Genetic Susceptibility to Periprosthetic Joint Infections

Launched by UNIVERSITY OF UTAH · Dec 2, 2021

Keywords

ClinConnect Summary

This study is looking at genetics to understand why some people who have hip or knee replacement (total joint arthroplasty) develop an infection around the new joint, called a periprosthetic joint infection (PJI). It’s an observational, family-focused study, meaning researchers will follow families with a higher-than-normal chance of PJI to see if certain genes or genetic patterns are linked to the risk. Participants will provide DNA samples (blood or saliva) so scientists can look for genetic factors that might influence infection risk. The goal is to someday use this information to help prevent PJI in high-risk people.

Who can join: adults aged 18–100, both men and women, who are part of families with a higher risk of PJI after joint replacement (including unaffected relatives up to a third degree). The study will enroll about 150 people and is conducted by the University of Utah. Participation involves a genetic sample (blood draw or saliva/cheek cell) and no treatment is given as part of the study. Enrollment is by invitation, the study is ongoing with an estimated completion around 2028, and results will be used to improve understanding of genetic factors in PJI for future care. If you’re interested or have questions, the study team can be contacted through the listed investigators at the University of Utah.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Families/pedigrees which demonstrate a high-risk for PJI
• • Unaffected family members, up to 3rd degree
• Exclusion Criteria:
• • None