Peginterferon Treatment Study for Inactive Chronic Hepatitis B Patients
Launched by THIRD AFFILIATED HOSPITAL, SUN YAT-SEN UNIVERSITY · Jan 6, 2022
Trial Information
Current as of May 30, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is studying the effects of a treatment called peginterferon on patients with inactive chronic hepatitis B, a condition where the virus is present but not actively damaging the liver. The goal is to find out how effective this treatment is and to identify factors that might help achieve a "functional cure," which means the virus could be controlled without ongoing treatment. Researchers are particularly interested in understanding how different treatment plans may work for these patients.
To participate in the trial, potential volunteers should be between 18 and 60 years old, have been living with hepatitis B for more than six months, and meet specific health criteria, such as having normal liver enzyme levels and not having used antiviral medications before. Participants will be monitored closely throughout the study, which aims to provide insights into how best to manage this condition. If you're considering joining, it's important to know that the study excludes individuals with certain health issues, including liver cirrhosis or serious organ problems.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age 18-60, no gender limitation
- • HBsAg is positive for more than 6 months
- • Hepatitis B e antigen(HBeAg) is negative and anti-HBe is positive
- • Serum HBV DNA is less than 2000 IU/mL
- • Alanine aminotransferase(ALT) and/or Aspartate aminotransferase(AST) is normal
- • No antiviral durg (including nucleos(t)ide analogue and interferon) was used before enrollment
- • Good compliance and voluntarily signed informed consent
- Exclusion Criteria:
- • Allergic to pegylated interferon α-2b
- • Any indication of liver cirrhosis
- • Coinfection with hepatitis A virus(HAV), hepatitis C virus(HCV), hepatitis D virus(HDV), hepatitis E virus(HEV) or human immunodeficiency virus(HIV)
- • Combined with other liver diseases (including drug-related, alcoholic, autoimmune, genetic metabolic liver diseases, etc.)
- • There are serious lesions in the important organs, such as heart, lung, kidney, brain and fundus
- • Patients with autoimmune diseases, unstable diabetes or thyroid diseases(hyperthyroidism or hypothyroidism)
- • Confirmed or suspected liver cancer or other malignant tumors
- • Patients after or preparing for organ transplantation
- • Peripheral blood white blood cell count \< 3.5×109/L and/or platelet count \< 80×109/L
- • Under immunosuppressant treatment
- • Pregnant or planned pregnancy in a short term or lactation patients
- • Alcohol abuse (average alcohol intake is more than 40 g/d in males or 20g/d in women) or drug addicts
- • Present or past history of mental or psychological diseases
- • Other conditions that the investigators deem inappropriate for the study.
About Third Affiliated Hospital, Sun Yat Sen University
The Third Affiliated Hospital of Sun Yat-sen University is a leading medical institution in China, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a prominent sponsor of clinical trials, the hospital leverages its comprehensive resources and multidisciplinary expertise to facilitate cutting-edge studies that aim to improve patient outcomes and contribute to the global body of medical knowledge. With a focus on collaboration and patient-centered care, the Third Affiliated Hospital is dedicated to fostering advancements in medical science and ensuring the highest standards of ethical practice in clinical research.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Guangzhou, Guangdong, China
Patients applied
Trial Officials
Zhiliang Gao, Doctor
Study Chair
Third Affiliated Hospital, Sun Yat-Sen University
Guizhou Zou
Principal Investigator
The Second Hospital of Anhui Medical University
Jiabin Li
Principal Investigator
The First Affiliated Hospital of Anhui Medical University
Zhende Lin
Principal Investigator
Anxi County Hospital
Guoxin Hu
Principal Investigator
SHENZHEN HOSPITAL of PEKING UNIVERSITY
Youping Lin
Principal Investigator
Dongguan Binhai Bay Central Hospital
Sichun Yin
Principal Investigator
Dongguan Ninth People's Hospital
Songmei He
Principal Investigator
Dongguan People's Hospital
Zengjia Xu
Principal Investigator
Dongyuan People's Hospital
Hui Shen
Principal Investigator
DuShanZi People's Hospital
Haifei Luo
Principal Investigator
First People's Hospital of Foshan
Wenhua Zhang
Principal Investigator
Gansu Wuwei Tumor Hospital
Maosheng Wu
Principal Investigator
Guangdong Second Provincial People's Hospital
Dong Wei
Principal Investigator
Guangzhou Second traditional Chinese Medicine hospital
Wenli Chen
Principal Investigator
Guangdong Provincial People's Hospital
Bihua Gao
Principal Investigator
Beihai People's hospital
Guifang Tang
Principal Investigator
Nanxishan Hospital of Giang xi zhuang Autonomous Region
Huaiyu Song
Principal Investigator
THE PEOPLE'S HOSPITAL OF GUANGXI ZHUANG AUTCNOMOUS REGION
Zhuxiang Zhao
Principal Investigator
The First Municipal Hospital of Guangzhou
Xihua Fu
Principal Investigator
Guangzhou Panyu Central Hospital
Runqi Luo
Principal Investigator
Second Affiliated Hospital of Guangzhou Medical University
Shi Ouyang
Principal Investigator
Fifth Affiliated Hospital of Guangzhou Medical University
Chunlan Zhang
Principal Investigator
GUANGZHOU EIGHTH PEOPLE'S HOSPITAL GUANGZHOU MEDICAL UNIVERSITY
Riying Lv
Principal Investigator
Guigang city People's Hospital
Bigang Xiong
Principal Investigator
GuiYang Public Health Clinlcal Center
Hong Peng
Principal Investigator
the People's Hospital of Guizhou
Sufen Zhou
Principal Investigator
The First Affiliated Hospital of Guizhou University of traditional Chinese Medicine
Quan Zhang
Principal Investigator
The Affiliated Hospital Of Guizhou Medical University
YongChao Xian
Principal Investigator
The Third People's Hospital of Guilin
Ganwen Li
Principal Investigator
The Third Affiliated Hospital of Sun Yat-Sen Unlversity Yuedong hospital
Jinyu Xia
Principal Investigator
The Fifth Affiliated Hospital, Sun Yat-sen University
Bihui Zhong
Principal Investigator
The First Afiliated Hospital Sun Yat-sen University
Minhui Xiao
Principal Investigator
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Wenjun Gao
Principal Investigator
Zhongshan Sencond People's Hospital
Gang Li
Principal Investigator
The fourth people's Hospital of Zibo
Yangwen Luo
Principal Investigator
Zunyi Medical College
Jie Chen
Principal Investigator
The Second People's Hospital OF YULIN
Xiaochao Qin
Principal Investigator
Red Cross Hospital of Yulin City
Wuhai Qin
Principal Investigator
teaditional chinese medicine hospital of YULIN
Hongshun Fan
Principal Investigator
Yuebei Second People's Hospital
Ming Jiang
Principal Investigator
Guilin Municipal Hospital of Traditonal
Feng Lin
Principal Investigator
HANNAN GENERAL HOSPITAL
Chengfang Zheng
Principal Investigator
Hainan Western Central Hospital
Zhentao Gu
Principal Investigator
Heyuan people's Hospital
Fan Li
Principal Investigator
THE PEOPLE'S HOSPITAL of HEZHOU
Qin Yan
Principal Investigator
Huazhong University of Science and Technology Union Shenzhen Hospital
Zhanzhou Lin
Principal Investigator
Huizhou Municipal Central Hospital
Hui Chen
Principal Investigator
Hepatobiliary Hospital Of JiLin
Xujing Liang
Principal Investigator
First Affiliated Hospital of Jinan University
Bin Liu
Principal Investigator
The Affiliated Shunde Hospital of Jinan University
Changzheng Hu
Principal Investigator
Jiangmen Central Hospital
Xingchuan Wang
Principal Investigator
The 924th Hospital of the PLA joint Logistic support Force
Chengzu Lin
Principal Investigator
Jinjiang City Hospital
Guihua Su
Principal Investigator
the First People's Hopistal of Kashi
Yi Wang
Principal Investigator
Karamay Central Hospital of Xinjiang
Yuqin Xu
Principal Investigator
The 962th Hospital of the PLA joint Logistic support Force
Lingyi Zhang
Principal Investigator
Lanzhou University Second Hospital
Xiaorong Mao
Principal Investigator
LanZhou University
Hong Wan
Principal Investigator
Lanzhou University Second Hospital
Qian Guo
Principal Investigator
LIU ZHOU WORKER'S HOSPITAL
Liu He
Principal Investigator
LIU ZHOU PEOPLE'S HOSPITAL
Zhengxiao Zhao
Principal Investigator
LIU ZHOU TRADITIONAL CHINESE MEDICAL HOSPITAL
Yan Lincan
Principal Investigator
Long yan hospital of traditional Chinese medicine
Feng Min
Principal Investigator
army 73rd group military hospital
Xiqiu Zeng
Principal Investigator
Mudanjiang Kangan Hospital
Shuilin Sun
Principal Investigator
Second Affiliated Hospital of Nanchang University
Xiaoping Wu
Principal Investigator
The First Affiliated Hospital of Nanchang University
Keqin Zhang
Principal Investigator
The Ninth Hospital of Nanchang
Hong Li
Principal Investigator
Southern Medical University, China
Jianzhen Yao
Principal Investigator
Putian Hanjiang Hospital
Liqin Cai
Principal Investigator
The First Hospital of Putian City
Rongxian Qiu
Principal Investigator
The Affiliated Hospital of Putian University
Sandu Liu
Principal Investigator
The People's Hospital Of QianNan
Qinghua Lu
Principal Investigator
The Fourth People's Hospital of Qinghai Province
Ying Deng
Principal Investigator
The Sixth Affiliated Hospital of Guangzhou Medical University
Xingnan Pan
Principal Investigator
Quanzhou Decheng hospital
Ruyi Guo
Principal Investigator
Quanzhou First Hospital
Wenke Li
Principal Investigator
Quanzhou Hospital of traditional Chinese Medicine
Huiwen Song
Principal Investigator
SanMing First Hospital
Xiulan Xue
Principal Investigator
The First Affiliated Hospital of Xiamen University
Qianguo Mao
Principal Investigator
Xiamen Hospital of Traditional Chinese Medicine
Haidong Zhao
Principal Investigator
Xiamen Chang gung hospital
Yanhui Zu
Principal Investigator
Shan dong public Health Clinical Center
Ruilie Chen
Principal Investigator
Shantou Central Hospital
Shu Yang
Principal Investigator
Shenzhen Bao'an People's Hospital
Jun Chen
Principal Investigator
Shenzhen Third People's Hospital
Yanyao Yin
Principal Investigator
Shenzhen Luohu Hospitai of Traditional Chinese Medicine
Rongshan Fan
Principal Investigator
Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine
Guangdong Tong
Principal Investigator
SHEN ZHEN TRADITIONAL CHINESE MEDICINE HOSPITAL
Weize Zuo
Principal Investigator
The First Affiliated Hospital of Shihezi University School of Medicine
Bin Zhou
Principal Investigator
Weihai Chest Hospital
Huanwei Zheng
Principal Investigator
Shijiazhuang Hospital of Traditional Chinese Medicine
Chuantiao Zhang
Principal Investigator
Shishi General Hospital
Qing Ye
Principal Investigator
Tianjin Third Central Hospital
Xin Chen
Principal Investigator
Tianjin First Hospital
Changxia Niu
Principal Investigator
Tianshui First people's hospital
Jiancheng Zhang
Principal Investigator
Tianshui traditional Chinese medicine hospital
Ruihai Zhu
Principal Investigator
Weifang People's Hospital
Zhushi Liang
Principal Investigator
The Third People's Hospital of Wuzhou
Qingming Zheng
Principal Investigator
Fujian Xianyou General Hospital
Xiaobo Lu
Principal Investigator
First Affiliated Hospital of Xinjiang Medical University
Xiaozhong Wang
Principal Investigator
Traditional Chinese Medicine Hospital of Xinjiang
Huanwen Chen
Principal Investigator
XING AN COUNTY PEOPLE'S HOSPITSL
Haifeng Yu
Principal Investigator
YANTAI QISHAN HOSPITAL
Shengtao Zeng
Principal Investigator
Yili Prefecture Infectious Disease Hospital
Lei Li
Principal Investigator
Anhui Provincial Hospital
Weibing Shi
Principal Investigator
The First Affiliated Hospital of Anhui University of Chinese Medicine
Chuanmiao Liu
Principal Investigator
The First Affiliated Hospital of Bengbu Medical University
Mei Cai
Principal Investigator
Cangzhou Third Hospital
Lijuan Guan
Principal Investigator
The 2nd Hospital of da qing City
Riwang Hu
Principal Investigator
The 4th People's Hospital of da tong city
Jianli Huang
Principal Investigator
Yongchun County Hospital
Yueyong Zhu
Principal Investigator
First Affiliated Hospital of Fujian Medical University
Minghua Lin
Principal Investigator
Mengchao Hepatobiliary Hospital of Hujian Medical University
Ming Li
Principal Investigator
No.2 People's Hospital of Fuyang City
Xianqiu Huang
Principal Investigator
Guidong People's Hospital of Guangxi Zhuang Autonomous Region
Liying Zhu
Principal Investigator
The Second Affiliated Hospital of Harbin Medical University
Lei Yu
Principal Investigator
The Fourth Affiliated Hospital of Harbin Medical University
Baoshan Yang
Principal Investigator
First Affiliated Hospital of Harbin Medical University
Yuguo Zhang
Principal Investigator
The First Hospital of Hebei Medical University
Xiaoli Hu
Principal Investigator
Heilongjiang provincial hospital
Weizhong Yan
Principal Investigator
Jilin Central General Hospital
Xinsheng Xie
Principal Investigator
Affiliated Hospital of Jiaxing University
Caihua Jiang
Principal Investigator
FUJIAN JIANOU HOSPITAL
Guoqi Hu
Principal Investigator
Jieshou City People's Hospital
Junmei Han
Principal Investigator
THE THIRD HOSPITAL OF JIN CHENG
Deshun Yu
Principal Investigator
JIN CHENG PEOPLE'S HOSPITAL
Jianqi Lian
Principal Investigator
Tang-Du Hospital
Jiuping Wang
Principal Investigator
Xijing Hospital
Zhengjun Xu
Principal Investigator
The 910th Hospital
Fenxiang Li
Principal Investigator
LIN FEN THIRD PEOPLE'S HOSPITAL
Tonghe Wu
Principal Investigator
THE SECOND HOSPITAL OF LONGYAN
Fen Wu
Principal Investigator
JIANYANG FIRST HOSPITAL OF NANPING
Yun Wu
Principal Investigator
The Affiliated Hospital of Inner Mongolia Medical University
Houxiong Lin
Principal Investigator
Ningde Municipal Hospital of Ningde Normal University
Yongyue Deng
Principal Investigator
Zhongshan Hospital Xiamen University
Xiao Wang
Principal Investigator
Digestive Diseases Hospital of Shandong First Medical University
Huaizhang Li
Principal Investigator
Shanxi Traditional Chinese Medical Hospital
Liaoyun Zhang
Principal Investigator
The First Affiliated Hospital of Shanxi Medical University
Binhong Fu
Principal Investigator
Shaowu Municiple Hospital of Fujian Province
Ye Gu
Principal Investigator
The Sixth People's Hospital of Shenyang
Ying Guo
Principal Investigator
The Third People's Hospital of Taiyuan
Ping Li
Principal Investigator
Tianjin Second People's Hospital
Zhifeng Li
Principal Investigator
TONG LIAO INFECTIOUS DISEASES HOSPITAL
Jingning Zhao
Principal Investigator
SINOPHARM TONGMEI GENERAL HOSPITAL
Shuangsuo Dang
Principal Investigator
The Second Affiliated Hospital of Ｘi'an Jiaotong University
Shumei Lin
Principal Investigator
The First Affiliated Hospital of Ｘi'an Jiaotong University
Hongxin Pu
Principal Investigator
Yanbian University Hospital
Li Zhang
Principal Investigator
The Sixth hospital of Handan City
Yongmei Lin
Principal Investigator
Hanzhong 3201 Hospital
Chunzhi Su
Principal Investigator
Hebei Hospital of Traditional Chinese Medicine
Mingxia Jiang
Principal Investigator
Jiamusi Infectious Disease Hospital
Chengrun Xu
Principal Investigator
Southeast Hospital affiliated to Xiamen University
Ying Dai
Principal Investigator
The 7th Hospital of Qiqihar
Jiansheng Huang
Principal Investigator
Wuping County Hospital
Qingrui Peng
Principal Investigator
Xiapu County Hospital
Weixin Wang
Principal Investigator
The 2nd Affiliated Hospital of YCU
Zhigang Lin
Principal Investigator
SanMing Yongan General Hospital
Shihong Wu
Principal Investigator
Yuncheng Central Hospital
Zhongfu Zhao
Principal Investigator
Changzhi Medical College
Yi Zheng
Principal Investigator
Xinhua Hospital of Zhejiang Province
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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