Respiratory Dysbiosis in Preschool Children with Asthma: Predictive of a Severe Form

Launched by UNIVERSITY HOSPITAL, BREST · Dec 30, 2021

Keywords

ClinConnect Summary

This clinical trial is studying how changes in the bacteria in the lungs, known as respiratory dysbiosis, might affect the severity of asthma in preschool children. Researchers believe that some children under 3 years old may not respond well to standard asthma treatments, like inhaled corticosteroids, due to this imbalance of lung bacteria. By understanding these differences, the study aims to find better ways to manage asthma in young children.

To participate in this trial, children must be between 1 and 3 years old and have a diagnosis of asthma from a pediatrician. Parents will need to give their consent, and the family should be part of the social security system. The trial is currently recruiting participants, and children with certain health issues or recent treatments may not be eligible. If your child qualifies, they will be closely monitored and may contribute to important research that could help improve asthma care for young children in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age greater than 1 year and less than 3 years
• • Diagnosis of asthma by a pediatrician
• • Parental consent
• • Affiliation to the social security system
• Exclusion Criteria:
• • Chronic pathologies: congenital heart disease, immune deficiency, cystic fibrosis, bronchopulmonary dysplasia, encephalopathy, primary ciliary dyskinesia, laryngomalacia, digestive pathology requiring digestive surgery
• • Premature \< 34 SA
• • Recent antibiotic therapy (\< 7 days)
• • Treatment with oral corticosteroid therapy within the previous 10 days.
• • Patient whose parent(s) is (are) minor(s)