The ORCHESTRATE-Myocarditis Registry

Launched by KANSAS CITY HEART RHYTHM RESEARCH FOUNDATION · Nov 17, 2021

Keywords

ClinConnect Summary

The ORCHESTRATE-Myocarditis Registry is a clinical trial that aims to study patients who experience chest pain but do not have any signs of heart disease after thorough testing. The researchers want to understand more about these patients, especially those who may have myocarditis, a condition where the heart muscle becomes inflamed. To be eligible for this trial, participants must be over 18 years old and have had chest pain that is either typical or unusual. Importantly, their tests must show no significant issues with their heart, meaning they should not have any signs of serious heart disease.

This study is currently not recruiting participants, but if it does in the future, those who qualify will be closely monitored to gather valuable information about their condition. It’s important to note that individuals with certain heart-related histories, like previous heart attacks or specific heart conditions, will not be able to participate. This trial could help improve understanding of unexplained chest pain and lead to better care for patients in the future.

Gender

ALL

Eligibility criteria

• • Inclusion criteria
• • 1. Age \>18 years
• • 2. Patients with a presentation of typical or atypical chest pain (ICD-10 Code R07.89, R07. 9)
• • 3. Patients with a negative ischemic workup: (including Coronary Artery Calcium Scoring/CTA, MPI, Nuclear Stress test, LHC/angiography showing anything greater than "non-obstructive CAD")
• • Exclusion criteria
• • 1. Patients with any evidence of positive ischemic workup as the cause of typical/atypical chest pain (as seen on Coronary Artery Calcium Scoring/CTA, MPI, Nuclear Stress test, LHC/angiography)
• • 2. Previously documented history of Prinzmetal angina or coronary vasospasm
• • 3. History of prior myocardial infarction
• • 4. History of any prior CAD with severity greater than "non-obstructive CAD" in all 3 coronary arteries
• • 5. History of LVEF\<40%
• • 6. Previously documented history of pericarditis
• • 7. Previously documented history of costochondritis