Histamine as a Molecular Transducer of Adaptation to Exercise

Launched by UNIVERSITY OF OREGON · Jan 11, 2022

Keywords

ClinConnect Summary

This clinical trial, titled "Histamine as a Molecular Transducer of Adaptation to Exercise," is exploring how histamine—a substance in the body—might help improve how our bodies adapt to exercise, particularly in people who experience low blood pressure after exercise, known as postexercise hypotension. The study is currently recruiting participants aged 18 to 40 years, regardless of gender, but there are certain health conditions and factors that could prevent someone from joining. For example, individuals with a history of heart disease, high blood pressure, or those who smoke or use certain medications may not be eligible.

If you qualify and decide to participate, you can expect to engage in activities designed to assess how histamine works in relation to exercise. The study aims to better understand the body's responses to physical activity and how we can help improve health outcomes for those affected by low blood pressure after exercising. It's important to note that participants should not have ongoing medical treatments or conditions that might interfere with the study, and non-English speakers cannot participate. Overall, this research could provide valuable insights into how we adapt to physical activity and maintain good health.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age 18 -40
• Exclusion Criteria:
• • Systolic ≥ 120
• • Diastolic ≥ 80
• • Body mass index (BMI) ˃ 28 kg/m2
• • Prior diagnosis of cardiovascular disease, diabetes, autonomic disorders, or asthma
• • Smoking or nicotine use
• • Ongoing medical therapy (other than birth control)
• • Ongoing use of over-the-counter or prescription antihistamines
• • Allergies or hypersensitivities to drugs, local anesthetics, skin disinfectants, adhesives, or latex
• • Pregnant, breastfeeding subjects, or planning to become pregnant in the next 12 months
• • Mobility restrictions that interfere with physical activity
• • High physical activity based on International Physical Activity Questionaire (IPAQ1)
• • Non-English speaking