Inflammatory Marker and Pre-existing Venous Fibrosis to Predict AVF Mal-maturation

Launched by NATIONAL TAIWAN UNIVERSITY HOSPITAL · Nov 23, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how certain factors, like inflammation and existing scarring in blood vessels, can affect the success of a procedure called an arteriovenous fistula (AVF). An AVF is a connection made between a vein and an artery in the arm, which is essential for patients with end-stage kidney disease to receive hemodialysis, a treatment that helps filter waste from the blood. Unfortunately, many AVFs do not mature properly, meaning they don't work as needed for dialysis. The trial will look at whether keeping or removing the fat around the vein during surgery makes a difference in how well the AVF matures.

Eligible participants for this study are adults aged 20 and older who require hemodialysis and have suitable blood vessels in their arms for the AVF procedure. The study will enroll about 100 patients, and they will be randomly assigned to one of two groups: one group will have the fat preserved during surgery, while the other group will have it removed. Throughout the study, participants will undergo assessments to see how well their AVF develops over time. If you're considering joining this trial, you'll receive detailed information and support to help you understand the process and what to expect.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Age of 20 and older adult patients.
• • 2. preoperatively clinical and ultrasound assessment of the arm vessels are visible for the creation of a native HDAVF that include：the augmented diameters of the veins is \> 2.0 mm and the diameter of the radial artery is\> 2.0 mm. Besides, there is no obvious stenosis of vessels in the forearm.
• Exclusion Criteria:
• • 1. The patient refused to join the study
• • 2. serious heart failure (Physicians identify insufficient cardiac output that may affect sacral blood flow development after surgery)
• • 3. Unconsciousness
• • 4. Bedridden for long time
• • 5. systemic lupus erythematosus(SLE), or other known autoimmune diseases
• • 6. The physician excludes the possibility of creating a wrist HDAVF before surgery
• • 7. Surgeon preoperatively identifies vessel inadequacy for the creation of a wrist HDAVF
• • 8. Choose a site other than the wrist for surgery
• • 9. Unexpected complications happen during the surgery that prevent the completion of a wrist HDAVF