The Cognitive-Behavioral Dysfunctions and the Potential of Neuroplasticity in Brain Tumors Patients During Radiotherapy

Launched by THE GREATER POLAND CANCER CENTRE · Dec 30, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how different types of radiation therapy (RT) affect the cognitive (thinking) and physical functions of patients with brain tumors. The researchers want to understand the impact of specific RT techniques—like Intensity-Modulated Radiation Therapy (IMRT), Whole Brain Radiation Therapy (WBRT), and CyberKnife (SRS)—on patients’ brain health, especially in areas that help with memory and learning. They will also look at whether certain rehabilitation therapies, such as cognitive exercises or physical activity, can help improve these functions after treatment.

To participate in this study, patients must be between 18 and 70 years old and have specific types of brain tumors (groups III and IV, or metastatic tumors). They must also be in generally good health. Over the course of the trial, participants will be evaluated at different times: before their radiation therapy, immediately after, 3 months later, and again at 6 months. The evaluations will include tests on brain function, imaging scans, and blood tests to check for markers related to brain health and recovery. The findings from this study could help develop better guidelines for physical and cognitive activity for brain tumor patients undergoing radiation therapy.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • Patients with three different CNS groups of tumors: from III and IV brain tumor groups, and metastatic tumors enrolled to RT,
• • Age between 18-70 years,
• • good general health conditions (according to Eastern Cooperative Oncology Group (ECOG) 0-2),
• • obtaining informed consent for participation in the study.
• Exclusion criteria:
• • Patients with numerous tumors (above two),
• • psychological or psychiatric illnesses treated pharmacologically,
• • neurological disorders (e.g. MS, Parkinson's disease, meningitis, etc.),
• • significant clinical circulatory failure (above III NYHA).