Esophagus-sparing Radiotherapy for Metastatic Spinal Cord Compression.

Launched by HERLEV HOSPITAL · Oct 25, 2021

Keywords

ClinConnect Summary

The ESO-SPARE trial is studying a new type of radiation therapy that aims to protect the esophagus while treating metastatic spinal cord compression (MSCC), a serious condition where cancer spreads to the spine and can cause significant problems. The goal is to see if this esophagus-sparing approach can reduce the side effects that patients report, particularly issues related to the esophagus, without making other side effects worse or affecting the ability to move around. Researchers will enroll 200 patients who have been diagnosed with specific types of cancer and are referred for radiation treatment in the neck or upper back areas.

Eligible participants are adults aged 18 and older who have confirmed cancer and need palliative radiation therapy to relieve symptoms from MSCC or related conditions. Over the course of the trial, participants will receive either the standard radiation treatment or the esophagus-sparing treatment. They will be asked to complete questionnaires about their symptoms, pain, and quality of life for a total of nine weeks. This will help researchers understand how well these treatments work and how they affect patients' daily lives. If you or a loved one are interested in this study, it's important to discuss it with your healthcare provider to see if you qualify.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Histology or cytology proven cancer
• • Referred for palliative radiotherapy of the cervical or thoracic vertebra for
• • epidural ingrowth
• • metastatic spinal cord compression
• • metastatic spinal nerve root compression
• • post-operative radiotherapy after decompressive surgery for spinal cord or nerve root compression
• • Ability to understand and the willingness to sign a written informed consent document
• • Referred for the following dose prescriptions 5 Gy x 5, 5 Gy x 4, 3 Gy x 10, 10 Gy x 1, 8 Gy x 1.
• • ≥ 18 years old.
• Exclusion Criteria:
• • - Referred for \> 10 fractions