A Study of Zanubrutinib Plus Anti-CD20 Versus Lenalidomide Plus Rituximab in Participants With Relapsed/Refractory Follicular or Marginal Zone Lymphoma
Launched by BEIGENE · Oct 21, 2021
Trial Information
Current as of June 26, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying two different treatment combinations for patients with certain types of lymphoma that have returned or not responded to previous treatments. The first combination being tested is zanubrutinib and obinutuzumab, while the second combination is lenalidomide and rituximab. The goal of the study is to see which combination helps patients live longer without their disease getting worse, based on specific medical imaging tests.
To be eligible for the trial, participants should be aged between 65 and 74 and have a confirmed diagnosis of follicular lymphoma or marginal zone lymphoma. They must have received at least one prior treatment that included an anti-CD20 therapy but did not respond well. Participants should also have measurable disease, meaning doctors can see the cancer on scans, and they need to have good overall health, particularly in their bone marrow, liver, and kidneys. If someone joins the trial, they will be monitored closely to see how well the treatment works and if it helps manage their lymphoma.
Gender
ALL
Eligibility criteria
- Key Inclusion Criteria:
- • Histologically confirmed grade 1-3a FL or MZL
- • Previously treated with ≥ 1 line of systemic therapy including anti-CD20 agent. Must have a documented failure to achieve at least partial response during the most recent systemic therapy or documented progressive disease after the most recent systemic therapy
- • Need for systemic therapy for FL or MZL
- • Measurable disease by computed tomography or magnetic resonance imaging
- • Adequate bone marrow, liver and renal function
- Key Exclusion Criteria:
- • Transformation to aggressive lymphoma
- • Requiring ongoing need for corticosteroid treatment
- • Clinically significant cardiovascular disease
- • Prior malignancy within the past 2 years
- • Active fungal, bacterial, and/or viral infection that requires systemic therapy
- • Prior treatment with lenalidomide or drug from same class, if without response (partial or complete) or short remission duration (\< 24 months)
- • Note: Other protocol defined Inclusion/Exclusion criteria may apply.
About Beigene
BeiGene is a global biotechnology company focused on discovering, developing, and commercializing innovative medicines for the treatment of cancer. With a robust pipeline of targeted therapies and immuno-oncology agents, BeiGene is dedicated to advancing precision medicine to improve patient outcomes. The company integrates cutting-edge research, clinical development, and manufacturing capabilities to deliver transformative therapies across diverse oncology indications. Committed to addressing unmet medical needs, BeiGene collaborates with healthcare professionals and institutions worldwide to accelerate the development of its product candidates and enhance the lives of patients battling cancer.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Seattle, Washington, United States
Varese, , Italy
Milano, , Italy
Detroit, Michigan, United States
Saskatoon, Saskatchewan, Canada
New Orleans, Louisiana, United States
Westmead, New South Wales, Australia
Padova, , Italy
Perth, Western Australia, Australia
Madrid, , Spain
Concord, New South Wales, Australia
Seoul, , Korea, Republic Of
Nashville, Tennessee, United States
Syracuse, New York, United States
Houston, Texas, United States
Detroit, Michigan, United States
London, Ontario, Canada
Port Macquarie, New South Wales, Australia
Essen, , Germany
Melbourne, Victoria, Australia
Salamanca, , Spain
Zurich, , Switzerland
Jacksonville, Florida, United States
Huddersfield, , United Kingdom
Petach Tikva, , Israel
Cape Town, , South Africa
Plymouth, , United Kingdom
Curitiba, , Brazil
Hamilton, Ontario, Canada
Wichita, Kansas, United States
Halifax, Nova Scotia, Canada
Gosford, New South Wales, Australia
Berlin, , Germany
Lexington, Kentucky, United States
Southampton, , United Kingdom
Heidelberg, Victoria, Australia
Kogarah, New South Wales, Australia
Granada, , Spain
Seoul, , Korea, Republic Of
Gent, , Belgium
Kashiwa, Chiba, Japan
Sapporo, Hokkaido, Japan
Paris, , France
Madrid, , Spain
Leuven, , Belgium
Doetinchem, , Netherlands
Rotterdam, , Netherlands
Sevilla, , Spain
Glasgow, , United Kingdom
Kumamoto, , Japan
Petach Tikva, , Israel
Las Vegas, Nevada, United States
Nanjing, Jiangsu, China
Hradec Kralove, , Czechia
Fitzroy, Victoria, Australia
Beijing, , China
Istanbul, , Turkey
Vienna, , Austria
Cadiz, , Spain
Wichita, Kansas, United States
Osakasayama, Osaka, Japan
Changchun, Jilin, China
Okayama, , Japan
Ulm, , Germany
Syracuse, New York, United States
Newcastle Upon Tyne, , United Kingdom
Laval, Quebec, Canada
Izmir, , Turkey
Jerusalem, , Israel
Dalian, Liaoning, China
Beijing, Beijing, China
Hangzhou, Zhejiang, China
Shenyang, Liaoning, China
Brugge, , Belgium
Chengdu, Sichuan, China
Shanghai, Shanghai, China
Richmond, Virginia, United States
Wels, , Austria
Fuzhou, Fujian, China
Warszawa, Mazowieckie, Poland
Harbin, Heilongjiang, China
Zhengzhou, Henan, China
Le Mans, , France
Beijing, Beijing, China
Spokane, Washington, United States
Suzhou, Jiangsu, China
Shanghai, Shanghai, China
Leeds, , United Kingdom
Burgos, , Spain
York, Pennsylvania, United States
London, , United Kingdom
Anderlecht, , Belgium
Iasi, , Romania
Almere, , Netherlands
Harbin, Heilongjiang, China
Madrid, , Spain
Wuhan, Hubei, China
Malvern, Victoria, Australia
Wien, , Austria
Berlin, , Germany
Ramat Gan, , Israel
Xiamen, Fujian, China
Wenzhou, Zhejiang, China
London, , United Kingdom
Las Vegas, Nevada, United States
Braga, , Portugal
Watertown, South Dakota, United States
Nanchang, Jiangxi, China
Fort Wayne, Indiana, United States
Fitzroy, Victoria, Australia
Porto, , Portugal
Athens, , Greece
Alexandroupolis, , Greece
Lanzhou, Gansu, China
Toledo, Ohio, United States
Chongqing, Chongqing, China
Olomouc, , Czechia
Clayton, Victoria, Australia
Wuhan, Hubei, China
Badalona, , Spain
Jinhua, Zhejiang, China
Wuxi, Jiangsu, China
Afula, , Israel
Kocaeli, , Turkey
Bucharest, , Romania
Decatur, Illinois, United States
Hirakata, Osaka, Japan
Leon, , Spain
Billings, Montana, United States
Berlin, , Germany
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Los Angeles, California, United States
Katowice, , Poland
Patras, , Greece
Soweto, , South Africa
Ramat Gan, , Israel
Weihai, Shandong, China
Murcia, , Spain
Florham Park, New Jersey, United States
Pilar, , Argentina
Galway, , Ireland
New Orleans, Louisiana, United States
Incheon, , Korea, Republic Of
San Diego, California, United States
Baltimore, Maryland, United States
Baltimore, Maryland, United States
Taiyuan, Shanxi, China
Bournemouth, , United Kingdom
Milano, , Italy
Annapolis, Maryland, United States
Novara, , Italy
East Setauket, New York, United States
Los Alamitos, California, United States
West Perth, Western Australia, Australia
Shreveport, Louisiana, United States
Springfield, Missouri, United States
Zutphen, , Netherlands
Ramat Gan, , Israel
Porto Alegre, , Brazil
Basel, , Switzerland
Shenyang, Liaoning, China
Waterford, , Ireland
Seoul, Gyeonggi Do, Korea, Republic Of
Madrid, , Spain
Buenos Aires, , Argentina
Pozuelo De Alarcon, , Spain
Guangzhou, Guangdong, China
Melbourne, Victoria, Australia
Izmir, , Turkey
Los Angeles, California, United States
Hattiesburg, Mississippi, United States
Pensacola, Florida, United States
Westbury, New York, United States
Zhanjiang, Guangdong, China
Blumenau, , Brazil
Ankara, , Turkey
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Jiaxing, Zhejiang, China
Firenze, , Italy
Lanzhou, Gansu, China
Roosendaal, , Netherlands
Douglas, Queensland, Australia
Cleveland, Ohio, United States
Grosse Pointe Woods, Michigan, United States
Ashdod, , Israel
Irvine, California, United States
Wien, , Austria
Ede, , Netherlands
Burgos, , Spain
Westbury, New York, United States
Sofia, , Bulgaria
Strasbourg, , France
Foshan, Guangdong, China
Batumi, , Georgia
Tbilisi, , Georgia
Ulm, , Germany
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Athens, , Greece
Niteroi, , Brazil
Innsbruck, , Austria
Bethesda, Maryland, United States
Grand Island, Nebraska, United States
Wuhu, Anhui, China
Ganzhou, Jiangxi, China
Rio De Janeiro, , Brazil
Taian, Shandong, China
Los Angeles, California, United States
East Melbourne, Victoria, Australia
Rio De Janeiro, , Brazil
Anyang, Henan, China
Paris, , France
Omaha, Nebraska, United States
Des Moines, Iowa, United States
Puyallup, Washington, United States
Tampa, Florida, United States
Cincinnati, Ohio, United States
Tyler, Texas, United States
Krakow, , Poland
York, Pennsylvania, United States
Anyang, Henan, China
Gosford, New South Waled, Australia
Birtinya, Queensland, Australia
Malvern, Victoria, Australia
Huizhou, Guangdong, China
Los Angeles, California, United States
Koln, , Germany
Pamplona, , Spain
Encinitas, California, United States
Fresno, California, United States
Marietta, Georgia, United States
Merriam, Kansas, United States
Topeka, Kansas, United States
Wynnewood, Pennsylvania, United States
Caba, , Argentina
Caba, , Argentina
Caba, , Argentina
Caba, , Argentina
Caba, , Argentina
Caba, , Argentina
Cordoba, , Argentina
La Plata, , Argentina
Box Hill, Victoria, Australia
Melbourne, , Australia
St Poelten, , Austria
Vienna, , Austria
Wien, , Austria
Barretos, , Brazil
Botucatu, , Brazil
Brasilia, , Brazil
Campinas, , Brazil
Caxias Do Sul, , Brazil
Curitiba, , Brazil
Florianopolis, , Brazil
Jardim Das Americas, , Brazil
Porto Alegre, , Brazil
Recife, , Brazil
Recife, , Brazil
Ribeirao Preto, , Brazil
Rio De Janeiro, , Brazil
Rio De Janeiro, , Brazil
Salvador, , Brazil
Salvador, , Brazil
Sao Paulo, , Brazil
Sao Paulo, , Brazil
Sao Paulo, , Brazil
Sao Paulo, , Brazil
Sao Paulo, , Brazil
Sorocaba, , Brazil
Vitoria, , Brazil
Plovdiv, , Bulgaria
Sofia, , Bulgaria
Sofia, , Bulgaria
Varna, , Bulgaria
Greenfiled Park, Quebec, Canada
Montreal, Quebec, Canada
Montreal, Quebec, Canada
Quebec, , Canada
Foshan, Guangdong, China
Meizhou, Guangdong, China
Changde, Hunan, China
Nantong, Jiangsu, China
Nanchang, Jiangxi, China
Rizhao, Shandong, China
Dongyang, Zhejiang, China
Antony, , France
Montpellier Cedex, , France
Nice, , France
Saintcloud, , France
Strasbourg, , France
Vandoeuvrelesnancy, , France
Kutaisi, , Georgia
Tbilisi, , Georgia
Tbilisi, , Georgia
Magdeburg, , Germany
Wurzburg, , Germany
Athens, , Greece
Thessaloniki, , Greece
Dublin, , Ireland
Jerusalem, , Israel
Tel Aviv, , Israel
Aviano, , Italy
Bologna, , Italy
Pavia, , Italy
Ravenna, , Italy
Reggio Emilia, , Italy
Udine, , Italy
Busan, Busan Gwang'yeogsi, Korea, Republic Of
Busan, Busan Gwang'yeogsi, Korea, Republic Of
Susan, Busan Gwang'yeogsi, Korea, Republic Of
Seongnamsi, Gyeonggido, Korea, Republic Of
Seoul, Gyeonggido, Korea, Republic Of
Daegu, Gyeongsangbukdo, Korea, Republic Of
Jinjusi, Gyeongsangnamdo, Korea, Republic Of
Hwasungun, Jeonranamdo, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Seoul, Seoul Teugbyeolsi, Korea, Republic Of
Gorinchem, , Netherlands
Noord Brabant, , Netherlands
Bydgoszcz, , Poland
Katowice, , Poland
Poznan, , Poland
Skorzewo Poznan, , Poland
Warsaw, , Poland
Warszawa, , Poland
Almada, , Portugal
Vila Nova De Gaia Porto, , Portugal
Rio Piedras, , Puerto Rico
Bucharest, , Romania
Clujnapoca, , Romania
Craiova, , Romania
Iasi, , Romania
Oradea, , Romania
Durban, , South Africa
Kuils River, , South Africa
Pretoria, , South Africa
Pretoria, , South Africa
Pretoria, , South Africa
Hospitalet De Llobregat, , Spain
Madrid, , Spain
Terassa, , Spain
Fribourg, , Switzerland
La Chauxdefonds, , Switzerland
Ankara Oncology Abdurrahman Yurtaslan Hospital, , Turkey
Atakum Samsun, , Turkey
Golba Ankara, , Turkey
Istanbul, , Turkey
Istanbul, , Turkey
Mersin, , Turkey
Greater Manchester, , United Kingdom
Orange, New South Wales, Australia
Vancouver, British Columbia, Canada
Nanchang, Jiangxi, China
Sherbrooke, Quebec, Canada
Chibashi, Chiba, Japan
Hiroshimashi, Hiroshima, Japan
Yokohamashi, Kanagawa, Japan
Sendaishi, Miyagi, Japan
Kurashikishi, Okayama, Japan
Chuoku, Tokyo, Japan
Kyoto, , Japan
Kotoku, Tokyo, Japan
Beijing, Beijing, China
San Juan, , Puerto Rico
Busan, Busan Gwang'yeogsi, Korea, Republic Of
Ribeirao Preto, , Brazil
Sao Paulo, , Brazil
Sao Paulo, , Brazil
Porto Alegre, , Brazil
Jacksonville, Florida, United States
Porto Velho, , Brazil
Meizhou, Guangdong, China
Grand Island, Nebraska, United States
Oradea, , Romania
Sao Paulo, , Brazil
Columbia, Missouri, United States
Torun, , Poland
Dallas, Texas, United States
Tel Aviv, , Israel
Kutaisi, , Georgia
Vandoeuvrelesnancy, , France
Inverness, , United Kingdom
Grand Rapids, Michigan, United States
Almada, , Portugal
Vila Nova De Gaia Porto, , Portugal
Seongnamsi, Gyeonggi Do, Korea, Republic Of
Baltimore, Maryland, United States
Bronx, New York, United States
New Hyde Park, New York, United States
New York, New York, United States
Charlotte, North Carolina, United States
Longview, Texas, United States
Palestine, Texas, United States
Paris, Texas, United States
St Johns, Newfoundland And Labrador, Canada
Hwasungun, Jeollanam Do, Korea, Republic Of
Montreal Saintjerome, Quebec, Canada
Warsaw, , Poland
Ankara, , Turkey
North Adelaide, South Australia, Australia
Rio De Janeiro, , Brazil
Poznan, , Poland
Gazi University Medical School, , Turkey
San Diego, California, United States
Quebec, , Canada
Bayonne, New Jersey, United States
Chicoutimi, Quebec, Canada
Tbilisi, , Georgia
Nagoya, Aichi, Japan
Yokohamashi, , Japan
Matsuyamashi, Ehime, Japan
Pembroke Pines, Florida, United States
Wheeling, West Virginia, United States
Levis, Quebec, Canada
Neubrandenburg, , Germany
Catania, , Italy
Gdask, , Poland
Kielce, , Poland
Olsztyn, , Poland
Yamagatashi, Yamagata, Japan
Gdansk, , Poland
Kielce, , Poland
Olsztyn, , Poland
Houston, Texas, United States
Sapporoshi, Hokkaido, Japan
Sapporoshi, Hokkaido, Japan
Los Angeles, California, United States
Hattiesburg, Mississippi, United States
Westbury, New York, United States
Marietta, Georgia, United States
Omaha, Nebraska, United States
Spokane, Washington, United States
Nice, , France
Bundanggu Seongnamsi, Gyeonggi Do, Korea, Republic Of
Gangnamgu, Seoul Teugbyeolsi, Korea, Republic Of
Seochogu, Seoul Teugbyeolsi, Korea, Republic Of
Seodaemungu, Seoul Teugbyeolsi, Korea, Republic Of
Songpagu, Seoul Teugbyeolsi, Korea, Republic Of
Bethesda, Maryland, United States
Houston, Texas, United States
Sao Paulo, , Brazil
Vitoria, , Brazil
Montpellier, , France
Busanjingu, Busan Gwang'yeogsi, Korea, Republic Of
Seogu, , Korea, Republic Of
Balcova, , Turkey
Fresno, California, United States
Irvine, California, United States
Los Alamitos, California, United States
Los Angeles, California, United States
San Diego, California, United States
San Diego, California, United States
Pembroke Pines, Florida, United States
Pensacola, Florida, United States
Decatur, Illinois, United States
Waukee, Iowa, United States
Topeka, Kansas, United States
Lexington, Kentucky, United States
Shreveport, Louisiana, United States
Baltimore, Maryland, United States
Grand Rapids, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Columbia, Missouri, United States
Springfield, Missouri, United States
Bayonne, New Jersey, United States
Bronx, New York, United States
East Setauket, New York, United States
New Hyde Park, New York, United States
New York, New York, United States
Charlotte, North Carolina, United States
Cincinnati, Ohio, United States
Watertown, South Dakota, United States
Dallas, Texas, United States
Houston, Texas, United States
Longview, Texas, United States
Palestine, Texas, United States
Tyler, Texas, United States
Puyallup, Washington, United States
Ciudad Autonoma Buenos Aires, , Argentina
Malvern East, Victoria, Australia
St Polten, , Austria
Gand, , Belgium
Recife, , Brazil
Recife, , Brazil
Rio De Janeiro, , Brazil
Salvador, , Brazil
Saintjerome, Quebec, Canada
Hradec Kralove, , Czechia
Athens, , Greece
Tel Aviv Jaffa, , Israel
Tel Aviv Jaffa, , Israel
Kyotoshi, Kyoto, Japan
Bunkyoku, Tokyo, Japan
Seogu, Busan Gwang'yeogsi, Korea, Republic Of
Seongbukgu, Gyeonggi Do, Korea, Republic Of
Bukgu, Gyeongsangbukdo, Korea, Republic Of
Yongsangu, Seoul Teugbyeolsi, Korea, Republic Of
Warszawa, , Poland
Madrid, , Spain
Majadahonda, , Spain
Terrassa, , Spain
Aociftlii, , Turkey
Tevikiye, , Turkey
Seogu, Busan Gwang'yeogsi, Korea, Republic Of
Patients applied
Trial Officials
Study Director
Study Director
BeiGene
Study Director
Principal Investigator
BeiGene
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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