Aspiration in Acute Respiratory Failure Survivors 2

Launched by UNIVERSITY OF COLORADO, DENVER · Oct 25, 2021

Keywords

ClinConnect Summary

This clinical trial, called "Aspiration in Acute Respiratory Failure Survivors 2," is looking into swallowing problems that can occur in patients who have been very ill and needed a breathing machine for more than two days. The study aims to understand how these swallowing issues, known as dysphagia, can affect recovery after being in the intensive care unit (ICU).

To participate in the trial, patients must be admitted to the ICU and have been on a breathing machine (mechanical ventilation) for over 48 hours. Unfortunately, some patients won't be able to join, such as those with certain pre-existing conditions or those who have been off the machine for too long. If eligible, participants will undergo assessments to help researchers learn more about their swallowing abilities and how it impacts their recovery. This study is important because it can help improve care for patients recovering from serious illnesses.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Admission to an ICU.
• • 2. Mechanical ventilation with an endotracheal tube for greater than 48 hours.
• Exclusion Criteria:
• • 1. Likely persistent contraindications to enteral/oral nutrition administration.
• • 2. Pre-existing history of dysphagia or aspiration.
• • 3. Pre-existing or acute primary central or peripheral neuromuscular disorder.
• • 4. Presence of a chronic tracheostomy (present prior to ICU admission).
• • 5. Pre-existing head and neck cancer or surgery.
• • 6. Coagulopathy resulting in uncontrolled nasal or pharyngeal bleeding.
• • 7. Delirium for more than 96 hours after extubation as assessed by Confusion Assessment Method (CAM-ICU).
• • 8. Extubated for greater than 96 hours.
• • 9. Inability to obtain informed consent from patient or an appropriate surrogate.
• • 10. Age \< 18 years.