Addition of FFRct in the Diagnostic Pathway of Patients With Stable Chest Pain

Launched by ERASMUS MEDICAL CENTER · Dec 13, 2021

Keywords

ClinConnect Summary

This clinical trial is studying a new technique called Fractional Flow Reserve from coronary computed tomography (FFRct) to see if it can help doctors better understand if the blockages found in the coronary arteries are actually causing problems for patients with stable chest pain. Currently, when patients have chest pain, they often undergo a test called Coronary Computed Tomography Angiography (CCTA) to check for blockages. However, finding a blockage doesn't always mean it is serious enough to require treatment. FFRct is a non-invasive method that uses the same images from the CCTA to provide additional information about how significant those blockages are, potentially reducing the need for follow-up invasive tests.

To be eligible for this trial, participants must be at least 18 years old, have stable chest pain, and have already undergone a CCTA that showed a blockage of 50% to 90% in a major coronary artery. Participants can expect to receive the FFRct analysis as part of their care, which could help them and their doctors make better decisions about any necessary treatments. It's important to note that individuals with unstable chest pain, serious health issues, or certain previous medical procedures may not qualify for the study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • Stable chest pain and the patient underwent CCTA which demonstrated ≥50% but less than 90% stenosis in any major epicardial vessel with a diameter ≥ 2 mm.
• Exclusion Criteria:
• • Inability to provide informed consent
• • Unstable angina according to ESC guidelines
• • Unstable clinical status
• • Expected inability to complete follow-up and comply with follow-up aspects of the protocol
• • History of coronary revascularisation
• • Non-invasive or invasive diagnostic testing for CAD within the past 12 months (with the exception of exercise ECG)
• • Unsuitable for revascularisation if required (for example due to comorbidities or anatomical features)
• • Poor CT quality with expected inability to perform FFRct analysis