Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)
Launched by ABBVIE · Nov 8, 2021
Trial Information
Current as of July 23, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying a medication called ubrogepant to see how safe and effective it is for treating migraines in children and adolescents aged 6 to 17 years. Migraines can cause severe headaches, often accompanied by nausea and sensitivity to light and sound. Ubrogepant is already approved for adults, and this study aims to determine the right dosage and effectiveness for younger patients with a history of migraines.
To participate, children must have had migraines for at least six months, experiencing 1 to 14 migraine attacks each month. They also need to be able to take tablets and complete some questionnaires. Participants will visit a clinic regularly and may receive either ubrogepant or a placebo (which looks like the medication but has no active ingredients) to compare effects. The study will last up to six months, and participants can take additional doses if their headaches are still severe. This trial offers an opportunity to help improve migraine treatment for children and adolescents, but it may require more visits and monitoring than usual care.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • A history of migraine with or without aura consistent with a diagnosis according to the International Classification of Headache Disorders (ICHD-3) for at least 6 months.
- • By history, the participant's migraines typically last between 3 and 72 hours if untreated or treated unsuccessfully and migraine episodes are separated by at least 48 hours of headache pain freedom.
- • History of 1 to 14 migraine attacks per month with moderate to severe headache in each of the 2 months prior to screening (Visit 1).
- • Current or past use of at least 1 oral medication (over-the-counter medication or prescription medication) for the acute treatment of migraine.
- • For main study participants, treatment of a qualifying migraine with single-blind placebo during the screening period and completion of 2-hour headache pain assessment.
- • Weight is ≥ 20 kg (44 pounds) and \< 135 kg (298 pounds)
- • Per investigator judgment, participant is able to swallow or can learn to swallow study intervention.
- • The participant is able to understand and complete the study questionnaires and eDiary. Participants who need assistance with reading the assessments may be assisted by a parent or guardian.
- Exclusion Criteria:
- • Any clinically significant hematologic, endocrine, pulmonary, renal, hepatic, gastrointestinal, cardiovascular or neurologic disease.
- • In the opinion of the investigator, other confounding pain syndromes, confounding psychiatric conditions, or other significant neurological disorders other than migraine.
- • History of malignancy in the 5 years prior to Visit 1.
- • History of any prior gastrointestinal conditions (eg, diarrhea syndromes, inflammatory bowel disease) that may affect the absorption or metabolism of the study intervention.
- • Significant risk of self-harm, based on clinical interview and responses on the Columbia-Suicide Severity Rating Scale (C-SSRS), or of harm to others; participants must be excluded if they report suicidal ideation with intent, with or without a plan, (ie, Type 4 or 5 on the C-SSRS) in the past 6 months or report suicidal behavior in the last 6 months prior to Visit 1 or Visit 2 assessments.
- • At Visit 1, current alcohol or drug abuse or dependence per investigator's judgment.
- • For main study participants, no headache at the 2-hour post dose assessment after taking single-blind placebo for a qualifying migraine during screening period (ie, placebo responder).
- • A current diagnosis of chronic migraine as defined by ICHD-3
- • Participants who overuse medication for migraine defined as use of opioids or barbiturates \> 2 days/month, triptans or ergots ≥ 10 days/month, simple analgesics (eg, aspirin, NSAIDs, acetaminophen) ≥ 15 days/month or any combination of triptans, ergots, or simple analgesics (eg, aspirin, NSAIDs, acetaminophen) ≥ 10 days/month in the 3 months prior to Visit 1 per investigator's judgment.
- • Difficulty distinguishing migraine headache from tension-type or other headaches.
- • Has a history of migraine aura with diplopia or impairment of level of consciousness, hemiplegic migraine, or retinal migraine as defined by ICHD-3.
- • Has a current diagnosis of new persistent daily headache, trigeminal autonomic cephalgia (eg, cluster headache), or painful cranial neuropathy as defined by ICHD-3
- • Required in-hospital (excluding emergency department visits) treatment for migraines 3 or more times in the 6 months prior to Visit 1.
- • Requirement for any medication (eg, barbiturates) or diet (eg, grapefruit juice) that is on the list of prohibited concomitant medications that cannot be discontinued or switched to an allowable, alternative medication at Visit 1.
- • Previous exposure, within the last 6 months, to injectable monoclonal antibodies blocking the calcitonin gene-related peptide (CGRP) pathway
- • History of hypersensitivity or clinically significant adverse reaction to a CGRP receptor antagonist or hypersensitivity to any component of the study interventions, ubrogepant or placebo.
- • Currently participating or has participated in a study with an investigational compound or device within 30 days prior to Visit 1
About Abbvie
AbbVie is a global biopharmaceutical company dedicated to developing innovative therapies that address complex health challenges. Founded in 2013 as a spin-off from Abbott Laboratories, AbbVie focuses on key therapeutic areas, including immunology, oncology, neuroscience, and virology. The company is committed to advancing scientific research and delivering groundbreaking treatments that enhance patient outcomes and quality of life. With a robust pipeline and a strong emphasis on collaboration, AbbVie strives to transform the future of medicine through its commitment to clinical excellence and patient-centered approaches.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Huntsville, Alabama, United States
Saraland, Alabama, United States
Little Rock, Arkansas, United States
Little Rock, Arkansas, United States
Anaheim, California, United States
Fresno, California, United States
Lafayette, California, United States
Long Beach, California, United States
Los Angeles, California, United States
Oceanside, California, United States
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Aurora, Colorado, United States
Centennial, Colorado, United States
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Charlotte, North Carolina, United States
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Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
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Portland, Oregon, United States
Philadelphia, Pennsylvania, United States
Scottdale, Pennsylvania, United States
Smithfield, Pennsylvania, United States
Charleston, South Carolina, United States
Greenville, South Carolina, United States
Greer, South Carolina, United States
Memphis, Tennessee, United States
Nashville, Tennessee, United States
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Beaumont, Texas, United States
Cedar Park, Texas, United States
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Friendswood, Texas, United States
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Kerrville, Texas, United States
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Plano, Texas, United States
San Antonio, Texas, United States
The Woodlands, Texas, United States
Waxahachie, Texas, United States
Salt Lake City, Utah, United States
Salt Lake City, Utah, United States
Woodstock, Vermont, United States
Franklin, Virginia, United States
Norfolk, Virginia, United States
Richmond, Virginia, United States
Everett, Washington, United States
Kingwood, West Virginia, United States
Ames, Iowa, United States
Los Angeles, California, United States
Germantown, Tennessee, United States
Dorado, , Puerto Rico
San Juan, , Puerto Rico
Ponce, , Puerto Rico
Bountiful, Utah, United States
Mansfield, Texas, United States
Charleston, South Carolina, United States
Decatur, Georgia, United States
Miami, Florida, United States
Winter Park, Florida, United States
Chicago, Illinois, United States
Ridgeland, Mississippi, United States
Columbus, Ohio, United States
Aurora, Colorado, United States
Upland, California, United States
Tampa, Florida, United States
Salt Lake City, Utah, United States
Weston, Florida, United States
New York, New York, United States
Long Beach, California, United States
Fort Myers, Florida, United States
Austin, Texas, United States
San Juan, , Puerto Rico
San Juan, , Puerto Rico
Bayamon, , Puerto Rico
Hollywood, Florida, United States
Stamford, Connecticut, United States
Cincinnati, Ohio, United States
Walnut Creek, California, United States
Winter Park, Florida, United States
Austin, Texas, United States
San Diego, California, United States
Savannah, Georgia, United States
Ames, Iowa, United States
Amherst, New York, United States
Greer, South Carolina, United States
Orlando, Florida, United States
Miami, Florida, United States
Smithfield, Pennsylvania, United States
Mequon, Wisconsin, United States
Fresno, California, United States
Overland Park, Kansas, United States
Hot Springs, Arkansas, United States
Patients applied
Trial Officials
ABBVIE INC.
Study Director
AbbVie
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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