Clinical Experience of Thalidomide in Thalassemic Patients
Launched by CHILDREN'S HOSPITAL KARACHI · Nov 11, 2021
Trial Information
Current as of October 18, 2025
Completed
Keywords
ClinConnect Summary
The purpose of the study was to evaluate the efficacy and safety of the combination therapy of hydroxyurea and thalidomide in beta-thalassemia patients. The participants were evaluated on the basis of eligibility criteria, consent was obtained and baseline investigations were performed on the screening visit. Participants were continued on Hydroxyurea (10-20mg/kg/day) for the first six months and then for the next six months thalidomide (2-5 mg/kg/day) was added to the intervention. Aspirin was also added (2-4mg/kg/day).
Efficacy:
Maintenance or rise in Hemoglobin (Hb) levels and changes ...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Patients with clinical and genetic diagnosis of β-thalassemia major and intermedia
- • 2. Patients who showed partial response or a decline in response to hydroxyurea
- • 3. Patients who are not the candidates for the bone marrow transplant procedure.
- Exclusion Criteria:
- • 1. Married Patients
- • 2. Patients with comorbidities such as liver, cerebrovascular, cardiovascular, or kidney diseases
- • 3. Patients allergic to the drug ingredients
- • 4. Patients with mental disorders
- • 5. Patients who are enrolled in other clinical trials
- • 6. Patients with a history of venous or arterial thrombosis
About Children's Hospital Karachi
Children's Hospital Karachi is a leading pediatric healthcare institution dedicated to providing comprehensive medical services to children. As a prominent clinical trial sponsor, the hospital is committed to advancing pediatric medicine through innovative research and collaborative studies. With a focus on improving health outcomes for children, the institution adheres to rigorous ethical standards and regulatory guidelines, ensuring the safety and well-being of its young patients. The hospital's multidisciplinary team of experts works collaboratively to design and conduct clinical trials that address critical health issues, contributing to the global body of knowledge in child health and treatment.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Karachi, Sindh, Pakistan
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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