Impact of Dietary Phosphate Excess on Exercise Capacity and Visceral Adiposity

Launched by UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER · Nov 23, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how eating too much phosphate, a mineral found in many foods, might affect our ability to exercise and our body fat, especially around the belly. Previous research in mice showed that when they consumed high levels of phosphate, they became less active, had a harder time exercising, and had lower metabolism rates. This trial aims to find out if these effects are also seen in healthy adults.

To participate in this study, you need to be between 18 and 74 years old and in good health, meaning you shouldn’t have diabetes, kidney disease, or heart problems. If you're interested, you’ll be involved in a randomized crossover trial, which means that you may receive different treatments at different times during the study. Participants can expect to learn more about how their diet might impact their physical activity and overall health. It’s important to note that certain health conditions and medications may disqualify you from joining the trial, so be sure to discuss your health history with the research team.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • The randomized crossover trial will be performed in on otherwise healthy subjects without diabetes mellitus, chronic kidney disease (CKD), preexisting cardiovascular disease or treatment with any vasoactive agent that might alter cardiovascular responses to exercise.
• Exclusion Criteria:
• • 1. history of cardiopulmonary disease or chronic kidney disease,
• • 2. treatment with antihypertensive medications,
• • 3. estimated glomerular filtration rate (eGFR) \< 60 mL/min/1.73m2, (4) diabetes mellitus or other systemic illness,
• • (5) pregnancy, (6) hypersensitivity to sodium phosphate, (7) any history of substance abuse or current cigarette use, (8) any history of psychiatric illness, (9) history of active malignancy, (10) serum phosphorus \< 2.4 or \> 4.5 mg/dL.