Treatment of Allergic Rhinitis and Chronic Polypous Rhinosinusitis With Olfactory Mucosa-derived Mesenchymal Stem Cells

Launched by INSTITUTE OF BIOPHYSICS AND CELL ENGINEERING OF NATIONAL ACADEMY OF SCIENCES OF BELARUS · Dec 9, 2021

Keywords

ClinConnect Summary

During the implementation of the project, the methods for the treatment of allergic rhinitis and chronic polypous rhinosinusitis with olfactory mucosa-derived mesenchymal stem cells will be developed.

The positive outlook for the effectiveness of MSCs is due to the following:

* knowledge of the leading role of immunopathogenetic mechanisms in the development of allergic rhinitis and chronic polypous rhinosinusitis and the pronounced immunomodulating properties of MSCs;
* the ability of MSCs to reduce the production of proinflammatory cytokines and suppress immune inflammation;
* positive ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Clinical diagnosis of allergic rhinitis or chronic polyposis rhinosinusitis
• • The patient can read, understand, follow the examination procedures and complete, if necessary, the required documentation
• • Written informed consent
• Exclusion Criteria:
• • The presence of any malignant tumor within the last 5 years
• • Acute or chronic diseases in the stage of decompensation
• • Chronic infectious diseases: HIV, viral hepatitis B, C, tuberculosis
• • Patients who are pregnant, breastfeeding, or fertile patients who are not using adequate contraceptive methods
• • Chronic and protracted mental disorders, all diseases with the presence of the syndrome of dependence on alcohol, drugs and psychoactive substances, any other condition that makes the patient unable to understand the nature, extent and possible consequences of the study or, in the opinion of the researcher, prevents the patient from observing and performing protocol
• • Patients are unable or unwilling to give written informed consent and / or follow research procedures
• • Any other medical condition that, in the opinion of the investigator, may be associated with an increased risk to the patient or may affect the outcome or evaluation of the study