Comparing Intra-articular Betamethasone (Diprospan) and Triamcinolone Acetonide Injection in Knee Osteoarthritis
Launched by THAMMASAT UNIVERSITY · Nov 18, 2021
Trial Information
Current as of July 22, 2025
Completed
Keywords
ClinConnect Summary
After being informed about the study and potential risks, all patients giving written informed consent will be chosen for eligibility for the study entry. At day 0 (before intra-articular injection), patients who meet the eligibility criteria will be randomized in a double-blind manner (participant and investigator) in a 1:1 ratio to Betamethasone (Diprospan 1 ml) or Triamcinolone acetonide (40 mg) single intra-articular injection
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. Symptomatic Primary knee osteoarthritis (Kellgren-Lawrence stage 2 or 3)
- • 2. Failed other conservative treatment
- • 3. Comply with protocol
- Exclusion Criteria:
- • 1. Allergy to any of the medications in this protocol (Betamethasone, Triamcinolone, Paracetamol, Tramadol)
- • 2. Previous fracture or surgical procedure
- • 3. Previous intra-articular injection in the past 6 months
- • 4. Previous oral Symptomatic slow-acting drugs for osteoarthritis (SYSADOA) (Glucosamine, Diacerein) used in the past 6 months
- • 5. Current infection in the affected limb
- • 6. Uncontrolled Diabetes Mellitus
- • 7. Primary or secondary adrenal insufficiency
- • 8. Coagulopathy or current anticoagulant used
- • 9. Current steroid used
- • 10. Lower extremity weakness
About Thammasat University
Thammasat University, a leading academic institution in Thailand, is dedicated to advancing medical research and education through its various faculties and research centers. With a commitment to fostering innovative healthcare solutions, the university sponsors clinical trials aimed at enhancing patient outcomes and addressing pressing health challenges. Leveraging a multidisciplinary approach, Thammasat University collaborates with healthcare professionals and researchers to ensure rigorous scientific methodologies and ethical standards are upheld in all its clinical research endeavors. Through these initiatives, the university seeks to contribute significantly to the global body of medical knowledge and improve public health.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Khlong Luang, Pathumthani, Thailand
Patients applied
Trial Officials
KITTIPONG WATTANASIRISOMBAT, MD
Study Director
Thammasat University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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