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Search / Trial NCT05150483

EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure

Launched by EVANGELISMOS HOSPITAL · Dec 3, 2021

Trial Information

Current as of June 26, 2025

Recruiting

Keywords

Critical Illness Intensive Care Unit Endotypes Phenotypes Emergency Department Trajectory Mechanical Ventilation

ClinConnect Summary

This clinical trial is studying patients who come to the emergency department with a serious condition called acute hypoxemic respiratory failure, which means they are having trouble getting enough oxygen into their lungs. The researchers want to learn more about the different types of this condition and what factors—like clinical signs, imaging results, and biological markers—can help predict how likely a patient is to recover or experience ongoing severe breathing problems. They hope to gather important information that could improve care for future patients.

To join this study, participants must be adults over 18 years old who are experiencing new episodes of acute hypoxemic respiratory failure and need a significant amount of oxygen to maintain their oxygen levels. Unfortunately, people under 18, those in the hospital for comfort care only, or those with certain other types of respiratory failure will not be eligible. If someone participates, they can expect to have various health information collected early on, which may help doctors understand their condition better. The trial is currently recruiting participants, and all genders are welcome to take part.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Adult patients (aged \>18 years) presenting in the emergency department
  • De novo acute hypoxemic respiratory failure (requiring oxygen flow rate of 5 liters per minute or more to maintain SpO2 of 90% or more)
  • Exclusion Criteria:
  • Age \<18 years
  • Not admitted to the hospital
  • Postoperative acute respiratory failure (within one week from surgery)
  • Chronic hypoxemic respiratory failure (requiring long term oxygen therapy at home)
  • Hypercapnic respiratory failure
  • Transferred from another hospital or facility
  • Pregnant women
  • Admitted to the hospital purely to facilitate comfort care
  • Lack of informed consent

About Evangelismos Hospital

Evangelismos Hospital is a leading healthcare institution dedicated to advancing medical research and clinical trials. With a commitment to excellence in patient care and innovative therapies, the hospital leverages its state-of-the-art facilities and a multidisciplinary team of experienced professionals to conduct rigorous clinical studies. Evangelismos Hospital aims to contribute to the scientific community by facilitating the development of new treatments and improving health outcomes, while prioritizing patient safety and ethical standards throughout the research process.

Locations

Athens, Attiki, Greece

Patients applied

0 patients applied

Trial Officials

Ilias I. Siempos, MD, DSc

Principal Investigator

Evangelismos Hospital

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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