Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients

Launched by BEIJING TIANTAN HOSPITAL · Dec 13, 2021

Keywords

ClinConnect Summary

This clinical trial is studying whether a medication called dexmedetomidine can help prevent postoperative delirium (POD) in elderly patients who are undergoing a specific type of brain surgery known as craniotomy. Postoperative delirium is a common issue after surgery, particularly in older adults, and can cause confusion and agitation. The researchers want to see if giving dexmedetomidine during the surgery can lower the chances of developing this condition.

To participate in the trial, patients need to be at least 65 years old and scheduled for a selective craniotomy. They must also be able to provide written consent to join the study. However, certain people are not eligible, such as those with cognitive impairments, severe heart or liver issues, or a history of specific medical conditions and medications. If someone is eligible and chooses to participate, they can expect to receive dexmedetomidine during their surgery and be monitored afterwards to see if it helps reduce the risk of delirium. This study aims to improve the care and outcomes for elderly patients undergoing brain surgery.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients undergoing selective craniotomy.
• • Age ≥65 years.
• • Obtain written informed consent.
• Exclusion Criteria:
• • Operation time less than 2 hours.
• • Refusal to provide written informed consent.
• • Cognitive impairment before surgery(mini-mental state examination, MMSE ≤ 26 or Montreal Cognitive Assessment, MoCA≤22).
• • Allergic to the study drug.
• • Body mass index ≤18 or ≥ 30 kg/m2.
• • History of psychotropic drugs, anticholinergic drugs, antihistamine drug and dopaminergic drugs.
• • History of traumatic brain injury or neurosurgery.
• • Severe bradycardia (heart rate less than 40 beats per minute), sick sinus syndrome or second-to-third degree atrioventricular block.
• • Severe liver dysfunction (Child-Pugh grade C) or renal failure (requiring kidney replacement therapy).
• • The functional neurosurgery.