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Search / Trial NCT05125302

Study to Assess Adverse Events and Disease Activity of Oral Ubrogepant Tablets for the Acute Treatment of Migraine in Children and Adolescents (Ages 6-17)

Launched by ABBVIE · Nov 8, 2021

Trial Information

Current as of July 23, 2025

Recruiting

Keywords

Migraine Ubrogepant Ubrelvy Periscope

ClinConnect Summary

This clinical trial is studying a medication called ubrogepant to see how safe and effective it is for treating migraines in children and adolescents aged 6 to 17 years. Migraines can cause severe headaches, often accompanied by nausea and sensitivity to light and sound. Ubrogepant is already approved for adults, and this study aims to determine the right dosage and effectiveness for younger patients with a history of migraines.

To participate, children must have had migraines for at least six months, experiencing 1 to 14 migraine attacks each month. They also need to be able to take tablets and complete some questionnaires. Participants will visit a clinic regularly and may receive either ubrogepant or a placebo (which looks like the medication but has no active ingredients) to compare effects. The study will last up to six months, and participants can take additional doses if their headaches are still severe. This trial offers an opportunity to help improve migraine treatment for children and adolescents, but it may require more visits and monitoring than usual care.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • A history of migraine with or without aura consistent with a diagnosis according to the International Classification of Headache Disorders (ICHD-3) for at least 6 months.
  • By history, the participant's migraines typically last between 3 and 72 hours if untreated or treated unsuccessfully and migraine episodes are separated by at least 48 hours of headache pain freedom.
  • History of 1 to 14 migraine attacks per month with moderate to severe headache in each of the 2 months prior to screening (Visit 1).
  • Current or past use of at least 1 oral medication (over-the-counter medication or prescription medication) for the acute treatment of migraine.
  • For main study participants, treatment of a qualifying migraine with single-blind placebo during the screening period and completion of 2-hour headache pain assessment.
  • Weight is ≥ 20 kg (44 pounds) and \< 135 kg (298 pounds)
  • Per investigator judgment, participant is able to swallow or can learn to swallow study intervention.
  • The participant is able to understand and complete the study questionnaires and eDiary. Participants who need assistance with reading the assessments may be assisted by a parent or guardian.
  • Exclusion Criteria:
  • Any clinically significant hematologic, endocrine, pulmonary, renal, hepatic, gastrointestinal, cardiovascular or neurologic disease.
  • In the opinion of the investigator, other confounding pain syndromes, confounding psychiatric conditions, or other significant neurological disorders other than migraine.
  • History of malignancy in the 5 years prior to Visit 1.
  • History of any prior gastrointestinal conditions (eg, diarrhea syndromes, inflammatory bowel disease) that may affect the absorption or metabolism of the study intervention.
  • Significant risk of self-harm, based on clinical interview and responses on the Columbia-Suicide Severity Rating Scale (C-SSRS), or of harm to others; participants must be excluded if they report suicidal ideation with intent, with or without a plan, (ie, Type 4 or 5 on the C-SSRS) in the past 6 months or report suicidal behavior in the last 6 months prior to Visit 1 or Visit 2 assessments.
  • At Visit 1, current alcohol or drug abuse or dependence per investigator's judgment.
  • For main study participants, no headache at the 2-hour post dose assessment after taking single-blind placebo for a qualifying migraine during screening period (ie, placebo responder).
  • A current diagnosis of chronic migraine as defined by ICHD-3
  • Participants who overuse medication for migraine defined as use of opioids or barbiturates \> 2 days/month, triptans or ergots ≥ 10 days/month, simple analgesics (eg, aspirin, NSAIDs, acetaminophen) ≥ 15 days/month or any combination of triptans, ergots, or simple analgesics (eg, aspirin, NSAIDs, acetaminophen) ≥ 10 days/month in the 3 months prior to Visit 1 per investigator's judgment.
  • Difficulty distinguishing migraine headache from tension-type or other headaches.
  • Has a history of migraine aura with diplopia or impairment of level of consciousness, hemiplegic migraine, or retinal migraine as defined by ICHD-3.
  • Has a current diagnosis of new persistent daily headache, trigeminal autonomic cephalgia (eg, cluster headache), or painful cranial neuropathy as defined by ICHD-3
  • Required in-hospital (excluding emergency department visits) treatment for migraines 3 or more times in the 6 months prior to Visit 1.
  • Requirement for any medication (eg, barbiturates) or diet (eg, grapefruit juice) that is on the list of prohibited concomitant medications that cannot be discontinued or switched to an allowable, alternative medication at Visit 1.
  • Previous exposure, within the last 6 months, to injectable monoclonal antibodies blocking the calcitonin gene-related peptide (CGRP) pathway
  • History of hypersensitivity or clinically significant adverse reaction to a CGRP receptor antagonist or hypersensitivity to any component of the study interventions, ubrogepant or placebo.
  • Currently participating or has participated in a study with an investigational compound or device within 30 days prior to Visit 1

About Abbvie

AbbVie is a global biopharmaceutical company dedicated to developing innovative therapies that address complex health challenges. Founded in 2013 as a spin-off from Abbott Laboratories, AbbVie focuses on key therapeutic areas, including immunology, oncology, neuroscience, and virology. The company is committed to advancing scientific research and delivering groundbreaking treatments that enhance patient outcomes and quality of life. With a robust pipeline and a strong emphasis on collaboration, AbbVie strives to transform the future of medicine through its commitment to clinical excellence and patient-centered approaches.

Locations

Huntsville, Alabama, United States

Saraland, Alabama, United States

Little Rock, Arkansas, United States

Little Rock, Arkansas, United States

Anaheim, California, United States

Fresno, California, United States

Lafayette, California, United States

Long Beach, California, United States

Los Angeles, California, United States

Oceanside, California, United States

San Diego, California, United States

San Jose, California, United States

Upland, California, United States

Aurora, Colorado, United States

Centennial, Colorado, United States

Colorado Springs, Colorado, United States

Washington, District Of Columbia, United States

Boynton Beach, Florida, United States

Fort Myers, Florida, United States

Gainesville, Florida, United States

Gulf Breeze, Florida, United States

Hialeah, Florida, United States

Hollywood, Florida, United States

Homestead, Florida, United States

Lakeland, Florida, United States

Miami, Florida, United States

Miami, Florida, United States

Miami, Florida, United States

Orange City, Florida, United States

Palm Harbor, Florida, United States

Pembroke Pines, Florida, United States

Pembroke Pines, Florida, United States

Spring Hill, Florida, United States

Tampa, Florida, United States

Weston, Florida, United States

Winter Park, Florida, United States

Atlanta, Georgia, United States

Atlanta, Georgia, United States

Atlanta, Georgia, United States

Brunswick, Georgia, United States

Decatur, Georgia, United States

Savannah, Georgia, United States

Stockbridge, Georgia, United States

Meridian, Idaho, United States

Ames, Iowa, United States

Overland Park, Kansas, United States

Overland Park, Kansas, United States

Wichita, Kansas, United States

Lexington, Kentucky, United States

Baltimore, Maryland, United States

Bloomfield Hills, Michigan, United States

Burnsville, Minnesota, United States

Petal, Mississippi, United States

Ridgeland, Mississippi, United States

Ozark, Missouri, United States

Papillion, Nebraska, United States

Nashua, New Hampshire, United States

Annandale, New Jersey, United States

Morristown, New Jersey, United States

Runnemede, New Jersey, United States

Amherst, New York, United States

Mount Kisco, New York, United States

Port Jefferson Station, New York, United States

Syracuse, New York, United States

Charlotte, North Carolina, United States

Hickory, North Carolina, United States

Cincinnati, Ohio, United States

Cincinnati, Ohio, United States

Cincinnati, Ohio, United States

Cincinnati, Ohio, United States

Columbus, Ohio, United States

West Chester, Ohio, United States

Oklahoma City, Oklahoma, United States

Oklahoma City, Oklahoma, United States

Portland, Oregon, United States

Philadelphia, Pennsylvania, United States

Scottdale, Pennsylvania, United States

Smithfield, Pennsylvania, United States

Charleston, South Carolina, United States

Greenville, South Carolina, United States

Greer, South Carolina, United States

Memphis, Tennessee, United States

Nashville, Tennessee, United States

Austin, Texas, United States

Austin, Texas, United States

Beaumont, Texas, United States

Cedar Park, Texas, United States

Dallas, Texas, United States

Dallas, Texas, United States

El Paso, Texas, United States

Friendswood, Texas, United States

Houston, Texas, United States

Houston, Texas, United States

Kerrville, Texas, United States

Lampasas, Texas, United States

Plano, Texas, United States

San Antonio, Texas, United States

The Woodlands, Texas, United States

Waxahachie, Texas, United States

Salt Lake City, Utah, United States

Salt Lake City, Utah, United States

Woodstock, Vermont, United States

Franklin, Virginia, United States

Norfolk, Virginia, United States

Richmond, Virginia, United States

Everett, Washington, United States

Kingwood, West Virginia, United States

Ames, Iowa, United States

Los Angeles, California, United States

Germantown, Tennessee, United States

Dorado, , Puerto Rico

San Juan, , Puerto Rico

Ponce, , Puerto Rico

Bountiful, Utah, United States

Mansfield, Texas, United States

Charleston, South Carolina, United States

Decatur, Georgia, United States

Miami, Florida, United States

Winter Park, Florida, United States

Chicago, Illinois, United States

Ridgeland, Mississippi, United States

Columbus, Ohio, United States

Aurora, Colorado, United States

Upland, California, United States

Tampa, Florida, United States

Salt Lake City, Utah, United States

Weston, Florida, United States

New York, New York, United States

Long Beach, California, United States

Fort Myers, Florida, United States

Austin, Texas, United States

San Juan, , Puerto Rico

San Juan, , Puerto Rico

Bayamon, , Puerto Rico

Hollywood, Florida, United States

Stamford, Connecticut, United States

Cincinnati, Ohio, United States

Walnut Creek, California, United States

Winter Park, Florida, United States

Austin, Texas, United States

San Diego, California, United States

Savannah, Georgia, United States

Ames, Iowa, United States

Amherst, New York, United States

Greer, South Carolina, United States

Orlando, Florida, United States

Miami, Florida, United States

Smithfield, Pennsylvania, United States

Mequon, Wisconsin, United States

Fresno, California, United States

Overland Park, Kansas, United States

Hot Springs, Arkansas, United States

Patients applied

0 patients applied

Trial Officials

ABBVIE INC.

Study Director

AbbVie

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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