Nitric Oxide Effect on Brain and Kidney in Pediatric Patients Undergoing Cardiopulmonary Bypass

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Oct 29, 2021

Keywords

ClinConnect Summary

Corrective cardiac surgery for congenital heart disease (CHD) requiring cardiopulmonary bypass (CPB) is associated with numerous postoperative complications including neural tissue damage resulting in long-term neurocognitive deficits as well as acute kidney injury impacting renal function. Non-cardiac organ complications result in an increased mortality and length of hospital stay. Nitric oxide (NO) has been shown to play a protective role in a systemic inflammatory response, with administration of NO reducing damage to the liver, lungs, kidney, and brain in experimental models. Recent stu...

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Eligibility criteria

• Inclusion Criteria:
• • 1. Neonates and infants with CHD undergoing CPB for corrective surgery
• • 2. Age \<1 year old
• Exclusion Criteria:
• • 1. Requirement of inhaled NO immediately prior to surgery
• • 2. Emergency surgery
• • 3. Severe developmental delay at baseline defined as a score of ≥ 4 (severe disability) on the Pediatric Cerebral Performance Category (PCPC) Scale, referencing cognitive status prior to critical illness
• • 4. Pre-existing renal disease
• • 5. Inability to understand English or deafness that will preclude delirium evaluation. The inability to understand English in verbal participants will not result in exclusion when the research staff is proficient and/or translation services are actively available in that particular language.