Imaging the Interplay Between Axonal Damage and Repair in Multiple Sclerosis
Launched by UNIVERSITY HOSPITAL, BASEL, SWITZERLAND · Dec 15, 2021
Trial Information
Current as of July 25, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is investigating how nerve damage and repair processes work in different types of Multiple Sclerosis (MS). The researchers aim to understand the differences in the health of nerve fibers between patients with active relapsing-remitting MS and those with non-active progressive MS. They will use advanced imaging techniques over two years to track changes and validate their findings with tissue samples.
To participate, patients must be between 18 and 80 years old and have a confirmed diagnosis of either active relapsing-remitting MS with recent relapses or non-active progressive MS without recent relapses. Healthy volunteers in the same age range can also join the study, as long as they do not have any neurological or psychiatric disorders. Participants will undergo imaging scans and may be asked questions about their health. It’s important to note that individuals who are pregnant, have certain medical devices, or cannot undergo MRI scans cannot participate. This study is currently recruiting participants, and your involvement could help improve our understanding of MS and how to better treat it.
Gender
ALL
Eligibility criteria
- Inclusion Criteria for patients:
- * Patients may be diagnosed with:
- • 1. active RRMS (n=100): Relapsing-remitting course and \> 1 clinical relapse and/or signs of MRI activity (\> 1 Gd enhancing lesion) during the last year before study enrollment.
- • 2. non-active PMS (n=100): Progressive course (PPMS or SPMS) and no clinical relapses and/or signs of MRI activity during the last year before study enrollment.
- • Age 18-80 years old
- • No other neurological or psychiatric disorder
- Inclusion criteria for healthy controls:
- • Age 18-80 years old
- • No other neurological or psychiatric disorder
- Exclusion Criteria for patients and healthy controls:
- • Pregnancy
- • Contraindication to MRI (eg, claustrophobia, metallic implants, pacemaker etc).
- • Inability to give consent
About University Hospital, Basel, Switzerland
The University Hospital Basel, Switzerland, is a leading academic medical center renowned for its commitment to cutting-edge research and innovative patient care. As a prominent clinical trial sponsor, the hospital leverages its extensive expertise and state-of-the-art facilities to advance medical knowledge and therapeutic options across various disciplines. With a collaborative approach that integrates clinical practice and scientific inquiry, the University Hospital Basel fosters an environment conducive to rigorous clinical trials, ensuring the highest standards of safety and efficacy. Its strategic focus on patient-centered research aims to translate scientific discoveries into tangible health solutions, benefiting both local and global communities.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Basel, , Switzerland
Patients applied
Trial Officials
Cristina Granziera, Prof. Dr. med.
Principal Investigator
Department of Neurology, University Hospital Basel
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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