Functional Magnetic Resonance Imaging in Patients With Obstructive Sleep Apnea Syndrome

Launched by CHU DE REIMS · Nov 29, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how the brain reacts in patients with obstructive sleep apnea syndrome (OSAS) while they are awake. OSAS is a condition where the upper airway collapses during sleep, causing breathing difficulties. Researchers want to see if patients with severe OSAS show similar brain activity as healthy individuals when their breathing is challenged, and whether this affects their thinking and awareness.

To participate in the study, you must be between 27 and 75 years old and have severe OSAS, which means you experience more than 30 breathing interruptions per hour during sleep. Participants should not be using CPAP treatment, a common therapy for sleep apnea. People without sleep apnea can also join as a comparison group, but they need to have fewer than 15 interruptions per hour and not feel excessively sleepy during the day. If you decide to participate, you will undergo brain scans while awake, and researchers will analyze how your brain responds to breathing challenges. It’s important to note that certain health conditions, medications, or pregnancy may prevent someone from being eligible for this study.

Gender

ALL

Eligibility criteria

• Inclusion criteria :
• • 1. OSAS patients
• • severe OSAS with an Apnea-Hypopnea Index (AHI) \> 30/h
• • without CPAP treatment
• • 2. Non-OSAS patients
• • absence of OSAS (AHI \< 15/h and absence of excessive daytime sleepiness with Epworth score \<11)
• Non-inclusion criteria :
• • \< 18 years old
• • \>75 years old
• • left-handed
• • BMI\> 40 kg/m²
• • another sleep disorder
• • central component of sleep apnea syndrome (central apnea index\> 5 / h)
• • current or past neurological pathology
• • respiratory pathology (obstructive ventilatory disorder, restrictive ventilatory disorder, hypercapnia)
• • MRI contraindication (metallic foreign body, claustrophobia, pregnant woman, etc.)
• • taking drugs that can modify the BOLD signal on MRI (psychotropic drugs, vasodilators, vasoconstrictors, etc.),
• • uncorrected sensory impairment (vision or hearing)
• • protected by law.
• Exclusion criteria :
• • pregnant woman according to the positive beta-hCG test result
• • left-handed following the laterality questionnaire
• * MINI results showing:
• • a current mood episode
• • a current disorder of the use of psychoactive substances or in the last 6 months (excluding tobacco)
• • an eating disorder
• • a diagnosis of bipolar disorder, current or past schizophrenia