Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease
Launched by NRG ONCOLOGY · Dec 13, 2021
Trial Information
Current as of August 22, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial, titled "Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease," is looking at how to best choose chemotherapy treatments for patients with Stage III colon cancer after their surgery. The researchers want to see if the presence of a specific type of tumor DNA in the blood, called circulating tumor DNA (ctDNA), can help guide the decision on which chemotherapy drugs to use. This study is currently recruiting participants who are between 65 to 74 years old, and it is open to all genders.
To be eligible for the trial, patients must have had successful surgery to remove their colon cancer and should not have any signs of cancer spread to other parts of the body. They should have a certain level of health as determined by their doctor. Participants will provide a blood sample for testing ctDNA after their surgery and may receive chemotherapy based on the results. It’s important for potential participants to know that this study may involve multiple treatment options and monitoring, which can help improve their chances of a successful recovery.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • The patient must have an ECOG performance status of 0 or 1.
- • Patients must have histologically/pathologically confirmed Stage IIB, IIC, or Stage III colon adenocarcinoma with R0 resection according to AJCC 8th edition criteria.
- • No radiographic evidence of overt metastatic disease within 45 days prior to Step 1/Study entry (CT with IV contrast or MRI imaging is acceptable and must include chest, abdomen, and pelvis).
- • The distal extent of the tumor must be greater than or equal to 12 cm from the anal verge on colonoscopy or above the peritoneal reflection as documented during surgery or on pathology specimen (i.e., excluding rectal adenocarcinomas warranting treatment with chemoradiation).
- • The patient must have had an en bloc complete gross resection of tumor (curative resection). Patients who have had a two-stage surgical procedure, to first provide a decompressive colostomy and then in a later procedure to have the definitive surgical resection, are eligible.
- • The resected tumor specimen and a blood specimen from patients with Stage IIB, IIC, or Stage III colon cancer must have central testing for ctDNA using the Signatera™ assay by Natera (after Step 1/Study entry and before Step2/Randomization). Patient must have sufficient tissue to meet protocol requirements. This blood specimen for the Signatera assay must be collected after surgery (and recommended at least 14 days post surgery).
- • Tumor must be documented as microsatellite stable or have intact mismatch repair proteins through CLIA-approved laboratory testing. Patients whose tumors are MSI-H or dMMR are excluded.
- • The treating investigator must deem the patient a candidate for all potential agents used in this trial (5FU, LV, oxaliplatin and irinotecan).
- • The interval between surgery (post-operative Day 7) and Step 1/Study entry must be no more than 60 days. NOTE: Step 1/Study Entry may occur as early as post operative Day 7, but it cannot occur beyond 60 days from the actual date of the patient's surgery.
- • Availability and provision of adequate surgical tumor tissue for molecular diagnostics and confirmatory profiling.
- Adequate hematologic function within 28 days before Step 1/Study entry defined as follows:
- • Absolute neutrophil count (ANC) must be greater than or equal to 1500/mm3;
- • Participants with benign ethnic neutropenia (BEN): ANC less than 1300 mm3 are eligible.
- • BEN (also known as constitutional neutropenia) is an inherited cause of mild or moderate neutropenia that is not associated with any increased risk for infections or other clinical manifestations. BEN is referred to as ethnic neutropenia because of its increased prevalence in people of African descent and other specific ethnic groups.
- • Platelet count must be greater than or equal to 100,000/mm3; and
- • Hemoglobin must be greater than or equal to 9 g/dL.
- Adequate hepatic function within 28 days before Step 1/Study entry defined as follows:
- • total bilirubin must be less than or equal to ULN (upper limit of normal) for the lab and
- • alkaline phosphatase must be less than 2.5 x ULN for the lab; and
- • AST and ALT must be less than 2.5 x ULN for the lab.
- • Adequate renal function within 28 days before Step 1/Study entry defined as serum creatinine less than or equal to 1.5 x ULN for the lab or measured or calculated creatinine clearance greater than or equal to 50 mL/min using the Cockroft-Gault formula for patients with creatinine levels greater than 1.5 x ULN for the lab.
- • For Women Creatinine Clearance (mL/min) = (140 - age) x weight (kg) x 0.85 72 x serum creatinine (mg/dL) For Men Creatinine Clearance (mL/min) = (140 - age) x weight (kg) 72 x serum creatinine (mg/dL) NOTE: Adjusted body weight (AdjBW) should be used for patients that have BMI greater than or equal to 28 (less than or equal to 30% above IBW).
- • HIV-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial.
- • Pregnancy test (urine or serum according to institutional standard) done within 14 days before Step 1/Study entry must be negative (for women of childbearing potential only).
- • Patients receiving a coumarin-derivative anticoagulant must agree to weekly monitoring of INR if they are randomized to Arm 1 or Arm 3 and receive capecitabine.
- • Eligibility Criteria for Cohort A Arm-2 patients on Second Randomization
- • Patient must have developed a ctDNA +ve assay during serial monitoring.
- • Patient's willingness to be re-randomized affirmed.
- • The patient must continue to have an ECOG performance status of 0 or 1.
- • No radiographic evidence of overt metastatic disease.
- • Pregnancy test (urine or serum according to institutional standard) done within 14 days before second randomization must be negative (for women of childbearing potential only).
- Adequate hematologic function within 28 days before second randomization defined as follows:
- • Absolute neutrophil count (ANC) must be greater than or equal to 1500/mm3;
- • Participants with benign ethnic neutropenia (BEN): ANC less than 1300 mm3 are eligible.
- • BEN (also known as constitutional neutropenia) is an inherited cause of mild or moderate neutropenia that is not associated with any increased risk for infections or other clinical manifestations. BEN is referred to as ethnic neutropenia because of its increased prevalence in people of African descent and other specific ethnic groups.
- • Platelet count must be greater than or equal to 100,000/mm3; and
- • Hemoglobin must be greater than or equal to 9 g/dL.
- Adequate hepatic function within 28 days before second randomization defined as follows:
- • total bilirubin must be less than or equal to ULN (upper limit of normal) for the lab and
- • alkaline phosphatase must be less than 2.5 x ULN for the lab; and
- • AST and ALT must be less than 2.5 x ULN for the lab.
- • Adequate renal function within 28 days before second randomization defined as serum creatinine less than or equal to 1.5 x ULN for the lab or measured or calculated creatinine clearance greater than or equal to 50 mL/min using the Cockroft-Gault formula for patients with creatinine levels greater than 1.5 x ULN for the lab.
- • For Women Creatinine Clearance (mL/min) = (140 - age) x weight (kg) x 0.85 72 x serum creatinine (mg/dL) For Men Creatinine Clearance (mL/min) = (140 - age) x weight (kg) 72 x serum creatinine (mg/dL)
- Exclusion Criteria:
- • Colon cancer histology other than adenocarcinoma (i.e., neuroendocrine carcinoma, sarcoma, lymphoma, squamous cell carcinoma, etc.).
- • Pathologic, clinical, or radiologic overt evidence of metastatic disease. This includes isolated, distant, or non-contiguous intra-abdominal metastases, even if resected.
- • Tumor-related bowel perforation.
- • History of prior invasive colon malignancy, regardless of disease-free interval.
- • History of bone marrow or solid organ transplantation (regardless of current immunosuppressive therapy needs). Bone grafts, skin grafts, corneal transplants and organ/tissue donation are not exclusionary.
- • Any prior systemic chemotherapy, targeted therapy, or immunotherapy; or radiation therapy administered as treatment for colorectal cancer (e.g., primary colon adenocarcinomas for which treatment with neoadjuvant chemotherapy and/or radiation is warranted are not permitted). EXCEPTION: one cycle of chemotherapy (regimen per treating physicians' discretion - 5-FU or capecitabine with or without oxaliplatin) is allowed but not required after consent. The optional cycle of chemotherapy should be started greater than or equal to 4 weeks from surgery and while awaiting Step 2 randomization.
- • Other invasive malignancy within 5 years before Step 1/Study entry. Exceptions are colonic polyps, non-melanoma skin cancer or any carcinoma-in-situ.
- • Synchronous primary rectal and/ or colon cancers.
- • Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better.
- • Sensory or motor neuropathy greater than or equal to grade 2, according to CTCAE v5.0.
- • Blood transfusion within two weeks before collection of blood for central ctDNA testing.
- • Active seizure disorder uncontrolled by medication.
- • Active or chronic infection requiring systemic therapy.
- • Known homozygous DPD (dihydropyrimidine dehydrogenase) deficiency.
- • Patients known to have Gilbert's Syndrome or homozygosity for UGT1A1\*28 polymorphism.
- • Pregnancy or lactation at the time of Step 1/Study entry.
- • Co-morbid illnesses or other concurrent disease that would make the patient inappropriate for entry into this study (i.e., unable to tolerate 6 months of combination chemotherapy or interfere significantly with the proper assessment of safety and toxicity of the prescribed regimens or prevent required follow-up).
- • Ineligibility Criteria for Cohort A Arm-2 patients on Second Randomization
- • Pregnancy or lactation at the time of randomization.
- • No longer a candidate for systemic chemotherapy (FOLFOX, CAPOX, and mFOLFIRINOX) in the opinion of the treating investigator.
About Nrg Oncology
NRG Oncology is a prominent clinical trial sponsor dedicated to advancing cancer research through innovative multi-institutional studies. Comprising a collaborative network of leading academic institutions and community hospitals, NRG Oncology focuses on enhancing patient outcomes by conducting rigorous clinical trials that evaluate new treatment strategies and improve existing therapies. With a commitment to scientific excellence and patient-centered care, the organization plays a vital role in shaping the future of oncology by integrating cutting-edge research with clinical practice, ultimately striving to translate findings into meaningful improvements in cancer care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
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Steubenville, Ohio, United States
Strongsville, Ohio, United States
Oregon City, Oregon, United States
Monroeville, Pennsylvania, United States
Natrona Heights, Pennsylvania, United States
Burien, Washington, United States
Edmonds, Washington, United States
Issaquah, Washington, United States
Eau Claire, Wisconsin, United States
New Richmond, Wisconsin, United States
Barrie, Ontario, Canada
Urbana, Illinois, United States
Springfield, Illinois, United States
Belpre, Ohio, United States
Columbus, Ohio, United States
Delaware, Ohio, United States
Lancaster, California, United States
Brooklyn, New York, United States
Longmont, Colorado, United States
Las Vegas, Nevada, United States
Mclean, Virginia, United States
Springfield, Ohio, United States
Saint Peters, Missouri, United States
Beaver, Pennsylvania, United States
Greensburg, Pennsylvania, United States
Johnstown, Pennsylvania, United States
Natrona Heights, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
Pittsburgh, Pennsylvania, United States
New York, New York, United States
Great Falls, Montana, United States
Loveland, Colorado, United States
Sugar Land, Texas, United States
Auburn, California, United States
Davis, California, United States
Santa Cruz, California, United States
Newark, Delaware, United States
Newark, Delaware, United States
Caldwell, Idaho, United States
Coeur D'alene, Idaho, United States
Sandpoint, Idaho, United States
Fort Wayne, Indiana, United States
Clive, Iowa, United States
West Des Moines, Iowa, United States
Garden City, Kansas, United States
Great Bend, Kansas, United States
Brighton, Michigan, United States
Canton, Michigan, United States
Caro, Michigan, United States
Chelsea, Michigan, United States
Clarkston, Michigan, United States
Clarkston, Michigan, United States
East China Township, Michigan, United States
Flint, Michigan, United States
Flint, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Macomb, Michigan, United States
Macomb, Michigan, United States
Marlette, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Pontiac, Michigan, United States
Saginaw, Michigan, United States
Sterling Heights, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
Warren, Michigan, United States
West Branch, Michigan, United States
Ypsilanti, Michigan, United States
Minneapolis, Minnesota, United States
Anaconda, Montana, United States
Henderson, Nevada, United States
Las Vegas, Nevada, United States
Las Vegas, Nevada, United States
Clinton, North Carolina, United States
Jacksonville, North Carolina, United States
Centerville, Ohio, United States
Dublin, Ohio, United States
Grove City, Ohio, United States
Marion, Ohio, United States
Wadsworth, Ohio, United States
West Chester, Ohio, United States
Ontario, Oregon, United States
Lewisburg, Pennsylvania, United States
South Jordan, Utah, United States
Colorado Springs, Colorado, United States
Durango, Colorado, United States
Durango, Colorado, United States
Creston, Iowa, United States
Bardstown, Kentucky, United States
Corbin, Kentucky, United States
Lexington, Kentucky, United States
Lexington, Kentucky, United States
Louisville, Kentucky, United States
Shepherdsville, Kentucky, United States
Flushing, New York, United States
Cincinnati, Ohio, United States
Cincinnati, Ohio, United States
Enumclaw, Washington, United States
Tacoma, Washington, United States
Berkeley Heights, New Jersey, United States
Carbondale, Illinois, United States
Carterville, Illinois, United States
Centralia, Illinois, United States
Danville, Illinois, United States
Decatur, Illinois, United States
Effingham, Illinois, United States
Mattoon, Illinois, United States
New Lenox, Illinois, United States
O'fallon, Illinois, United States
Yorkville, Illinois, United States
Louisville, Kentucky, United States
Marrero, Louisiana, United States
Brighton, Michigan, United States
Canton, Michigan, United States
Chelsea, Michigan, United States
Ypsilanti, Michigan, United States
Maple Grove, Minnesota, United States
Wyoming, Minnesota, United States
Sainte Genevieve, Missouri, United States
Sullivan, Missouri, United States
Sunset Hills, Missouri, United States
Centerville, Ohio, United States
Cincinnati, Ohio, United States
Dayton, Ohio, United States
Findlay, Ohio, United States
Findlay, Ohio, United States
Franklin, Ohio, United States
Greenville, Ohio, United States
Clackamas, Oregon, United States
Conroe, Texas, United States
Houston, Texas, United States
League City, Texas, United States
Sturgeon Bay, Wisconsin, United States
Dublin, California, United States
Lone Tree, Colorado, United States
Glenview, Illinois, United States
Highland Park, Illinois, United States
Ames, Iowa, United States
Boone, Iowa, United States
Fort Dodge, Iowa, United States
Jefferson, Iowa, United States
Marshalltown, Iowa, United States
Lutherville, Maryland, United States
Milford, Massachusetts, United States
Richmond, Virginia, United States
Bakersfield, California, United States
Dublin, California, United States
Sacramento, California, United States
San Rafael, California, United States
Walnut Creek, California, United States
Baton Rouge, Louisiana, United States
Baton Rouge, Louisiana, United States
Westminster, Maryland, United States
South Weymouth, Massachusetts, United States
Norton Shores, Michigan, United States
Novi, Michigan, United States
Monticello, Minnesota, United States
Columbus, Mississippi, United States
Grenada, Mississippi, United States
New Albany, Mississippi, United States
Oxford, Mississippi, United States
Southhaven, Mississippi, United States
Creve Coeur, Missouri, United States
Saint Louis, Missouri, United States
Carson City, Nevada, United States
Henderson, Nevada, United States
Mansfield, Ohio, United States
Medina, Ohio, United States
Ravenna, Ohio, United States
Lebanon, Pennsylvania, United States
Greer, South Carolina, United States
Riverton, Utah, United States
Eau Claire, Wisconsin, United States
Ladysmith, Wisconsin, United States
Aurora, Illinois, United States
Fremont, California, United States
London, Kentucky, United States
Wexford, Pennsylvania, United States
Farmington, Utah, United States
Milwaukee, Wisconsin, United States
Fountain Valley, California, United States
Washington, District Of Columbia, United States
Baltimore, Maryland, United States
Gaithersburg, Maryland, United States
Londonderry, New Hampshire, United States
Elizabeth, New Jersey, United States
Sewell, New Jersey, United States
Burke, Virginia, United States
Menomonee Falls, Wisconsin, United States
Mukwonago, Wisconsin, United States
West Bend, Wisconsin, United States
Carlisle, Pennsylvania, United States
Waukesha, Wisconsin, United States
Winchester, Massachusetts, United States
Ontario, California, United States
Trumbull, Connecticut, United States
Louisville, Kentucky, United States
South Portland, Maine, United States
Gahanna, Ohio, United States
Westlake, Ohio, United States
Phoenix, Arizona, United States
Pittsburgh, Pennsylvania, United States
Orland Park, Illinois, United States
Plainfield, Illinois, United States
Glen Burnie, Maryland, United States
Charlotte, North Carolina, United States
Jefferson Hills, Pennsylvania, United States
Phoenix, Arizona, United States
Elk Grove, California, United States
Rocklin, California, United States
Sacramento, California, United States
San Luis Obispo, California, United States
Santa Maria, California, United States
Woodland, California, United States
Sanford, Maine, United States
Tawas City, Michigan, United States
Las Vegas, Nevada, United States
Lakewood, New Jersey, United States
Rio Rancho, New Mexico, United States
Perrysburg, Ohio, United States
Willow Grove, Pennsylvania, United States
Las Cruces, New Mexico, United States
Warrensville Heights, Ohio, United States
Seattle, Washington, United States
Fort Worth, Texas, United States
Derby, Connecticut, United States
Fairfield, Connecticut, United States
Guilford, Connecticut, United States
North Haven, Connecticut, United States
Orange, Connecticut, United States
Waterbury, Connecticut, United States
Waterford, Connecticut, United States
Milford, Delaware, United States
Dekalb, Illinois, United States
Cape May Court House, New Jersey, United States
Charlotte, North Carolina, United States
Charlotte, North Carolina, United States
Charlotte, North Carolina, United States
Beavercreek, Ohio, United States
Virginia Beach, Virginia, United States
Martinsburg, West Virginia, United States
Stevens Point, Wisconsin, United States
York, Pennsylvania, United States
Arroyo Grande, California, United States
Greenwich, Connecticut, United States
New Haven, Connecticut, United States
Baton Rouge, Louisiana, United States
Deer River, Minnesota, United States
Hibbing, Minnesota, United States
Sandstone, Minnesota, United States
Virginia, Minnesota, United States
Hazleton, Pennsylvania, United States
Collierville, Tennessee, United States
Germantown, Tennessee, United States
Ashland, Wisconsin, United States
Medford, Wisconsin, United States
Colorado Springs, Colorado, United States
Honolulu, Hawaii, United States
Ballwin, Missouri, United States
Washington, Missouri, United States
Jersey City, New Jersey, United States
Newport Beach, California, United States
Golden, Colorado, United States
Worthington, Minnesota, United States
Saint Catharines, Ontario, Canada
Farrell, Pennsylvania, United States
'Aiea, Hawaii, United States
Lake Forest, Illinois, United States
Biddeford, Maine, United States
Sanford, Maine, United States
Detroit Lakes, Minnesota, United States
Cary, North Carolina, United States
Garner, North Carolina, United States
Altoona, Pennsylvania, United States
Mechanicsburg, Pennsylvania, United States
Oak Creek, Wisconsin, United States
Tampa, Florida, United States
Springfield, Ohio, United States
Libertyville, Illinois, United States
Kingman, Arizona, United States
Dixon, Illinois, United States
Washington, Illinois, United States
Farmington, Missouri, United States
Redwood City, California, United States
San Mateo, California, United States
Upland, California, United States
Colorado Springs, Colorado, United States
Fort Collins, Colorado, United States
Greeley, Colorado, United States
Tampa, Florida, United States
Peabody, Massachusetts, United States
Burnsville, Minnesota, United States
York, Pennsylvania, United States
Bozeman, Montana, United States
Alliance, Ohio, United States
Golden, Colorado, United States
Baton Rouge, Louisiana, United States
Duluth, Georgia, United States
Covington, Louisiana, United States
Cambridge, Minnesota, United States
Princeton, Minnesota, United States
Carmichael, California, United States
Irvine, California, United States
Stamford, Connecticut, United States
'Ewa Beach, Hawaii, United States
Barrington, Illinois, United States
Crystal Lake, Illinois, United States
Crown Point, Indiana, United States
Dyer, Indiana, United States
Hobart, Indiana, United States
Hobart, Indiana, United States
Indianapolis, Indiana, United States
Munster, Indiana, United States
Valparaiso, Indiana, United States
Kalamazoo, Michigan, United States
Moose Lake, Minnesota, United States
Thief River Falls, Minnesota, United States
Sleepy Hollow, New York, United States
Dublin, Ohio, United States
Butler, Pennsylvania, United States
Camp Hill, Pennsylvania, United States
Chambersburg, Pennsylvania, United States
Cranberry Township, Pennsylvania, United States
Indiana, Pennsylvania, United States
Monroeville, Pennsylvania, United States
N. Huntingdon, Pennsylvania, United States
New Castle, Pennsylvania, United States
Uniontown, Pennsylvania, United States
Washington, Pennsylvania, United States
Williamsport, Pennsylvania, United States
Richardson, Texas, United States
Cudahy, Wisconsin, United States
Frederick, Maryland, United States
Fresh Meadows, New York, United States
Newnan, Georgia, United States
Glastonbury, Connecticut, United States
Neenah, Wisconsin, United States
Shawano, Wisconsin, United States
Waupaca, Wisconsin, United States
New York, New York, United States
Lancaster, Pennsylvania, United States
Westerly, Rhode Island, United States
Louisville, Kentucky, United States
Cary, North Carolina, United States
Highlands Ranch, Colorado, United States
Raleigh, North Carolina, United States
Missoula, Montana, United States
Torrance, California, United States
Lone Tree, Colorado, United States
Greenlawn, New York, United States
Oshkosh, Wisconsin, United States
Edinburg, Texas, United States
Chesapeake, Virginia, United States
Suffolk, Virginia, United States
Pierre, South Dakota, United States
Cary, North Carolina, United States
Newnan, Georgia, United States
Stockbridge, Georgia, United States
Torrance, California, United States
'Aiea, Hawaii, United States
Alton, Illinois, United States
Springfield, Illinois, United States
Grand Island, Nebraska, United States
Perrysburg, Ohio, United States
Toledo, Ohio, United States
Toledo, Ohio, United States
Denver, Colorado, United States
Prince George, British Columbia, Canada
Philadelphia, Pennsylvania, United States
Aurora, Colorado, United States
Shiloh, Illinois, United States
Yankton, South Dakota, United States
Berlin, Wisconsin, United States
Laguna Hills, California, United States
Mineola, New York, United States
Raleigh, North Carolina, United States
Pittsburgh, Pennsylvania, United States
Seattle, Washington, United States
Avon, Ohio, United States
Cumberland, Maryland, United States
Bellevue, Washington, United States
Des Moines, Iowa, United States
Kalispell, Montana, United States
Los Angeles, California, United States
Dallas, Texas, United States
Rochester, New York, United States
Lebanon, New Hampshire, United States
Moon, Pennsylvania, United States
Cameron Park, California, United States
Sheboygan, Wisconsin, United States
Wyoming, Michigan, United States
Grand Rapids, Michigan, United States
Muskegon, Michigan, United States
Troy, Ohio, United States
Nampa, Idaho, United States
Pontiac, Michigan, United States
Ann Arbor, Michigan, United States
Brighton, Michigan, United States
Chelsea, Michigan, United States
Foxboro, Massachusetts, United States
Dayton, Ohio, United States
Webster, New York, United States
Neillsville, Wisconsin, United States
Danville, Illinois, United States
New Albany, Ohio, United States
Guilford, Connecticut, United States
Orland Park, Illinois, United States
Greenville, Ohio, United States
Boone, Iowa, United States
Fort Dodge, Iowa, United States
Jefferson, Iowa, United States
Marshalltown, Iowa, United States
Los Angeles, California, United States
Ames, Iowa, United States
Canton, Michigan, United States
Rhinelander, Wisconsin, United States
Stevens Point, Wisconsin, United States
Ladysmith, Wisconsin, United States
Minocqua, Wisconsin, United States
Columbia, Missouri, United States
Florham Park, New Jersey, United States
Los Angeles, California, United States
Glenview, Illinois, United States
Grayslake, Illinois, United States
Ankeny, Iowa, United States
Rego Park, New York, United States
Sunset Hills, Missouri, United States
Dillon, Colorado, United States
Reed City, Michigan, United States
Saint Joseph, Michigan, United States
Aberdeen, Maryland, United States
Des Moines, Iowa, United States
Clive, Iowa, United States
Woodbridge, Virginia, United States
Lincoln, Nebraska, United States
Lansing, Michigan, United States
Carmichael, California, United States
Richmond, Virginia, United States
Grand Rapids, Michigan, United States
Rockford, Illinois, United States
Escanaba, Michigan, United States
Jefferson City, Missouri, United States
Pontiac, Michigan, United States
Madison, Wisconsin, United States
Lynchburg, Virginia, United States
Kirkland, Washington, United States
Silverdale, Washington, United States
Saint Johnsbury, Vermont, United States
Dayton, Ohio, United States
Dayton, Ohio, United States
Johnson Creek, Wisconsin, United States
Royal Oak, Michigan, United States
Johnson Creek, Wisconsin, United States
Sandpoint, Idaho, United States
Ontario, Oregon, United States
Walnut Creek, California, United States
Irvine, California, United States
Dearborn, Michigan, United States
Troy, Michigan, United States
Fort Eisenhower, Georgia, United States
Lexington, Kentucky, United States
Mitchell, South Dakota, United States
Saginaw, Michigan, United States
Tawas City, Michigan, United States
Lake Mary, Florida, United States
Santa Cruz, California, United States
Golden, Colorado, United States
Southfield, Michigan, United States
Novi, Michigan, United States
Madison, Wisconsin, United States
Detroit, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Grosse Pointe Woods, Michigan, United States
Macomb, Michigan, United States
Warren, Michigan, United States
Aurora, Illinois, United States
Brighton, Colorado, United States
Flint, Michigan, United States
Warren, Michigan, United States
East China Township, Michigan, United States
Macomb, Michigan, United States
Warren, Michigan, United States
Harbor City, California, United States
Calgary, Alberta, Canada
Denver, Colorado, United States
Grosse Pointe Woods, Michigan, United States
Mount Vernon, Illinois, United States
Ankeny, Iowa, United States
Clive, Iowa, United States
Des Moines, Iowa, United States
Des Moines, Iowa, United States
Denver, Colorado, United States
Sheboygan, Wisconsin, United States
Calgary, Alberta, Canada
Waukee, Iowa, United States
Rolla, Missouri, United States
Raleigh, North Carolina, United States
Littleton, Colorado, United States
Parker, Colorado, United States
Cape Girardeau, Missouri, United States
Union, South Carolina, United States
Winchester, Massachusetts, United States
Biddeford, Maine, United States
Sanford, Maine, United States
South Portland, Maine, United States
Cherry Hill, New Jersey, United States
Kitchener, Ontario, Canada
Brighton, Massachusetts, United States
Phoenixville, Pennsylvania, United States
Ballwin, Missouri, United States
Saint Louis, Missouri, United States
Kalamazoo, Michigan, United States
Patients applied
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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