Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

Launched by JOHNS HOPKINS UNIVERSITY · Dec 10, 2021

Keywords

ClinConnect Summary

This clinical trial is exploring a new way to examine small tissue samples taken from the lungs during a procedure called bronchoscopy, which doctors use to look inside the lungs and take biopsies (small samples of tissue). The trial aims to compare a special imaging technique called full-field optical coherence tomography (FFOCT) with the standard method of examining these biopsy samples under a microscope. This research could help improve how doctors diagnose conditions like lung cancer and sarcoidosis, which is a disease that causes inflammation in the lungs.

To participate in this trial, you need to be at least 18 years old and undergoing bronchoscopy for diagnosis or staging of your condition. You should also be able to provide informed consent, meaning you understand the study and agree to participate. However, if you have certain health conditions, like bleeding disorders or are pregnant, you won’t be eligible to join. If you do participate, you can expect to have your biopsy samples collected as part of your regular care, and then they will be examined using the new imaging technique alongside the standard methods. This could contribute to better diagnostic practices for lung diseases in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Inpatients or outpatients greater than or equal to 18 years old
• • Capable of providing informed consent
• • Undergoing bronchoscopy for diagnosis or staging per standard of care
• • Collection of small biopsy samples by EBUS or conventional transbronchial needle aspiration (TBNA) or transbronchial biopsy for purposes outside of the research study
• Exclusion Criteria:
• • Standard contraindications bronchoscopy including bleeding disorders, antiplatelet or anticoagulant usage, severe respiratory failure, and clinical instability
• • Pregnancy