Treating Early Stage Diabetic Retinopathy
Launched by VA OFFICE OF RESEARCH AND DEVELOPMENT · Nov 22, 2021
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Diabetic Retinopathy (DR) is a leading cause of vision loss in the US. To detect DR, individuals with diabetes are instructed to receive annual eye exams until visible retinopathy such as hemorrhages or aneurysms appear that often take years to develop. Even so, treatment is only provided when visually threatening disease is detected. The investigators' group and others have established that in people with diabetes, retinal neuronal dysfunction precedes clinically visible retinopathy. Non-invasive recordings of retinal function using the electroretinogram (ERG) have shown dysfunction with d...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • HbA1c 8-12%
- • Diabetic patients with no retinopathy as screened with teleretinal imaging
- • Diabetic patients with microaneurysms as detected with fundus teleretinal screening
- • ERG oscillatory potential delays in response to dim flash stimuli
- Exclusion Criteria:
- • Patients with pituitary tumor, psychosis, Parkinson's disease
- • Patients with confounding ocular disease (visually significant cataract, glaucoma, macular degeneration, retinitis pigmentosa)
- • Patients with cognitive deficits (score of 24 or less on the Montreal Cognitive
- • Assessment-MOCA
- • No anti-VEGF or steroid treatments within the last 12 months
- • Pregnancy
About Va Office Of Research And Development
The VA Office of Research and Development (ORD) is dedicated to advancing the health and well-being of veterans through innovative research initiatives. As a pivotal sponsor of clinical trials, ORD focuses on a broad spectrum of health-related topics, including mental health, rehabilitation, and chronic disease management, ensuring that findings are directly applicable to the unique needs of the veteran population. With a commitment to scientific excellence and collaboration, ORD promotes rigorous study designs and ethical standards, facilitating the translation of research discoveries into improved clinical practices and policies that enhance veteran care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Decatur, Georgia, United States
Decatur, Georgia, United States
Patients applied
Trial Officials
Machelle T. Pardue, PhD
Principal Investigator
Atlanta VA Medical and Rehab Center, Decatur, GA
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials