Vitamin D to Improve Quadricep Muscle Strength

Launched by CHINESE UNIVERSITY OF HONG KONG · Dec 14, 2021

Keywords

ClinConnect Summary

This clinical trial is studying whether vitamin D supplements can help improve muscle strength in people who have had surgery for an anterior cruciate ligament (ACL) injury. After ACL reconstruction, many patients experience a decrease in the strength of their quadriceps muscle, which is crucial for getting back to sports and daily activities. The researchers want to find out if taking vitamin D can help these patients regain muscle strength and overcome any vitamin D deficiency, which is common among athletes.

To participate in the trial, you must be between 18 and 40 years old, have had a single ACL injury, and still have low vitamin D levels even four months after your surgery. Additionally, your quadriceps strength should be less than 70% compared to the other leg. If you join the trial, you will receive either vitamin D supplements or a placebo (a non-active pill), and your muscle strength will be monitored to see if the vitamin D helps. It's important to note that this study is looking for ways to help patients recover better after ACL surgery and possibly prevent long-term muscle weakness.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Aged 18-40 with unilateral ACL injury
• • 2. Sporting injury with a Tegner score of 7
• • 3. Pre-op serum vitamin D level \<20 ng/ml
• • 4. 4 months post-ACLR with serum Vitamin D level remained \<20ng/ml
• • 5. LSI for quadriceps strength \<70% of contralateral leg at 4-month isokinetic assessment
• • 6. Both knees without history of injury/prior surgery
• Exclusion Criteria:
• • 1. Concomitant bone fracture, major meniscus injury or full-thickness chondral injuries requiring altered rehabilitation program post-operatively
• • 2. Pre-operative radiographic signs of arthritis
• • 3. Metal implants that would cause interference on MRI
• • 4. Non-HS graft for ACLR
• • 5. Patient non-compliant to the rehabilitation program
• • 6. Regular sunbed users