape Town, , South Africa
Chatsworth, , South Africa
Johannesburg, , South Africa
Douliu, , Taiwan
Kaohsiung City, , Taiwan
Taichung, , Taiwan
Taipei City, , Taiwan
Cambridge, Cambridgeshire, United Kingdom
Wakefield, Leeds, United Kingdom
Oxford, Oxfordshire, United Kingdom
Chandler, Arizona, United States
Phoenix, Arizona, United States
Dunwoody, Georgia, United States
Metairie, Louisiana, United States
Dearborn, Michigan, United States
Jersey City, New Jersey, United States
Little River, South Carolina, United States
Ningbo, , China
Ningbo, , China
Shanghai, , China
Hajdunã¡Nã¡S, , Hungary
Szekszárd, , Hungary
Lima, , Peru
Piura, , Peru
Vereeniging, , South Africa
Veracruz, , Mexico
Cullman, Alabama, United States
Phoenix, Arizona, United States
Upland, California, United States
Annapolis, Maryland, United States
Lathrup Village, Michigan, United States
Mooresville, North Carolina, United States
Dallas, Texas, United States
Houston, Texas, United States
Tomball, Texas, United States
Porto Alegre, Rio Grande Do Sul, Brazil
Kelowna, British Columbia, Canada
Nanchang, , China
Nanjing, , China
Yichang, , China
Pitești, , Romania
Mecca, , Saudi Arabia
Pretoria, , South Africa
Kirikkale, , Turkey
Chandler, Arizona, United States
Beijing, , China
Guangzhou, , China
Hebei, , China
Ningbo, , China
Taiyuan, , China
Tianjin, , China
Tianjin, , China
Wuxi, , China
Xi An, , China
Beaumont, Texas, United States
Beijing, , China
Bengbu, , China
Dongguan, , China
Xiamen, , China
North Charleston, South Carolina, United States
Calgary, Alberta, Canada
Yueyang, , China
Skokie, Illinois, United States
Dallas, Texas, United States
Plovdiv, , Bulgaria
Windsor, Ontario, Canada
Luzhou, , China
Daegu, Gyeongsangbuk Do, Korea, Republic Of
Chihuahua, , Mexico
Oaxaca, , Mexico
Wakefield, , United Kingdom
Beijing, , China
Guiyang, , China
Sorocaba, , Brazil
Bupyeong Gu, Incheon Gwangyeoksi, Korea, Republic Of
Monterrey, , Mexico
San Juan Del Río, , Mexico
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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