Theta-burst rTMS in Schizophrenia to Ameliorate Negative and Cognitive Symptoms

Launched by SEMMELWEIS UNIVERSITY · Oct 20, 2021

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Eligibility criteria

• Inclusion Criteria:
• • 1. diagnosis of schizophrenia or schizoaffective disorder;
• • 2. clinically stabilized on antipsychotic: a stable dose of antipsychotic medication for \>4 weeks;
• • 3. age 18-55 years, and
• • 4. presence of negative symptoms (based on PANSS): a negative subscore ≥16 points and \[one of items N1-N7 scoring ≥4 or two items N1-N7 scoring ≥3\]
• Exclusion Criteria:
• • 1. any significant neurological illness;
• • 2. mental retardation
• • 3. history of head injury with loss of consciousness for more than 1 hour
• • 4. history of epileptic seizures or epileptic activity on the baseline EEG (evaluated by an expert in clinical EEG and epilepsy),
• • 5. alcohol or drug abuse within the past 3 months, and
• • 6. depressive episode or antidepressant treatment in the past 4 weeks.
• • 7. Severe positive symptoms inferfere with cognitive tests
• • 8. ECT in the medical history
• • 9. Implanted pacemaker, implanted drug pump, cochlear implant, implanted defibrillator, implanted neurostimulator or any other TMS incompatible implanted metal device
• • 10. Skin surface is severly injured in the stimulated region of the skull
• • 11. Sclerosis multiplex
• • 12. Pregnancy
• • 13. Severe sleep deprivation
• • 14. Severe heart failure
• • 15. Increased intracranial pressure
• • 16. Untreated migrain