High Resolution Manometry After Partial Fundoplication for Gastro-oesophageal Reflux

Launched by PROF URS ZINGG · Nov 12, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how well the esophagus works after a specific type of surgery called partial fundoplication, which is commonly done to treat gastroesophageal reflux disease (GERD). The researchers want to find out if patients who have trouble swallowing due to weak contractions in their esophagus (a condition known as ineffective esophageal motility) can see improvements in their swallowing ability after this surgery. They will compare how the esophagus functions before and after the operation to see if there are positive changes.

To participate in this study, you need to be over 18 years old and have been diagnosed with ineffective esophageal motility based on specific criteria. If you are eligible and agree to take part, you will be contacted about 1-2 years after your surgery and invited to the study site for a test called high-resolution manometry, which measures how well your esophagus is working. The study aims to help improve understanding of how GERD affects esophageal function and how surgery can help patients feel better.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age older than 18 years
• • Ineffective esophageal motility disorder according the Chicago classification (7), defined as ≥ 7/10 (70%) of swallows with weak contraction (distal contraction interval (DCI) between 100mmHg/s/cm and less than 450 mmHg/s/cm) or ≥ 5/10 (50%) of swallows with failed peristalsis (DCI \<100mgHg/s/cm)Performance of partial fundoplication (180° anterior or 270° posterior) at Spital Limmattal
• • Informed Consent as documented by signature
• Exclusion Criteria:
• • Age under 18 years
• • Pregnancy
• • Normal preoperative esophageal motility
• • Other specifically defined esophageal motility disorders such as Nutcracker or Jackhammer esophagus
• • Preoperative presence of a hiatal hernia with migration of \>20% of stomach in the chest
• • Revisional surgery (after other procedures for reflux or at the hiatus)