The Detrimental Course of Acute Intestinal Ischemia

Launched by MAASTRICHT UNIVERSITY · Jan 4, 2022

Keywords

ClinConnect Summary

INTRODUCTION AND RATIONALE Acute intestinal ischemia remains a common clinical emergency with short-term mortality up to 80% and is often highly underestimated. , , It is a life-threatening clinical condition of diminished blood flow towards the gut, resulting in decreased supply of oxygen and nutrients to the intestinal tissue. Prolonged periods of ischemia are associated with disruption of the intestinal wall that normally functions as an important barrier. , The intestinal wall is composed of different layers and has a multitude of functions, such as the absorption of nutrients as well a...

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Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18 years
• • All consecutive patients admitted to one of the participating medical centers emergency departments (ED) or at the intensive care unit (ICU) (see 4.1 Population Base) with clinical suspicion of acute intestinal ischemia, which is based on;
• • clinical manifestation;
• • physical examination by the physician;
• • laboratory measurements;
• • physician's consideration to perform computed tomography (CT)-scan
• Exclusion Criteria:
• A subject who meets any of the following criteria will be excluded from participation in this study:
• • Age ≤ 18 years In order to evaluate the performance of the panel of markers for the acute intestinal ischemia in clinical practice, the study population must resemble the clinical patient population as closely as possible