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Search / Trial NCT05171478

Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

Launched by JOHNS HOPKINS UNIVERSITY · Dec 10, 2021

Trial Information

Current as of July 24, 2025

Recruiting

Keywords

Lung Cancer

ClinConnect Summary

This clinical trial is exploring a new way to examine small tissue samples taken from the lungs during a procedure called bronchoscopy, which doctors use to look inside the lungs and take biopsies (small samples of tissue). The trial aims to compare a special imaging technique called full-field optical coherence tomography (FFOCT) with the standard method of examining these biopsy samples under a microscope. This research could help improve how doctors diagnose conditions like lung cancer and sarcoidosis, which is a disease that causes inflammation in the lungs.

To participate in this trial, you need to be at least 18 years old and undergoing bronchoscopy for diagnosis or staging of your condition. You should also be able to provide informed consent, meaning you understand the study and agree to participate. However, if you have certain health conditions, like bleeding disorders or are pregnant, you won’t be eligible to join. If you do participate, you can expect to have your biopsy samples collected as part of your regular care, and then they will be examined using the new imaging technique alongside the standard methods. This could contribute to better diagnostic practices for lung diseases in the future.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Inpatients or outpatients greater than or equal to 18 years old
  • Capable of providing informed consent
  • Undergoing bronchoscopy for diagnosis or staging per standard of care
  • Collection of small biopsy samples by EBUS or conventional transbronchial needle aspiration (TBNA) or transbronchial biopsy for purposes outside of the research study
  • Exclusion Criteria:
  • Standard contraindications bronchoscopy including bleeding disorders, antiplatelet or anticoagulant usage, severe respiratory failure, and clinical instability
  • Pregnancy

About Johns Hopkins University

Johns Hopkins University, a prestigious research institution located in Baltimore, Maryland, is renowned for its commitment to advancing medical science and public health through innovative clinical trials. With a rich history of groundbreaking research and a multidisciplinary approach, the university's clinical trial initiatives focus on translating scientific discoveries into effective treatments and interventions. Leveraging state-of-the-art facilities and a collaborative network of experts, Johns Hopkins University conducts rigorous clinical studies that aim to improve patient outcomes and address critical health challenges. Its dedication to ethical standards and participant safety underscores its role as a leader in clinical research.

Locations

Baltimore, Maryland, United States

Patients applied

0 patients applied

Trial Officials

Jeffrey Thiboutot, MD

Principal Investigator

Johns Hopkins University

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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