Cardiopulmonary Bypass Induced Red Blood Cell Lysis

Launched by UNIVERSITY OF MARYLAND, BALTIMORE · Jan 11, 2022

Keywords

ClinConnect Summary

This clinical trial is looking at how a medical procedure called cardiopulmonary bypass (CPB) can affect red blood cells during heart surgery. Researchers want to understand how CPB might cause damage to these cells and how it can lead to other problems, such as kidney injury. By studying the levels of certain proteins in the blood during and after the surgery, they hope to set safe limits for these proteins and find better ways to protect patients and detect potential issues early on.

To participate in this trial, you need to be between 18 and 75 years old and scheduled for a heart surgery that involves CPB for more than an hour, like complex cardiac surgery, heart valve replacement, or coronary artery bypass grafting (CABG). Participants will have blood tests to measure the proteins and other factors related to red blood cell damage. This study aims to improve care for patients undergoing heart surgery by finding ways to monitor and address risks associated with CPB.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Admitted to UMMC for cardiac procedure
• • Age: \>/=18 y.o TO 88 y.o.
• • Undergoing CPB \>1hr for the following surgeries (a) complex cardiac surgery (b) heart valve replacement surgery OR (c) CABG surgery.
• Exclusion Criteria:
• • Pregnant
• • Non English speaking
• • Unable to consent or have Legally Authorized Representative (LAR) assent to study