NFC Changes in SLE Patients and Its Correlation With Anti-U1RNPAntibodies and Disease Activity
Launched by ASSIUT UNIVERSITY · Oct 25, 2021
Trial Information
Current as of July 09, 2025
Unknown status
Keywords
ClinConnect Summary
Systemic lupus erythematosus is a complex, multi-organ autoimmune disease . The presence of autoantibodies and circulating immune complexes can cause vasculitis and damage the endothelial cells, leading to multiple organ dysfunctions .The clinical manifestations of SLE include muco cutaneous, musculoskeletal system, cardiac, neurological, renal, hematologic, and vascular system involvement . Nail fold capillaroscopy (NFC) is a non-invasive easily repeatable technique and the best method for morphological analysis of nutritional capillaries in the nail fold area . Nail fold capillary changes...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Adult SLE Patients who fulfilled the 2012 systemic lupus international collaborating clinics (SLICC) criteria
- Exclusion Criteria:
- • 1. SLE patient aged less than 18 yeares old.
- • 2. Individuals with other autoimmune diseases (rheumatoid arthritis dermatomyositis, scleroderma, mixed connective tissue disease).
- • 3. Congestive cardic failure and presence of clupping.
- • 4. Coexisting diabetes mellitus.
- • 5. history of smoking.
- • 6. Patients unable to co-operate for nailfold capillaroscopic examination
About Assiut University
Assiut University, a prominent academic institution located in Egypt, is dedicated to advancing medical research and clinical trials that enhance healthcare outcomes. With a strong emphasis on innovation and collaboration, the university engages in a wide array of clinical studies across various disciplines, aiming to contribute valuable insights into disease prevention, diagnosis, and treatment. Assiut University's commitment to ethical research practices and rigorous scientific methodology ensures the integrity and reliability of its clinical trials, ultimately benefiting both the local community and the global medical landscape.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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