Sleep and Circadian Mechanisms in Hypertension

Launched by OREGON HEALTH AND SCIENCE UNIVERSITY · Dec 22, 2021

Keywords

ClinConnect Summary

This clinical trial, titled "Sleep and Circadian Mechanisms in Hypertension," is exploring how our sleep patterns and body clocks affect blood pressure in people with high blood pressure, also known as hypertension. Researchers want to understand why some individuals experience higher blood pressure at night, a condition called non-dipping blood pressure. The study is currently looking for participants aged 25 to 64 who have a body mass index (BMI) between 18.5 and 42 and whose average resting blood pressure is between 130/80 mmHg and 160/100 mmHg.

If you qualify and decide to participate, you’ll be involved in research that aims to uncover important connections between sleep and blood pressure management. Certain factors may exclude you from taking part, such as recent smoking history, significant heart problems, or certain sleep disorders. Participants should not be currently pregnant or using illicit drugs. By joining this study, you can contribute to important discoveries that may help improve treatment for hypertension in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ages 25-64
• • BMI 18.5-42kg/m2
• • Hypertension (average resting blood pressure between 130/80 mmHg and 160/100 mmHg)
• Exclusion Criteria:
• • Over 5 pack-years of smoking;
• • Prior shift work within 12 months prior to the study;
• • Travel greater than three time zones for at least 3 months;
• • History of heart failure, cardiomyopathy, or history of bypass surgery, angioplasty, or previous myocardial infarction;
• • Acute or chronic diseases (except hypertension) that may affect outcome measures;
• • History of psychological conditions;
• • Sleep disorders, like severe sleep apnea, insomnia, etc.;
• • Prescription medications (Contraceptives and anti-hypertensive medications are permissible);
• • History of Illicit drug use and alcohol dependency;
• • 30 days free of cannabis use prior to the study;
• • Pregnancy;
• • Upper cut-off of 160/100 mmHg for BP