Deep Brain Stimulation in Laryngeal Dystonia and Voice Tremor

Launched by MASSACHUSETTS EYE AND EAR INFIRMARY · Nov 27, 2021

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a treatment called deep brain stimulation (DBS) on patients with voice disorders linked to conditions like laryngeal dystonia and essential tremor. Researchers want to find out how common these voice problems are in patients who are already getting DBS for their movement disorders. They will also look at brain imaging and electrical activity in the brain to understand why these voice issues happen and how DBS might help improve voice function.

To participate in this trial, you need to be between 18 and 80 years old and have a confirmed diagnosis of essential tremor or dystonia that hasn't responded well to other treatments. You also need to be able to follow instructions and complete some training before the surgery. If you decide to join, you will undergo evaluations to see if you qualify, and if you do, you’ll receive DBS and be monitored for changes in your voice. This trial is currently recruiting participants, and it's a chance to contribute to understanding how to better support individuals with voice problems related to these conditions.

Gender

ALL

Eligibility criteria

• • Inclusion
• • 1. Clinical indications to proceed with DBS implantation, as determined by the clinical multidisciplinary movement disorders board, including: a) definitive diagnosis of essential tremor or dystonia, b) medically refractory disease, c) adequate performance on neuropsychological evaluation as determined by a licensed clinical neuropsychologist.
• • 2. The ability to comply with test directions, complete pre-operative task training, and provide informed consent.
• • 3. Age 18-80 years.
• • Exclusion
• • 1. Inability to understand or perform the task outlined in the protocol during a pre-surgery training session. 2. Significant hearing loss.
• • 3. Cortical venous anatomy that could potentially obstruct ECoG electrode placement, as determined by the surgeon, visualized on pre-op MRI or during surgery.