The Impact of Resistance ExerciSe on Muscle Mass in GlioblaSToma Survivors

Launched by NOVA SCOTIA HEALTH AUTHORITY · Nov 1, 2021

Keywords

ClinConnect Summary

PROBLEM: Glioblastoma multiforme (GBM) is the most common brain malignancy accounting for approximately 48% of all brain tumors. GBMs are highly vascular and can cause vasogenic brain edema and mass effect, which can worsen the neurologic symptoms associated with the disease. Corticosteroids (i.e., Dexamethasone; DEX) are the treatment of choice to reduce vasogenic edema and intercranial pressure associated with GBM. However, the use of steroids comes at a cost. High dose steroid therapy and/or long-term use results in muscle myopathy (i.e., muscle weakness) in 10-60% of GBM patients, signi...

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Eligibility criteria

• Inclusion Criteria:
• • histologically confirmed diagnosis of either primary or secondary GBM
• • received any dose of DEX
• • Karnofsky Performance Status (KPS) \>70
• • English fluency
• • physician approval
• • willingness to travel to Halifax to participate.
• Exclusion Criteria:
• • unstable or symptomatic cardiac or pulmonary disease, injury or co-morbid disease that precludes ability to safely exercise
• • significant cognitive limitations
• • uncontrolled seizures associated with impaired awareness