Correlation of Microbiome and Metabonomics With IgA Nephropathy

Launched by GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL · Jan 12, 2022

Keywords

ClinConnect Summary

This clinical trial is studying a condition called IgA Nephropathy (IgAN), which is a type of kidney disease that is common in China. Researchers want to understand how the bacteria in our mouths and throats might be related to IgAN and how they can help with early diagnosis and treatment. They believe that certain changes in these bacteria could play a role in the development of IgAN, and they aim to create a model that uses this information alongside clinical indicators to improve patient care.

To participate in this trial, you need to be at least 16 years old and have been diagnosed with IgAN through a kidney biopsy. It's important that you haven't taken antibiotics, probiotics, or had significant changes in your diet or medications in the month before joining the study. Participants will contribute samples for testing and will help researchers gather important information about the relationship between bacteria and IgAN. This research could lead to better ways to detect and treat this kidney disease in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • (1) Pathological changes of IgAN were confirmed by renal biopsy (2) Age ≥16 years (3) IgA deposition caused by secondary factors such as non-purpura glomerulonephritis, liver cirrhosis, SLE, HIV infection and hepatitis B virus associated nephritis (4) No antibiotics and/or functional foods (probiotics and/or prebiotics) for at least one month prior to sampling (5) No hormone or immunosuppressant treatment in the six months prior to sampling (6) No significant changes in diet or medication for at least one month (7) No other immune or autoimmune diseases, such as systemic lupus erythematosus (8) Signed informed consent
• Exclusion Criteria:
• • 1. Type I or type II diabetes
• • 2. Pregnancy and menstrual period
• • 3. Mental illness and inability to assess follow-up
• • 4. Medically diagnosed intestinal diseases such as irritable bowel syndrome and inflammatory bowel disease
• • 5. Viral hepatitis or other infectious diseases
• • 6. One month before specimen collection, use laxatives including but not limited to polyethylene glycol electrolyte dispersant, enema and other laxatives