Anatomical and Functional Imaging Correlates of Chronic Pain in Cerebral Palsy

Launched by HUGO W. MOSER RESEARCH INSTITUTE AT KENNEDY KRIEGER, INC. · Jan 14, 2022

Keywords

ClinConnect Summary

This clinical trial is studying how chronic pain and sensory issues in individuals with cerebral palsy (CP) are connected to changes in the brain. Researchers will use MRI scans, which are special pictures of the brain, to look for patterns that show how the brain is affected in people with CP who experience pain. The goal is to better understand the relationship between brain changes and chronic pain, which can help improve treatment options for those affected.

To participate, individuals must be at least 8 years old and have a diagnosis of cerebral palsy. There are two groups in the study: one group will only answer surveys, while the other group will also undergo MRI scans. Participants will need to lie still in the MRI machine for about 1.5 hours. There are no specific health conditions that would exclude participants, but they should be able to understand the study and provide consent. This trial is currently recruiting and is open to people of all genders.

Gender

ALL

Eligibility criteria

• Participants with CP (Survey-only):
• Inclusion Criteria:
• • Individual 8+ years of age
• • Diagnosis of cerebral palsy
• Exclusion Criteria:
• • -None
• Neurotypical participants: (Survey-only):
• Inclusion Criteria:
• • Individual 8+ years of age
• • Adult subject able to indicate understanding and affirmative consent OR Adult/child subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents
• Exclusion Criteria:
• • -Clinically-significant neurologic or developmental diagnosis
• Participants with CP (Survey and MRI):
• Inclusion Criteria:
• • Individual 8+ years of age
• • Adult subject able to indicate understanding and affirmative consent OR Adult subject unable to indicate understanding and affirmative consent AND subject assents AND LAR consents
• • Diagnosis of cerebral palsy
• • Clinical imaging demonstrating isolated periventricular white matter injury
• • Clinical judgment that all neurologic symptoms are attributable to non-progressive periventricular white matter injury
• • Able to lie still in scanner for 1.5 hours in at most 2 sessions and be able to have MRI
• Exclusion Criteria:
• • -None
• Neurotypical participants (Survey and MRI):
• Inclusion Criteria:
• • Individual 8+ years of age
• • Adult subject able to indicate understanding and affirmative consent
• • Able to lie still in scanner for 1.5 hours and be able to have MRI
• Exclusion Criteria:
• • -Clinically-significant neurologic or developmental diagnosis