Can Waveform and Flow Traces From Mechanical Insuflattion:Exsufflation (MI:E) be Used to Identify Laryngeal Responses to MI:E and Thus Optimise Treatment Algorithms?

Launched by ROYAL FREE HOSPITAL NHS FOUNDATION TRUST · Jan 11, 2022

Keywords

ClinConnect Summary

This clinical trial is investigating how a device called a cough assist machine can help patients with neuromuscular diseases, such as Motor Neurone Disease, Multiple Sclerosis, and Muscular Dystrophy. The goal is to see if the machine's waveforms—patterns created during use—can help physiotherapists understand when a patient is having an unusual airway response during treatment. By doing this, the trial hopes to improve how cough assist devices are used, making them more effective for patients.

To participate in this trial, you must be at least 18 years old and have a neuromuscular disease. Participants will undergo some breathing tests to check their lung function and ensure they are eligible. If you join the study, you will use the cough assist device while a small camera looks at your voice box to see how your body is responding. This information will help physiotherapists provide better care for patients using cough assist devices. It’s an important step toward improving treatments for people with breathing difficulties related to their conditions.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with neuromuscular disease(NMD) including but not limited to Motor Neurone Disease (MND), Multiple Sclerosis (MS) and Muscular Dystrophy
• • Age ≥18
• Exclusion Criteria:
• • Unable to comply with protocol
• • Unable to give informed consent
• • Evidence of obstructive airways disease FEV1:FVC \<0.7
• * Patients with a history of:
• • Un-drained pneumothorax
• • Severe bronchospasm
• • Head injury with ICP \> 25mmHg
• • Severe arterial hypotension
• • Trache-oesophageal fistula
• • Significant haemoptysis
• • Facial fractures
• • Vomiting
• • Flail segment
• • Epistaxis within two weeks