Pathogen-microbiome Interaction During Helicobacter Pylori Infection

Launched by UNIVERSITY HOSPITAL FREIBURG · Nov 9, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how the bacteria Helicobacter pylori (H. pylori) affects the gut microbiome, which is the community of microorganisms living in our intestines. Researchers want to understand why some people experience severe health issues from H. pylori while others may have it without any problems, or even beneficial effects. They believe that changes in the gut microbiome can be measured through stool samples and may help predict which patients will be more affected by the infection.

To participate in this study, you must be at least 18 years old and able to provide written consent. Patients will be those who are undergoing tests for H. pylori, while healthy volunteers can also join if they are between 18 and 65 years old and have no current medical conditions or recent antibiotic use. Participants will provide stool, blood, and tissue samples, and they can expect to contribute to important research that may improve understanding of H. pylori infections and their effects on gut health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients: -
• • Male and female patients aged ≥ 18 years.
• • Specimens from patients undergoing tissue sampling, stool, and blood to rule out Helicobacter pylori infection
• • Written informed consent from patients.
• • Volunteer subjects: -
• • Male and female (non-pregnant) volunteers between the ages of 18-65 years.
• • Written informed consent from volunteers.
• • No acute medical conditions
• • No regular medication use, and no antibiotic use in the last 4 weeks.
• Exclusion Criteria:
• • Patients: -
• • Minor patients
• • Patients not capable of giving consent
• • Samples without sufficient residual material after standard diagnostic procedures
• • Samples from patients who have not given consent for testing
• • Volunteer subjects: -
• • Subjects not capable of giving consent
• • Subjects with acute illnesses
• • Subjects older than 65 or younger than 18 years of age.
• • Pregnant women