MS-ResearchBiomarkerS

Launched by CEDARS-SINAI MEDICAL CENTER · Jan 11, 2022

Keywords

ClinConnect Summary

The MS-ResearchBiomarkerS clinical trial is looking into how certain factors can predict whether someone with Multiple Sclerosis (MS) or related conditions will experience worsening disability. Researchers aim to combine information from eye exams, blood tests, and brain scans to see if they can better understand changes in patients' abilities over time. This study is currently recruiting participants aged 18 and older, including those diagnosed with different types of MS, neuromyelitis optica spectrum disorders, or even healthy volunteers.

If you decide to participate, you will undergo various assessments, including eye tests and possibly MRI scans of your brain and spinal cord. However, there are some criteria to keep in mind: you should be able to give informed consent and not have any conditions that would prevent you from having an MRI, like certain metal implants or being pregnant. This study aims to improve how we understand and treat MS and related disorders, ultimately helping both patients and healthcare providers.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Subjects who meet any one of the following diagnostic criteria:
• • Diagnosis of MS, CIS,or RIS based on the 2017 revised McDonald criteria.
• • Diagnosis of NMOSD based on the 2015 revised NMOSD consensus diagnostic criteria.
• • Diagnosis of myelin oligodendrocyte glycoprotein (MOG)-related encephalomyelitis, optic neuritis, or other associated disease.
• • Diagnosis of neurological disorders other than MSRD.
• • Healthy volunteer.
• • Age ≥18.
• • Able to give informed consent.
• Exclusion Criteria:
• • Patients will be excluded from the MRI portions of the study if they have a contraindication to MRI(metallic implantsor foreign bodies, claustrophobia, MRI-incompatible pacemakers, MRI- incompatible prosthetic heart valves).
• • Patients will be excluded from the MRI portions of the study if they are pregnant, but their demographic, clinical information,and disability measures may still be captured under the study.
• • Patients will be excluded from the visual assessment portions of the study if they have had any recent ocular surgery (within the past two months), refractive errors of greater than or equal to ±6 diopters or other eye diseases that may affect or confound OCT/OCTA measurements (ex., age-related macular degeneration, advanced geographic atrophy, diabetic retinopathy, glaucoma).