RAdiolabeled Perfusion to Identify Coronary Artery Disease Using WAter To Evaluate Responses of Myocardial FLOW (RAPID-WATER-FLOW)

Launched by MEDTRACE PHARMA A/S · Nov 15, 2021

Keywords

ClinConnect Summary

The RAPID-WATER-FLOW clinical trial is studying a new method to help identify coronary artery disease (CAD) using a special imaging technique called PET (Positron Emission Tomography). This study will include around 215 participants aged 18 and older who are suspected of having CAD and have been referred for tests. To qualify, participants should have undergone certain heart tests within the last 30 days, and women of childbearing potential must have a negative pregnancy test.

If you join this trial, you will receive two injections of a radioactive water substance called \[15-O\]-H2O during a single imaging session—one while resting and another while experiencing drug-induced stress. The study aims to evaluate how well this method shows blood flow in the heart, which can indicate the presence of CAD. After the imaging session, you'll receive a follow-up phone call to check on your safety. This trial is currently recruiting participants across several sites in the United States and Europe.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male and female participants ≥18 years;
• • 2. Informed consent form (ICF) read, signed, and dated prior to any study procedures being performed;
• 3. Participants who fall into any one of the following categories:
• • 1. Have been referred for an ICA directly of after non-invasive testing (e.g., SPECT or PET MPI, stress echo, CCTA, ETT).
• • 2. Had an ICA with no intervention. However, if any stenosis \>40% but ≤70% was observed, an FFR or iFR assessment was performed.
• • 3. Had a CCTA with normal coronaries or minimal CAD (no stenosis \>25%).
• • The SPECT study, PET 15O-H2O study, and ICA or CCTA testing need to be completed within a 30-day window, with time 0 defined as the date of the first of these three tests.
• • 4. Women of Child Bearing Potential (WOCBP) must be non-pregnant, and non-lactating. For women of childbearing potential, the results of a urine human chorionic gonadotropin (HCG) pregnancy test (with the result known on the day of drug administration) must be negative; these participants must be practicing appropriate birth control from time of the screening visit until the end of the follow-up period. For women who are either surgically sterile (have a documented bilateral tubal ligation or oophorectomy and/or hysterectomy) or are post-menopausal (cessation of menses for more than 1 year), enrollment in the study without a pregnancy test at screening is allowed.
• • 5. Male will need to use contraceptive methods until end of the follow-up period.
• • 6. Participants are able to comply with all study procedures as described in the protocol.
• Exclusion Criteria:
• • 1. Participants are unable to undergo (even partially) any of the imaging procedures;
• 2. Participants with a known history of cardiac disease including:
• • 1. myocardial infarction, previous coronary revascularization, or chronic ischemic cardiomyopathy
• • 2. primary myocardial disease such as cardiac amyloidosis or hypertrophic cardiomyopathy
• • 3. known left ventricular dysfunction
• • 4. moderate or severe aortic or mitral stenosis or regurgitation
• 3. Participants in whom adenosine stress testing is contraindicated, including but not limited to:
• • 1. Participants with severe COPD or chronic asthma.
• • 2. Participants with second- or third-degree atrioventricular block without a pacemaker.
• • 4. Participants with claustrophobia to an extent that would limit their ability to undergo SPECT and PET imaging (patients whose claustrophobia is known to be readily controlled with drugs or psychological support may be enrolled).
• • 5. Participants who are on sildenafil (Viagra) or oral dipyridamole (Persantine, Aggrenox) therapy or on any PDE5 inhibitor (i.e. tadalafil, avanafil, vardenafil),and for whom its use cannot be terminated or suspended for ≥24 hours prior to treatment of study drug.
• • 6. Participants with significant co-morbidities that would prevent appropriate completion of the protocol procedures.
• • 7. Participants who have participated in another research study using investigational drugs within the 30 days prior to enrollment or through the duration of the trial (patients in observational studies with approved agents and participants known to be on placebo may be enrolled).
• • 8. Participants who have previously participated in this study.
• • 9. Subjects scheduled for, or planning to undergo, any interventional cardiac procedures between enrollment and ICA (pathway 1) or signing of informed consent and 15O-H2O PET MPI (pathway 2 and 3)