Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Launched by NRG ONCOLOGY · Dec 13, 2021
Trial Information
Current as of July 24, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial, titled "Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease," is looking at how to best choose chemotherapy treatments for patients with Stage III colon cancer after their surgery. The researchers want to see if the presence of a specific type of tumor DNA in the blood, called circulating tumor DNA (ctDNA), can help guide the decision on which chemotherapy drugs to use. This study is currently recruiting participants who are between 65 to 74 years old, and it is open to all genders.
To be eligible for the trial, patients must have had successful surgery to remove their colon cancer and should not have any signs of cancer spread to other parts of the body. They should have a certain level of health as determined by their doctor. Participants will provide a blood sample for testing ctDNA after their surgery and may receive chemotherapy based on the results. It’s important for potential participants to know that this study may involve multiple treatment options and monitoring, which can help improve their chances of a successful recovery.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • The patient must have an ECOG performance status of 0 or 1.
- • Patients must have histologically/pathologically confirmed Stage IIB, IIC, or Stage III colon adenocarcinoma with R0 resection according to AJCC 8th edition criteria.
- • No radiographic evidence of overt metastatic disease within 45 days prior to Step 1/Study entry (CT with IV contrast or MRI imaging is acceptable and must include chest, abdomen, and pelvis).
- • The distal extent of the tumor must be greater than or equal to 12 cm from the anal verge on colonoscopy or above the peritoneal reflection as documented during surgery or on pathology specimen (i.e., excluding rectal adenocarcinomas warranting treatment with chemoradiation).
- • The patient must have had an en bloc complete gross resection of tumor (curative resection). Patients who have had a two-stage surgical procedure, to first provide a decompressive colostomy and then in a later procedure to have the definitive surgical resection, are eligible.
- • The resected tumor specimen and a blood specimen from patients with Stage IIB, IIC, or Stage III colon cancer must have central testing for ctDNA using the Signatera™ assay by Natera (after Step 1/Study entry and before Step2/Randomization). Patient must have sufficient tissue to meet protocol requirements. This blood specimen for the Signatera assay must be collected after surgery (and recommended at least 14 days post surgery).
- • Tumor must be documented as microsatellite stable or have intact mismatch repair proteins through CLIA-approved laboratory testing. Patients whose tumors are MSI-H or dMMR are excluded.
- • The treating investigator must deem the patient a candidate for all potential agents used in this trial (5FU, LV, oxaliplatin and irinotecan).
- • The interval between surgery (post-operative Day 7) and Step 1/Study entry must be no more than 60 days. NOTE: Step 1/Study Entry may occur as early as post operative Day 7, but it cannot occur beyond 60 days from the actual date of the patient's surgery.
- • Availability and provision of adequate surgical tumor tissue for molecular diagnostics and confirmatory profiling.
- Adequate hematologic function within 28 days before Step 1/Study entry defined as follows:
- • Absolute neutrophil count (ANC) must be greater than or equal to 1500/mm3;
- • Participants with benign ethnic neutropenia (BEN): ANC less than 1300 mm3 are eligible.
- • BEN (also known as constitutional neutropenia) is an inherited cause of mild or moderate neutropenia that is not associated with any increased risk for infections or other clinical manifestations. BEN is referred to as ethnic neutropenia because of its increased prevalence in people of African descent and other specific ethnic groups.
- • Platelet count must be greater than or equal to 100,000/mm3; and
- • Hemoglobin must be greater than or equal to 9 g/dL.
- Adequate hepatic function within 28 days before Step 1/Study entry defined as follows:
- • total bilirubin must be less than or equal to ULN (upper limit of normal) for the lab and
- • alkaline phosphatase must be less than 2.5 x ULN for the lab; and
- • AST and ALT must be less than 2.5 x ULN for the lab.
- • Adequate renal function within 28 days before Step 1/Study entry defined as serum creatinine less than or equal to 1.5 x ULN for the lab or measured or calculated creatinine clearance greater than or equal to 50 mL/min using the Cockroft-Gault formula for patients with creatinine levels greater than 1.5 x ULN for the lab.
- • For Women Creatinine Clearance (mL/min) = (140 - age) x weight (kg) x 0.85 72 x serum creatinine (mg/dL) For Men Creatinine Clearance (mL/min) = (140 - age) x weight (kg) 72 x serum creatinine (mg/dL) NOTE: Adjusted body weight (AdjBW) should be used for patients that have BMI greater than or equal to 28 (less than or equal to 30% above IBW).
- • HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial.
- • Pregnancy test (urine or serum according to institutional standard) done within 14 days before Step 1/Study entry must be negative (for women of childbearing potential only).
- • Patients receiving a coumarin-derivative anticoagulant must agree to weekly monitoring of INR if they are randomized to Arm 1 or Arm 3 and receive capecitabine.
- • Eligibility Criteria for Cohort A Arm-2 patients on Second Randomization
- • Patient must have developed a ctDNA +ve assay during serial monitoring.
- • Patient's willingness to be re-randomized affirmed.
- • The patient must continue to have an ECOG performance status of 0 or 1.
- • No radiographic evidence of overt metastatic disease.
- • Pregnancy test (urine or serum according to institutional standard) done within 14 days before second randomization must be negative (for women of childbearing potential only).
- Adequate hematologic function within 28 days before second randomization defined as follows:
- • Absolute neutrophil count (ANC) must be greater than or equal to 1500/mm3;
- • Participants with benign ethnic neutropenia (BEN): ANC less than 1300 mm3 are eligible.
- • BEN (also known as constitutional neutropenia) is an inherited cause of mild or moderate neutropenia that is not associated with any increased risk for infections or other clinical manifestations. BEN is referred to as ethnic neutropenia because of its increased prevalence in people of African descent and other specific ethnic groups.
- • Platelet count must be greater than or equal to 100,000/mm3; and
- • Hemoglobin must be greater than or equal to 9 g/dL.
- Adequate hepatic function within 28 days before second randomization defined as follows:
- • total bilirubin must be less than or equal to ULN (upper limit of normal) for the lab and
- • alkaline phosphatase must be less than 2.5 x ULN for the lab; and
- • AST and ALT must be less than 2.5 x ULN for the lab.
- • Adequate renal function within 28 days before second randomization defined as serum creatinine less than or equal to 1.5 x ULN for the lab or measured or calculated creatinine clearance greater than or equal to 50 mL/min using the Cockroft-Gault formula for patients with creatinine levels greater than 1.5 x ULN for the lab.
- • For Women Creatinine Clearance (mL/min) = (140 - age) x weight (kg) x 0.85 72 x serum creatinine (mg/dL) For Men Creatinine Clearance (mL/min) = (140 - age) x weight (kg) 72 x serum creatinine (mg/dL)
- Exclusion Criteria:
- • Colon cancer histology other than adenocarcinoma (i.e., neuroendocrine carcinoma, sarcoma, lymphoma, squamous cell carcinoma, etc.).
- • Pathologic, clinical, or radiologic overt evidence of metastatic disease. This includes isolated, distant, or non-contiguous intra-abdominal metastases, even if resected.
- • Tumor-related bowel perforation.
- • History of prior invasive colon malignancy, regardless of disease-free interval.
- • History of bone marrow or solid organ transplantation (regardless of current immunosuppressive therapy needs). Bone grafts, skin grafts, corneal transplants and organ/tissue donation are not exclusionary.
- • Any prior systemic chemotherapy, targeted therapy, or immunotherapy; or radiation therapy administered as treatment for colorectal cancer (e.g., primary colon adenocarcinomas for which treatment with neoadjuvant chemotherapy and/or radiation is warranted are not permitted). EXCEPTION: one cycle of chemotherapy (regimen per treating physicians' discretion - 5-FU or capecitabine with or without oxaliplatin) is allowed but not required after consent. The optional cycle of chemotherapy should be started greater than or equal to 4 weeks from surgery and while awaiting Step 2 randomization.
- • Other invasive malignancy within 5 years before Step 1/Study entry. Exceptions are colonic polyps, non-melanoma skin cancer or any carcinoma-in-situ.
- • Synchronous primary rectal and/ or colon cancers.
- • Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better.
- • Sensory or motor neuropathy greater than or equal to grade 2, according to CTCAE v5.0.
- • Blood transfusion within two weeks before collection of blood for central ctDNA testing.
- • Active seizure disorder uncontrolled by medication.
- • Active or chronic infection requiring systemic therapy.
- • Known homozygous DPD (dihydropyrimidine dehydrogenase) deficiency.
- • Patients known to have Gilbert's Syndrome or homozygosity for UGT1A1\*28 polymorphism.
- • Pregnancy or lactation at the time of Step 1/Study entry.
- • Co-morbid illnesses or other concurrent disease that would make the patient inappropriate for entry into this study (i.e., unable to tolerate 6 months of combination chemotherapy or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens or prevent required follow-up).
- • Ineligibility Criteria for Cohort A Arm-2 patients on Second Randomization
- • Pregnancy or lactation at the time of randomization.
- • No longer a candidate for systemic chemotherapy (FOLFOX, CAPOX, and mFOLFIRINOX) in the opinion of the treating investigator.
About Nrg Oncology
NRG Oncology is a prominent clinical trial sponsor dedicated to advancing cancer research through innovative multi-institutional studies. Comprising a collaborative network of leading academic institutions and community hospitals, NRG Oncology focuses on enhancing patient outcomes by conducting rigorous clinical trials that evaluate new treatment strategies and improve existing therapies. With a commitment to scientific excellence and patient-centered care, the organization plays a vital role in shaping the future of oncology by integrating cutting-edge research with clinical practice, ultimately striving to translate findings into meaningful improvements in cancer care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Bakersfield, California, United States
Newport Beach, California, United States
Milford, Delaware, United States
Weston, Florida, United States
Atlanta, Georgia, United States
Lawrenceville, Georgia, United States
Downers Grove, Illinois, United States
Saint Peters, Missouri, United States
Grafton, Wisconsin, United States
Green Bay, Wisconsin, United States
Kenosha, Wisconsin, United States
Milwaukee, Wisconsin, United States
Rhinelander, Wisconsin, United States
Grayslake, Illinois, United States
Danville, Pennsylvania, United States
Hazleton, Pennsylvania, United States
Phoenixville, Pennsylvania, United States
Mobile, Alabama, United States
Oakland, California, United States
Effingham, Illinois, United States
Lansing, Michigan, United States
Fresh Meadows, New York, United States
Monticello, Minnesota, United States
Omaha, Nebraska, United States
Londonderry, New Hampshire, United States
Los Angeles, California, United States
Torrance, California, United States
Evanston, Illinois, United States
Marinette, Wisconsin, United States
South San Francisco, California, United States
Baton Rouge, Louisiana, United States
Marrero, Louisiana, United States
Glenview, Illinois, United States
Brighton, Massachusetts, United States
Saint Louis, Missouri, United States
Cherry Hill, New Jersey, United States
Pinehurst, North Carolina, United States
Yankton, South Dakota, United States
Amarillo, Texas, United States
Edmonds, Washington, United States
Toronto, Ontario, Canada
Westminster, Maryland, United States
Omaha, Nebraska, United States
Janesville, Wisconsin, United States
Oshkosh, Wisconsin, United States
Erie, Pennsylvania, United States
Lancaster, California, United States
Aurora, Colorado, United States
Caldwell, Idaho, United States
Jefferson, Iowa, United States
Louisville, Kentucky, United States
Methuen, Massachusetts, United States
Farmington, Missouri, United States
Jersey City, New Jersey, United States
Littleton, Colorado, United States
Parker, Colorado, United States
'Ewa Beach, Hawaii, United States
Des Moines, Iowa, United States
Des Moines, Iowa, United States
Overland Park, Kansas, United States
Biddeford, Maine, United States
Sanford, Maine, United States
South Portland, Maine, United States
Winchester, Massachusetts, United States
Escanaba, Michigan, United States
Cape Girardeau, Missouri, United States
Rolla, Missouri, United States
Las Cruces, New Mexico, United States
Lewisburg, Pennsylvania, United States
Sheboygan, Wisconsin, United States
Calgary, Alberta, Canada
Dublin, California, United States
Longmont, Colorado, United States
Longmont, Colorado, United States
New Haven, Connecticut, United States
Washington, District Of Columbia, United States
Decatur, Illinois, United States
Honolulu, Hawaii, United States
Coeur D'alene, Idaho, United States
Mechanicsburg, Pennsylvania, United States
Minocqua, Wisconsin, United States
Racine, Wisconsin, United States
Waukesha, Wisconsin, United States
Williamsburg, Virginia, United States
Washington, District Of Columbia, United States
Eureka, Illinois, United States
Libertyville, Illinois, United States
Ankeny, Iowa, United States
Des Moines, Iowa, United States
Des Moines, Iowa, United States
Detroit, Michigan, United States
Macomb, Michigan, United States
Novi, Michigan, United States
Warren, Michigan, United States
Morristown, New Jersey, United States
Summit, New Jersey, United States
American Fork, Utah, United States
Cedar City, Utah, United States
Ogden, Utah, United States
Provo, Utah, United States
Salt Lake City, Utah, United States
Cudahy, Wisconsin, United States
Saint John, New Brunswick, Canada
Milwaukee, Wisconsin, United States
Lafayette, Colorado, United States
Thief River Falls, Minnesota, United States
Middletown, New York, United States
Cincinnati, Ohio, United States
Saint Louis Park, Minnesota, United States
Des Moines, Iowa, United States
Vallejo, California, United States
Lakewood, Colorado, United States
Novi, Michigan, United States
Ypsilanti, Michigan, United States
Springfield, Missouri, United States
Las Vegas, Nevada, United States
Findlay, Ohio, United States
Greenwich, Connecticut, United States
Danville, Illinois, United States
Washington, Illinois, United States
Lutherville, Maryland, United States
Chelsea, Michigan, United States
Los Angeles, California, United States
Crystal Lake, Illinois, United States
Mineola, New York, United States
Lancaster, Ohio, United States
Germantown, Wisconsin, United States
Neillsville, Wisconsin, United States
West Allis, Wisconsin, United States
Parker, Colorado, United States
Beavercreek, Ohio, United States
Cambridge, Ontario, Canada
Southfield, Michigan, United States
Wilkes Barre, Pennsylvania, United States
Los Angeles, California, United States
Dover, Delaware, United States
Emeryville, California, United States
'Aiea, Hawaii, United States
Reed City, Michigan, United States
Chardon, Ohio, United States
Grosse Pointe Woods, Michigan, United States
Effingham, Illinois, United States
Rapid City, South Dakota, United States
Prince George, British Columbia, Canada
Sioux City, Iowa, United States
New York, New York, United States
Elk Grove, California, United States
Fremont, California, United States
Sacramento, California, United States
Sacramento, California, United States
New Orleans, Louisiana, United States
Grand Rapids, Michigan, United States
Mentor, Ohio, United States
Newberg, Oregon, United States
Portland, Oregon, United States
Germantown, Tennessee, United States
Galveston, Texas, United States
Crown Point, Indiana, United States
Mitchell, South Dakota, United States
Marysville, California, United States
Houston, Texas, United States
Elgin, Illinois, United States
Beachwood, Ohio, United States
New Ulm, Minnesota, United States
Perrysburg, Ohio, United States
Saint Johnsbury, Vermont, United States
Cary, North Carolina, United States
Raleigh, North Carolina, United States
Belpre, Ohio, United States
Cleveland, Ohio, United States
Grosse Pointe Woods, Michigan, United States
Dublin, California, United States
Fountain Valley, California, United States
Stockton, California, United States
Honolulu, Hawaii, United States
Bloomington, Illinois, United States
Louisville, Kentucky, United States
Saint Louis, Missouri, United States
Mobile, Alabama, United States
Bismarck, North Dakota, United States
Saint George, Utah, United States
Baton Rouge, Louisiana, United States
Biddeford, Maine, United States
South Portland, Maine, United States
Boardman, Ohio, United States
Natrona Heights, Pennsylvania, United States
New Castle, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Rancho Mirage, California, United States
Fort Wayne, Indiana, United States
Ankeny, Iowa, United States
Clive, Iowa, United States
Ephrata, Pennsylvania, United States
Gettysburg, Pennsylvania, United States
York, Pennsylvania, United States
Waupaca, Wisconsin, United States
Montreal, Quebec, Canada
Quebec City, Quebec, Canada
Los Angeles, California, United States
Jackson, Mississippi, United States
Franklin, Ohio, United States
Greenville, Ohio, United States
Troy, Ohio, United States
Dallas, Texas, United States
Newnan, Georgia, United States
Eau Claire, Wisconsin, United States
Sheboygan, Wisconsin, United States
Fremont, California, United States
York, Pennsylvania, United States
Lake Success, New York, United States
Barrie, Ontario, Canada
Colorado Springs, Colorado, United States
Carlisle, Pennsylvania, United States
Salinas, California, United States
Las Vegas, Nevada, United States
New York, New York, United States
Victoria, British Columbia, Canada
Little Rock, Arkansas, United States
Creston, Iowa, United States
Des Moines, Iowa, United States
Fort Dodge, Iowa, United States
New York, New York, United States
Gaithersburg, Maryland, United States
Reed City, Michigan, United States
Saint Joseph, Michigan, United States
Lima, Ohio, United States
Lebanon, New Hampshire, United States
Upland, California, United States
Dublin, Ohio, United States
Fort Smith, Arkansas, United States
Livonia, Michigan, United States
South Pasadena, California, United States
Brighton, Massachusetts, United States
Orlando, Florida, United States
Barberton, Ohio, United States
Dayton, Ohio, United States
Philadelphia, Pennsylvania, United States
Mclean, Virginia, United States
Ladysmith, Wisconsin, United States
Wauwatosa, Wisconsin, United States
Saskatoon, Saskatchewan, Canada
Baldwin Park, California, United States
Centerville, Ohio, United States
Alton, Illinois, United States
Pittsburgh, Pennsylvania, United States
Laguna Hills, California, United States
Fort Collins, Colorado, United States
New Haven, Connecticut, United States
Washington, District Of Columbia, United States
Nampa, Idaho, United States
Marshalltown, Iowa, United States
West Des Moines, Iowa, United States
Grand Rapids, Michigan, United States
Pittsburgh, Pennsylvania, United States
Willow Grove, Pennsylvania, United States
Appleton, Wisconsin, United States
Enumclaw, Washington, United States
North Haven, Connecticut, United States
Bozeman, Montana, United States
Newark, New Jersey, United States
Newark, Ohio, United States
Ontario, Oregon, United States
'Aiea, Hawaii, United States
Moline, Illinois, United States
Mount Vernon, Illinois, United States
Santa Rosa, California, United States
Albuquerque, New Mexico, United States
Lebanon, Pennsylvania, United States
Clive, Iowa, United States
Walnut Creek, California, United States
Denver, Colorado, United States
Jupiter, Florida, United States
Riverton, Utah, United States
Ashland, Wisconsin, United States
Post Falls, Idaho, United States
Canton, Michigan, United States
Covington, Louisiana, United States
Chambersburg, Pennsylvania, United States
San Marcos, California, United States
San Rafael, California, United States
Newark, Delaware, United States
Aurora, Illinois, United States
Springfield, Illinois, United States
Waukee, Iowa, United States
Baltimore, Maryland, United States
Glen Burnie, Maryland, United States
Grosse Pointe Woods, Michigan, United States
Robbinsdale, Minnesota, United States
Jefferson City, Missouri, United States
Las Vegas, Nevada, United States
Cary, North Carolina, United States
Canton, Ohio, United States
Issaquah, Washington, United States
Kitchener, Ontario, Canada
Webster, New York, United States
Great Falls, Montana, United States
Minneapolis, Minnesota, United States
New Brunswick, New Jersey, United States
Maple Grove, Minnesota, United States
Minneapolis, Minnesota, United States
Brooklyn, New York, United States
Findlay, Ohio, United States
Fargo, North Dakota, United States
Hazleton, Pennsylvania, United States
Los Angeles, California, United States
Sandusky, Ohio, United States
Springfield, Ohio, United States
Bremerton, Washington, United States
Atlanta, Georgia, United States
Chicago, Illinois, United States
Chillicothe, Ohio, United States
Dayton, Ohio, United States
Mckeesport, Pennsylvania, United States
Woodland Hills, California, United States
Stockbridge, Georgia, United States
Westerville, Ohio, United States
Clackamas, Oregon, United States
Gloucester, Virginia, United States
Guilford, Connecticut, United States
Stony Brook, New York, United States
Danville, Illinois, United States
Orange, California, United States
Torrington, Connecticut, United States
Honolulu, Hawaii, United States
Elmhurst, Illinois, United States
Springfield, Illinois, United States
Louisville, Kentucky, United States
Louisville, Kentucky, United States
Flint, Michigan, United States
Bolivar, Missouri, United States
Dayton, Ohio, United States
Ottawa, Illinois, United States
Rockford, Illinois, United States
Jefferson City, Missouri, United States
Henderson, Nevada, United States
Wooster, Ohio, United States
Sturgeon Bay, Wisconsin, United States
Newark, Delaware, United States
'Aiea, Hawaii, United States
Fontana, California, United States
Vacaville, California, United States
Orange, Connecticut, United States
Tampa, Florida, United States
Duluth, Georgia, United States
Shepherdsville, Kentucky, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Great Falls, Montana, United States
Renton, Washington, United States
Eau Claire, Wisconsin, United States
Medford, Wisconsin, United States
Rice Lake, Wisconsin, United States
Redwood City, California, United States
Denver, Colorado, United States
Hartford, Connecticut, United States
Springfield, Illinois, United States
Yorkville, Illinois, United States
Boone, Iowa, United States
Corbin, Kentucky, United States
Ravenna, Ohio, United States
Wadsworth, Ohio, United States
Warrenville, Illinois, United States
New York, New York, United States
Greenville, Ohio, United States
Springfield, Ohio, United States
Lone Tree, Colorado, United States
Stamford, Connecticut, United States
Plainfield, Illinois, United States
Cape Girardeau, Missouri, United States
Sunset Hills, Missouri, United States
Marietta, Ohio, United States
Kalamazoo, Michigan, United States
Rio Rancho, New Mexico, United States
Kingman, Arizona, United States
Southfield, Michigan, United States
Reno, Nevada, United States
Camp Hill, Pennsylvania, United States
Green Bay, Wisconsin, United States
Lincoln, Nebraska, United States
Somerville, New Jersey, United States
Houston, Texas, United States
Richmond, Virginia, United States
Denver, Colorado, United States
Chicago, Illinois, United States
Grosse Pointe Woods, Michigan, United States
Staten Island, New York, United States
Charleston, West Virginia, United States
Menomonee Falls, Wisconsin, United States
Flint, Michigan, United States
Perrysburg, Ohio, United States
Guilford, Connecticut, United States
Cedar Rapids, Iowa, United States
Albuquerque, New Mexico, United States
Joplin, Missouri, United States
Aurora, Colorado, United States
Elizabeth, New Jersey, United States
Greenville, South Carolina, United States
Logan, Utah, United States
Murray, Utah, United States
Loma Linda, California, United States
Charleston, South Carolina, United States
Oak Creek, Wisconsin, United States
Toledo, Ohio, United States
Marshfield, Wisconsin, United States
Woodbury, Minnesota, United States
Milwaukee, Wisconsin, United States
Edina, Minnesota, United States
Arroyo Grande, California, United States
Morgantown, West Virginia, United States
Rocklin, California, United States
Worthington, Minnesota, United States
Ballwin, Missouri, United States
Newark, New Jersey, United States
Las Cruces, New Mexico, United States
Flushing, New York, United States
Burke, Virginia, United States
Lexington, Kentucky, United States
Grosse Pointe Woods, Michigan, United States
Mattoon, Illinois, United States
Macomb, Illinois, United States
Carthage, Illinois, United States
Los Angeles, California, United States
Orlando, Florida, United States
Carterville, Illinois, United States
Caro, Michigan, United States
Clarkston, Michigan, United States
Princeton, Minnesota, United States
Newport News, Virginia, United States
Burien, Washington, United States
Shakopee, Minnesota, United States
Omaha, Nebraska, United States
Papillion, Nebraska, United States
Columbus, Ohio, United States
Williamsport, Pennsylvania, United States
Farrell, Pennsylvania, United States
Johnstown, Pennsylvania, United States
Sacramento, California, United States
Santa Clara, California, United States
Dearborn, Michigan, United States
Detroit, Michigan, United States
Macomb, Michigan, United States
Saginaw, Michigan, United States
Southhaven, Mississippi, United States
Rolla, Missouri, United States
Federal Way, Washington, United States
Mukwonago, Wisconsin, United States
Lexington, Kentucky, United States
Irvine, California, United States
West Bend, Wisconsin, United States
Hamilton, New Jersey, United States
Harrisburg, Pennsylvania, United States
New Richmond, Wisconsin, United States
Ann Arbor, Michigan, United States
Scranton, Pennsylvania, United States
Milwaukee, Wisconsin, United States
Ames, Iowa, United States
Beverly Hills, California, United States
Bettendorf, Iowa, United States
Washington, Pennsylvania, United States
Greenville, South Carolina, United States
Bridgeport, West Virginia, United States
Arroyo Grande, California, United States
Ontario, California, United States
Chelsea, Michigan, United States
Clarkston, Michigan, United States
Wyoming, Michigan, United States
Ypsilanti, Michigan, United States
Branson, Missouri, United States
Columbia, Missouri, United States
Bronx, New York, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Cleveland, Ohio, United States
Oklahoma City, Oklahoma, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Berlin, Wisconsin, United States
Martinez, California, United States
Pittsburgh, Pennsylvania, United States
Johnson Creek, Wisconsin, United States
O'fallon, Illinois, United States
Orland Park, Illinois, United States
Peoria, Illinois, United States
Akron, Ohio, United States
Akron, Ohio, United States
Youngstown, Ohio, United States
Zanesville, Ohio, United States
Green Bay, Wisconsin, United States
Johnson Creek, Wisconsin, United States
Greenville, South Carolina, United States
Augusta, Maine, United States
Washington, District Of Columbia, United States
New Orleans, Louisiana, United States
Saint Joseph, Missouri, United States
Glens Falls, New York, United States
Manchester, New Hampshire, United States
Durham, North Carolina, United States
Athens, Georgia, United States
Baltimore, Maryland, United States
Oregon City, Oregon, United States
Austin, Texas, United States
Wheeling, West Virginia, United States
Fairhope, Alabama, United States
Phoenix, Arizona, United States
Laguna Hills, California, United States
Los Angeles, California, United States
Riverside, California, United States
Santa Maria, California, United States
San Jose, California, United States
Walnut Creek, California, United States
Truckee, California, United States
Derby, Connecticut, United States
Littleton, Colorado, United States
Garden City, Kansas, United States
Brighton, Michigan, United States
Urbana, Illinois, United States
Grosse Pointe Woods, Michigan, United States
East China Township, Michigan, United States
Missoula, Montana, United States
Warren, Michigan, United States
Clinton, North Carolina, United States
Garner, North Carolina, United States
Grenada, Mississippi, United States
Newark, Ohio, United States
Dublin, Ohio, United States
Steubenville, Ohio, United States
Parma, Ohio, United States
West Chester, Ohio, United States
Strongsville, Ohio, United States
Monroeville, Pennsylvania, United States
Clackamas, Oregon, United States
Eau Claire, Wisconsin, United States
Chesapeake, Virginia, United States
Carmichael, California, United States
Kewanee, Illinois, United States
Richmond, Virginia, United States
New Lenox, Illinois, United States
Greer, South Carolina, United States
San Leandro, California, United States
Concord, New Hampshire, United States
La Crosse, Wisconsin, United States
Phoenix, Arizona, United States
Glastonbury, Connecticut, United States
Cameron Park, California, United States
Carmichael, California, United States
Hot Springs, Arkansas, United States
Honolulu, Hawaii, United States
Trumbull, Connecticut, United States
Galesburg, Illinois, United States
Sandpoint, Idaho, United States
Aurora, Illinois, United States
Galesburg, Illinois, United States
Maywood, Illinois, United States
Geneva, Illinois, United States
Naperville, Illinois, United States
Sanford, Maine, United States
Hines, Illinois, United States
Cumberland, Maryland, United States
Baltimore, Maryland, United States
Bel Air, Maryland, United States
Stillwater, Minnesota, United States
Willmar, Minnesota, United States
Wyoming, Minnesota, United States
Anaconda, Montana, United States
Billings, Montana, United States
Kalispell, Montana, United States
Grand Island, Nebraska, United States
Largo, Maryland, United States
Columbus, Ohio, United States
Carson City, Nevada, United States
Henderson, Nevada, United States
Delaware, Ohio, United States
Toledo, Ohio, United States
Marion, Ohio, United States
Middleburg Heights, Ohio, United States
Troy, Ohio, United States
Warrensville Heights, Ohio, United States
Pittsburgh, Pennsylvania, United States
Sioux Falls, South Dakota, United States
Sioux Falls, South Dakota, United States
Collierville, Tennessee, United States
Uniontown, Pennsylvania, United States
Bryan, Texas, United States
Farmington, Utah, United States
Suffolk, Virginia, United States
Virginia Beach, Virginia, United States
La Crosse, Wisconsin, United States
Lynchburg, Virginia, United States
Waterbury, Connecticut, United States
South Weymouth, Massachusetts, United States
Oconomowoc, Wisconsin, United States
Joplin, Missouri, United States
Flint, Michigan, United States
Wichita, Kansas, United States
Wichita, Kansas, United States
London, Kentucky, United States
Boston, Massachusetts, United States
Lake Forest, Illinois, United States
Foxboro, Massachusetts, United States
Lincoln, Nebraska, United States
Highlands Ranch, Colorado, United States
Gainesville, Florida, United States
Carbondale, Illinois, United States
New Orleans, Louisiana, United States
Saint Louis, Missouri, United States
Allentown, Pennsylvania, United States
Altoona, Pennsylvania, United States
Toms River, New Jersey, United States
New York, New York, United States
Seneca, South Carolina, United States
Maplewood, Minnesota, United States
Cleveland, Ohio, United States
Honolulu, Hawaii, United States
Sterling Heights, Michigan, United States
Saint Louis, Missouri, United States
Greenlawn, New York, United States
Cary, North Carolina, United States
Jonesboro, Arkansas, United States
Tawas City, Michigan, United States
Sainte Genevieve, Missouri, United States
New Albany, Ohio, United States
Anaheim, California, United States
Dyer, Indiana, United States
Columbus, Ohio, United States
Golden, Colorado, United States
Columbus, Ohio, United States
Mansfield, Ohio, United States
Indiana, Pennsylvania, United States
Glenview, Illinois, United States
Canton, Illinois, United States
Bardstown, Kentucky, United States
Chapel Hill, North Carolina, United States
Reno, Nevada, United States
Butler, Pennsylvania, United States
Baltimore, Maryland, United States
Nashville, Tennessee, United States
Kalamazoo, Michigan, United States
Wyoming, Michigan, United States
Irvine, California, United States
Colorado Springs, Colorado, United States
Indianapolis, Indiana, United States
Cranberry Township, Pennsylvania, United States
Martinsburg, West Virginia, United States
Louisville, Kentucky, United States
Baltimore, Maryland, United States
Flint, Michigan, United States
Las Vegas, Nevada, United States
Cedar Rapids, Iowa, United States
Louisville, Kentucky, United States
New York, New York, United States
Goldsboro, North Carolina, United States
Kettering, Ohio, United States
Mansfield, Ohio, United States
Portsmouth, Ohio, United States
Regina, Saskatchewan, Canada
Torrance, California, United States
Pekin, Illinois, United States
Macomb, Michigan, United States
Houston, Texas, United States
Columbus, Ohio, United States
Tulsa, Oklahoma, United States
Hendersonville, North Carolina, United States
Roseville, California, United States
Parkersburg, West Virginia, United States
Colorado Springs, Colorado, United States
Harvey, Illinois, United States
Richmond, California, United States
Sacramento, California, United States
Saint Cloud, Minnesota, United States
Pittsburgh, Pennsylvania, United States
Seneca, Pennsylvania, United States
Colorado Springs, Colorado, United States
Chicago, Illinois, United States
Loveland, Colorado, United States
Durango, Colorado, United States
Fort Collins, Colorado, United States
Muskegon, Michigan, United States
Clive, Iowa, United States
Saint Joseph, Michigan, United States
Royal Oak, Michigan, United States
Warren, Michigan, United States
Burnsville, Minnesota, United States
Warren, Michigan, United States
Cambridge, Minnesota, United States
Oxford, Mississippi, United States
Saint Paul, Minnesota, United States
Waconia, Minnesota, United States
Kearney, Nebraska, United States
Centerville, Ohio, United States
Lakewood, New Jersey, United States
Livingston, New Jersey, United States
Cleveland, Ohio, United States
Hershey, Pennsylvania, United States
Columbus, Ohio, United States
Gahanna, Ohio, United States
Madison, Wisconsin, United States
Aberdeen, South Dakota, United States
Sioux Falls, South Dakota, United States
West Branch, Michigan, United States
Columbus, Ohio, United States
Shiloh, Illinois, United States
Rochester, Minnesota, United States
Great Bend, Kansas, United States
Edinburg, Texas, United States
Pittsburgh, Pennsylvania, United States
Burlington, Vermont, United States
Lakewood, Washington, United States
Lone Tree, Colorado, United States
San Diego, California, United States
Dekalb, Illinois, United States
Fayetteville, Georgia, United States
Columbus, Mississippi, United States
Battle Creek, Michigan, United States
Canton, Michigan, United States
N. Huntingdon, Pennsylvania, United States
Delaware, Ohio, United States
Salt Lake City, Utah, United States
Berlin, Vermont, United States
Findlay, Ohio, United States
Centralia, Illinois, United States
Denver, Colorado, United States
Portland, Oregon, United States
Ann Arbor, Michigan, United States
Pierre, South Dakota, United States
Moon, Pennsylvania, United States
Chicago, Illinois, United States
Alliance, Ohio, United States
Franklin, Ohio, United States
Tampa, Florida, United States
Antioch, California, United States
Tampa, Florida, United States
Marlette, Michigan, United States
Troy, Michigan, United States
Rolla, Missouri, United States
Saint Louis, Missouri, United States
Springfield, Missouri, United States
Raleigh, North Carolina, United States
Raleigh, North Carolina, United States
Hobart, Indiana, United States
York, Pennsylvania, United States
Winston Salem, North Carolina, United States
Harbor City, California, United States
Peru, Illinois, United States
Westerly, Rhode Island, United States
Princeton, Illinois, United States
Pontiac, Michigan, United States
Norton Shores, Michigan, United States
Burnsville, Minnesota, United States
Pontiac, Michigan, United States
Coon Rapids, Minnesota, United States
Westlake, Ohio, United States
New Albany, Mississippi, United States
Pittsburgh, Pennsylvania, United States
Portland, Oregon, United States
Colorado Springs, Colorado, United States
Los Angeles, California, United States
Dayton, Ohio, United States
Woodland, California, United States
Edwards, Colorado, United States
Albany, Georgia, United States
Baton Rouge, Louisiana, United States
Chelsea, Michigan, United States
Dearborn, Michigan, United States
Dixon, Illinois, United States
Iowa City, Iowa, United States
Royal Oak, Michigan, United States
Hibbing, Minnesota, United States
Detroit Lakes, Minnesota, United States
Duluth, Minnesota, United States
Maplewood, Minnesota, United States
Minneapolis, Minnesota, United States
Rochester, New York, United States
Sandstone, Minnesota, United States
Virginia, Minnesota, United States
Sullivan, Missouri, United States
Rochester, New York, United States
Cincinnati, Ohio, United States
Greer, South Carolina, United States
Mayfield Heights, Ohio, United States
Kitchener, Ontario, Canada
Seattle, Washington, United States
Valparaiso, Indiana, United States
Moose Lake, Minnesota, United States
Newmarket, Ontario, Canada
Newnan, Georgia, United States
Sewell, New Jersey, United States
Ontario, Oregon, United States
Raleigh, North Carolina, United States
Fargo, North Dakota, United States
Spartanburg, South Carolina, United States
Temple, Texas, United States
Bellevue, Washington, United States
York, Pennsylvania, United States
Kirkland, Washington, United States
Ames, Iowa, United States
Seattle, Washington, United States
Gloucester, Massachusetts, United States
Winchester, Massachusetts, United States
Canton, Ohio, United States
Columbus, Ohio, United States
Stevens Point, Wisconsin, United States
Seattle, Washington, United States
Fort Dodge, Iowa, United States
Weston, Wisconsin, United States
Denver, Colorado, United States
Calgary, Alberta, Canada
Creve Coeur, Missouri, United States
Concord, North Carolina, United States
Waterford, Connecticut, United States
Lake Mary, Florida, United States
Peabody, Massachusetts, United States
Saint Paul, Minnesota, United States
Columbia, Missouri, United States
Kansas City, Missouri, United States
Lee's Summit, Missouri, United States
Berkeley Heights, New Jersey, United States
Mount Vernon, Illinois, United States
Oak Lawn, Illinois, United States
Florham Park, New Jersey, United States
Orland Park, Illinois, United States
Park Ridge, Illinois, United States
Aberdeen, Maryland, United States
Charlotte, North Carolina, United States
Charlotte, North Carolina, United States
Charlotte, North Carolina, United States
Stevens Point, Wisconsin, United States
Summit, Wisconsin, United States
Two Rivers, Wisconsin, United States
Wausau, Wisconsin, United States
Wisconsin Rapids, Wisconsin, United States
Charlotte, North Carolina, United States
Monroe, North Carolina, United States
West Chester, Pennsylvania, United States
Kennewick, Washington, United States
Antigo, Wisconsin, United States
Boone, Iowa, United States
Wisconsin Rapids, Wisconsin, United States
Vancouver, British Columbia, Canada
Mount Vernon, Ohio, United States
South Jordan, Utah, United States
Ottawa, Ontario, Canada
Toronto, Ontario, Canada
Burlington, Wisconsin, United States
Pueblo, Colorado, United States
Philadelphia, Pennsylvania, United States
East Stroudsburg, Pennsylvania, United States
Warren, Michigan, United States
Warren, Michigan, United States
Chippewa Falls, Wisconsin, United States
Chicago, Illinois, United States
Grand Junction, Colorado, United States
Lansing, Michigan, United States
Toronto, Ontario, Canada
Toledo, Ohio, United States
Toledo, Ohio, United States
Lancaster, Pennsylvania, United States
Lancaster, Pennsylvania, United States
Fargo, North Dakota, United States
Levis, Quebec, Canada
Montreal, Quebec, Canada
Sylvania, Ohio, United States
London, Ontario, Canada
Fort Lauderdale, Florida, United States
Hollywood, Florida, United States
Honolulu, Hawaii, United States
Pembroke Pines, Florida, United States
Chicago, Illinois, United States
Oklahoma City, Oklahoma, United States
Hamilton, Ontario, Canada
Woodbridge, Virginia, United States
Lexington, Kentucky, United States
Oshkosh, Wisconsin, United States
Highland Park, Illinois, United States
Libertyville, Illinois, United States
Frederick, Maryland, United States
Louisville, Kentucky, United States
Frederick, Maryland, United States
Bemidji, Minnesota, United States
Beverly, Massachusetts, United States
Boston, Massachusetts, United States
Charlotte, North Carolina, United States
Sheboygan, Wisconsin, United States
Wausau, Wisconsin, United States
Saint Catharines, Ontario, Canada
Barrington, Illinois, United States
Richmond, Indiana, United States
Chicago, Illinois, United States
Austin, Texas, United States
Richmond, Virginia, United States
Birmingham, Alabama, United States
Mount Kisco, New York, United States
Sleepy Hollow, New York, United States
Denver, Colorado, United States
Tucson, Arizona, United States
Tucson, Arizona, United States
Grand Rapids, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Grand Island, Nebraska, United States
Golden, Colorado, United States
Savannah, Georgia, United States
Rockford, Illinois, United States
Hobart, Indiana, United States
Albuquerque, New Mexico, United States
Mineola, New York, United States
Johnson Creek, Wisconsin, United States
Dayton, Ohio, United States
Springfield, Ohio, United States
Carmichael, California, United States
Munster, Indiana, United States
Clive, Iowa, United States
Saint Johnsbury, Vermont, United States
Munster, Indiana, United States
Tacoma, Washington, United States
Toledo, Ohio, United States
Bozeman, Montana, United States
Great Falls, Montana, United States
Missoula, Montana, United States
Yakima, Washington, United States
Oshawa, Ontario, Canada
Shawano, Wisconsin, United States
Calgary, Alberta, Canada
Sherbrooke, Quebec, Canada
Hazel Crest, Illinois, United States
Springfield, Illinois, United States
Baton Rouge, Louisiana, United States
East China Township, Michigan, United States
Lynchburg, Virginia, United States
Stevens Point, Wisconsin, United States
Macomb, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
Kingston, Ontario, Canada
Windsor, Ontario, Canada
Jefferson Hills, Pennsylvania, United States
Monroeville, Pennsylvania, United States
Fort Worth, Texas, United States
Houston, Texas, United States
Houston, Texas, United States
Harbor City, California, United States
Dillon, Colorado, United States
Rego Park, New York, United States
Memphis, Tennessee, United States
Alton, Illinois, United States
Bethlehem, Pennsylvania, United States
South Hill, Virginia, United States
Silverdale, Washington, United States
Madison, Wisconsin, United States
Milford, Massachusetts, United States
Jefferson, Iowa, United States
Marshalltown, Iowa, United States
Brighton, Michigan, United States
Erie, Pennsylvania, United States
Ladysmith, Wisconsin, United States
Kalamazoo, Michigan, United States
Boiling Springs, South Carolina, United States
Minocqua, Wisconsin, United States
Sunset Hills, Missouri, United States
Seattle, Washington, United States
Kalispell, Montana, United States
Boise, Idaho, United States
Saginaw, Michigan, United States
Oklahoma City, Oklahoma, United States
New York, New York, United States
Sandpoint, Idaho, United States
Ann Arbor, Michigan, United States
Medina, Ohio, United States
Canton, Michigan, United States
Gastonia, North Carolina, United States
Natrona Heights, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
League City, Texas, United States
Saint Louis, Missouri, United States
Saint Louis, Missouri, United States
Washington, Missouri, United States
Richardson, Texas, United States
Sugar Land, Texas, United States
Greenville, North Carolina, United States
Lawton, Oklahoma, United States
Easley, South Carolina, United States
Neenah, Wisconsin, United States
Rhinelander, Wisconsin, United States
Montreal, Quebec, Canada
Conroe, Texas, United States
Dallas, Texas, United States
Dallas, Texas, United States
Bellflower, California, United States
Duarte, California, United States
Troy, Michigan, United States
Oakland, California, United States
Orange, California, United States
Durango, Colorado, United States
Greeley, Colorado, United States
Peru, Illinois, United States
Urbana, Illinois, United States
Baton Rouge, Louisiana, United States
Avon, Ohio, United States
Dayton, Ohio, United States
Greenville, Ohio, United States
Greensburg, Pennsylvania, United States
Madison, Wisconsin, United States
Greenfield Park, Quebec, Canada
Irvine, California, United States
Fairfield, Connecticut, United States
Decatur, Illinois, United States
Peoria, Illinois, United States
West Reading, Pennsylvania, United States
San Francisco, California, United States
San Luis Obispo, California, United States
Denver, Colorado, United States
Tampa, Florida, United States
Honolulu, Hawaii, United States
Ames, Iowa, United States
Lexington, Kentucky, United States
Pittsburgh, Pennsylvania, United States
Flint, Michigan, United States
Saginaw, Michigan, United States
Long Branch, New Jersey, United States
Rochester, New York, United States
Billings, Montana, United States
Sellersville, Pennsylvania, United States
Salt Lake City, Utah, United States
Omaha, Nebraska, United States
Exeter, New Hampshire, United States
Carroll, Iowa, United States
Council Bluffs, Iowa, United States
Baltimore, Maryland, United States
Brighton, Michigan, United States
Fresno, California, United States
Long Beach, California, United States
Modesto, California, United States
Traverse City, Michigan, United States
Brainerd, Minnesota, United States
Deer River, Minnesota, United States
Fridley, Minnesota, United States
Cape Girardeau, Missouri, United States
Warren, Ohio, United States
Fort Eisenhower, Georgia, United States
Burlington, Massachusetts, United States
Tawas City, Michigan, United States
Jacksonville, North Carolina, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Grove City, Ohio, United States
Independence, Ohio, United States
Kettering, Ohio, United States
Oklahoma City, Oklahoma, United States
Panorama City, California, United States
Beaver, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Philadelphia, Pennsylvania, United States
Wexford, Pennsylvania, United States
Oconto Falls, Wisconsin, United States
Sanford, Maine, United States
La Jolla, California, United States
San Diego, California, United States
Walnut Creek, California, United States
Walnut Creek, California, United States
Brighton, Colorado, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
Similar Trials